González-Cubero, Elsa González-Fernández, María L Olivera, Elias R Villar-Suárez, Vega
Published in
The spine journal : official journal of the North American Spine Society
Mesenchymal stem cells (MSCs) secretome or conditioned medium (CM) is a complex cocktail of different molecules, some of which, particularly those contained in extracellular vesicles, already have proven therapeutic applications. CM may well represent promising therapy for discogenic pain and the intention of this work is to assess its therapeutic ...
Khan, Huma Verma, Yeshvandra Rana, S V S
Published in
Biological trace element research
Health effects elicited by combined environmental exposures to xenobiotics, in many instances, still remain unresolved. One of these examples is the combined toxicity of arsenic and fluoride. The present study was undertaken to delineate the role of inflammation and apoptosis in hepatocellular death caused by co-exposure to arsenic and fluoride in ...
Yu, Sheng Li, Wen Tang, Lingxue Fan, Xinxin Yao, Senbang Zhang, Xiuqing Bi, Ziran Cheng, Huaidong
Published in
Cancer letters
Depression is a common and recurrent mental illness with a complicated etiology, but the specific pathogenesis is not clear. Breast cancer increases susceptibility to depression, which leads to a poor prognosis. Rapid advances in the understanding of tumor immunology and neuroimmunology have provided new evidence for the pathogenesis of depression....
Wellberg, Elizabeth A. Corleto, Karen A. Checkley, L. Allyson Jindal, Sonali Johnson, Ginger Higgins, Janine A. Obeid, Sarina Anderson, Steven M. Thor, Ann D. Schedin, Pepper J.
...
Published in
Breast Cancer Research : BCR
Background Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for hormone-dependent tumors. Menopause is a time when significant weight gain occurs in many women, and clinical and preclinical studies have identified menopause (or ovariectomy) as a period of vul...
Lefeuvre, Caroline Roux, Marine Blanchard, Simon Le Guillou-Guillemette, Hélène Boursier, Jérôme Lunel-Fabiani, Françoise Jeannin, Pascale Pivert, Adeline Ducancelle, Alexandra
Published in
Scientific Reports
The A1762T/G1764A double mutant in the basal core promoter (BCP) region of the hepatitis B virus (HBV) is associated with severe hepatic lesions while the G1899A mutation with the double mutant is associated with a significant reduction in the risk of severe fibrosis. This study aims to measure a number of markers in the serum of patients with chro...
Jeon, Junseok Park, Jeeeun Boo, Hyo Jin Yang, Kyeong Eun Lee, Cheol-Jung Lee, Jung Eun Kim, Kyunga Kwon, Ghee Young Huh, Wooseong Kim, Dae Joong
...
Published in
Scientific Reports
Crescentic glomerulonephritis (CrGN) usually requires urgent immunosuppressive treatment. However, aggressive immunosuppressive treatment is often difficult because of the patients’ medical conditions or comorbidities. Prognostic markers including urinary cytokines/chemokines as noninvasive biomarkers were explored in CrGN patients. This prospectiv...
Wakiya, Risa Ueeda, Kiyo Nakashima, Shusaku Shimada, Hiromi Kameda, Tomohiro Mansour, Mai Mahmoud Fahmy Kato, Mikiya Miyagi, Taichi Sugihara, Koichi Mizusaki, Mao
...
Published in
Scientific Reports
We investigated the effect of hydroxychloroquine (HCQ) as an add-on treatment to immunosuppressants on the expression of proinflammatory cytokines in patients with systemic lupus erythematosus. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-6, IL-8, vascular endothelial growth factor (VEGF)-A, monocyte chemotactic protein-1 (...
Amin, Jay Erskine, Daniel Donaghy, Paul C Surendranathan, Ajenthan Swann, Peter Kunicki, Amy P Boche, Delphine Holmes, Clive McKeith, Ian G O'Brien, John T
...
Published in
Neurobiology of disease
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral inflammation in midlife increases the risk of late-onset AD, and data supporting inflammation being a...
Zhou, Xiaomei Zhang, Jun Lv, Wenchang Zhao, Chongru Xia, Yu Wu, Yiping Zhang, Qi
Published in
Journal of Experimental & Clinical Cancer Research : CR
Background Breast cancer is the leading female cancer type and the cause of cancer-related mortality worldwide. Adipocytes possess important functions of energy supply, metabolic regulation, and cytokine release, and are also the matrix cell that supports mammary gland tissue. In breast cancer tumor microenvironment (TME), adipocytes are the promin...
Areecheewakul, Sudartip Adamcakova-Dodd, Andrea Haque, Ezazul Jing, Xuefang Meyerholz, David K. O’Shaughnessy, Patrick T. Thorne, Peter S. Salem, Aliasger K.
Published in
Particle and Fibre Toxicology
Background It has been shown that copper oxide nanoparticles (CuO NPs) induce pulmonary toxicity after acute or sub-acute inhalation exposures. However, little is known about the biodistribution and elimination kinetics of inhaled CuO NPs from the respiratory tract. The purposes of this study were to observe the kinetics of pulmonary inflammation d...
