Frugé, Andrew D Van der Pol, William Rogers, Laura Q Morrow, Casey D Tsuruta, Yuko Demark-Wahnefried, Wendy
Published in
Journal of the Academy of Nutrition and Dietetics
Akkermansia muciniphila (AM) is a gram-negative, mucin-degrading bacteria inhabiting the gastrointestinal tract associated with host phenotypes and disease states. Explore characteristics of overweight and obese female early-stage (0 to II) breast cancer patients with low AM relative abundance (LAM) vs high (HAM) enrolled in a presurgical weight-lo...
Qeadan, Fares Bansal, Pranshu Hanson, Joshua A. Beswick, Ellen J.
Published in
Journal of Translational Medicine
BackgroundGastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein kinase 2 (MK2) pathway is a regulator of inflammatory cytokine production that we have been studying in gastrointestinal cancers. Her...
Yang, Yanhua Pan, Qi Zou, Kaijie Wang, Haixing Zhang, Xiaoting Yang, Zhengmeng Lee, Wayne Yuk Wai Wei, Bo Gu, Weidong Yang, Yunzhi Peter
...
Published in
Stem Cell Research & Therapy
BackgroundDistraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to accelerate bone formation in DO. However, the optimal time point for cell therapy in DO remains unknown. This study sought to dete...
Rádiková, Žofia Penesová, Adela Vlček, Miroslav Havranová, Andrea Siváková, Monika Šiarnik, Pavel Žitňanová, Ingrid Imrich, Richard Turčáni, Peter Kollár, Branislav
...
Published in
Lipids in Health and Disease
BackgroundInflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be limited in chronic inflammatory diseases such as multiple sclerosis (MS). The aim of this study was ...
Dhanda, Ashwin D Yates, Euan Schewitz-Bowers, Lauren P Lait, Philippa J Lee, Richard W J Cramp, Matthew E
Published in
Gut and liver
Alcoholic hepatitis (AH) is an acute inflammatory liver condition with high early mortality rate. Steroids improve short-term survival but nonresponders have the worst outcomes. There is a clinical need to identify these high-risk individuals at the time of presentation. T cells are implicated in AH and steroid responsiveness. We measured ;ex vivo ...
Fischer, Jessica Hans, Didier Lamy, Olivier Marques-Vidal, Pedro Vollenweider, Peter Aubry-Rozier, Bérengère
Published in
Immunity & Ageing
Background“Inflammaging” is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level inflammation, with which deleterious effects on bone no longer need to be demonstrated, it is unclear whether inflammaging exerts de...
Lee, Sheng-Yu Wang, Tzu-Yun Chen, Shiou-Lan Chang, Yun-Hsuan Chen, Po-See Huang, San-Yuan Tzeng, Nian-Sheng Wang, Liang-Jen Lee, I-Hui Chen, Kao-Ching
...
Published in
International Journal of Bipolar Disorders
BackgroundThe aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma brain-derived neurotrophic factor (BDNF), cytokine levels, and metabolic profiles in patients with bipolar spectrum disorder.Method...
Samtiya, Mrinal Bhat, Mohd Iqbal Gupta, Taruna Kapila, Suman Kapila, Rajeev
Published in
Probiotics and antimicrobial proteins
Safety assessment of probiotic Lactobacillus fermentum MTCC-5898 (LF) with three doses (107, 109, and 1011 cfu/day/animal) was carried on Swiss albino mouse weanlings for 28 days using oral route. Health status of animals was monitored by physical assessment of body weight, organ indices, and histological appearances of liver and intestine along wi...
Luo, Meng Hu, MiaoMiao Feng, Xu XiaoLi, Wu Dong, DeGang Wang, WanChun
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Lactobacillus is one of the bacteria strains which has been widely used in human life, has valuable probiotic properties. In the present study, L. reuteri FLRE5K1 was isolated from healthy mouse kidney and tested for its anti-melanoma activity in cell assays and animal models. The results showed that L. reuteri FLRE5K1 could significantly reduce th...
Wang, Rui Wang, Wei Xu, Jingjing Liu, Dexiang Wu, Huiran Qin, Xiaqing Jiang, Hong Pan, Fang
Published in
Experimental neurology
Adverse childhood experience is a major risk factor for the onset of depression in adulthood. Neuroinflammation characterized by microglial activation and cytokine secretion is involved in susceptibility to depression induced by early life stress. Jumonji domain-containing protein 3 (Jmjd3), a trimethylated lysine 27 in histone 3 (H3K27me3) demethy...
