Abruzzo, P. M. Matté, A. Bolotta, A. Federti, E. Ghezzo, A. Guarnieri, T. Marini, M. Posar, A. Siciliano, A. De Franceschi, L.
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Published in
Journal of Translational Medicine
BackgroundIt has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and pro-oxidant soluble signature in non-syndromic ASD and age-matched typically developing (TD) control children.MethodsWe analyzed l...
Lee, Ellen E Sears, Dorothy D Liu, Jinyuan Jin, Hua Tu, Xin M Eyler, Lisa T Jeste, Dilip V
BACKGROUND:Persons with schizophrenia and schizoaffective disorder (PwS) have high rates of cardiometabolic pathology that contributes to premature mortality. Adiponectin is a metabolic hormone affecting insulin sensitivity and inflammation, and is active in the brain. High-molecular weight (HMW) adiponectin is considered a more sensitive marker of...
Magliozzi, R. Marastoni, D. Rossi, S. Castellaro, M. Mazziotti, V. Pitteri, M. Gajofatto, A. Monaco, S. Benedetti, M. D. Calabrese, M.
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Published in
BMC Neurology
BackgroundClinical and imaging follow-up coupled with cerebrospinal fluid (CSF) and possibly serum profiling could provide information on disease activity and disability evolution in multiple sclerosis patients.Case presentationWe describe the case of a relapsing-remitting MS patient whose history was characterized by failure of several therapeutic...
Burrack, Kristina S. Hart, Geoffrey T. Hamilton, Sara E.
Published in
Malaria Journal
Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial...
Llanos, Pedro J. Andrijauskaite, Kristina
Published in
Gravitational and Space Research
Research indicates that exposure to microgravity leads to immune system dysregulation. However, there is a lack of clear evidence on the specific reasons and precise mechanisms accounting for these immune system changes. Past studies investigating space travel-induced alterations in immunological parameters report many conflicting results, explaine...
Aziz, Najib Detels, Roger Quint, Joshua J. Gjertson, David Ryner, Timothy Butch, Anthony W.
Published in
BMC Immunology
BackgroundCytokines, chemokines, adipocytokines, soluble cell receptors, and immune activation markers play an important role in immune responsiveness and can provide prognostic value since they reflect underlying conditions and disease states. This study was undertaken to investigate the components of biological variation for various laboratory te...
dos Santos, Cesar Miguel Momesso Diniz, Vinicius Leonardo Sousa Bachi, André Luis Lacerda dos Santos de Oliveira, Laiane Cristina Ghazal, Tamara Passos, Maria Elizabeth Pereira de Oliveira, Heloisa Helena Murata, Gilson Masi, Laureane Nunes Martins, Amanda Roque
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Published in
Nutrition & Metabolism
BackgroundObesity can lead to a chronic systemic inflammatory state that increases the risk of cancer development. Therefore, this study aimed to evaluate the alterations in tumor non-infiltrated lymphocytes function and melanoma growth in animals maintained on a high-fat diet and/or moderate physical exercise program in a murine model of melanoma....
Afridi, Ruqayya Khan, Ashraf Ullah Khalid, Sidra Shal, Bushra Rasheed, Hina Ullah, Muhammad Zia Shehzad, Omer Kim, Yeong Shik Khan, Salman
Published in
BMC Pharmacology and Toxicology
BackgroundPoncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. The present study aimed to explore the anti-allodynic and anti-hyperalgesic potentials of poncirin in murine models of inflammatory pain.MethodsThe analgesic ...
Mazaki-Tovi, M. Bolin, S. R. Schenck, P. A.
Published in
BMC Veterinary Research
BackgroundObesity in cats has been associated with alterations in adipokines including: adiponectin, interleukin-6 (IL6), and tumor necrosis factor-α (TNFα). Omega-3 polyunsaturated fatty acids have multiple beneficial effects on obesity-associated disorders, and therefore may alleviate these alterations. This study aimed to determine the effects o...
Zeng, Jing Meng, Xinyu Zhou, Ping Yin, Zhihua Xie, Qinglian Zou, Hong Shen, Nan Ye, Zhizhong Tang, Yuanjia
Published in
Arthritis Research & Therapy
BackgroundNeuropsychiatric systemic lupus erythaematosus (NP-SLE) is one of the major manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely unknown. The abnormal activation of the type I IFN signalling pathway is involved in SLE pathogenesis and is linked to NP-SLE, but the effect of IFN-α on NP-SLE encephalopathy ha...
