Fisse, Anna Lena May, Caroline Motte, Jeremias Pedreiturria, Xiomara Breuer, Thomas G K Schneider-Gold, Christiane Marcus, Katrin Gold, Ralf Yoon, Min-Suk Pitarokoili, Kalliopi
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Published in
Neurocritical care
Diagnosis of intensive care unit acquired weakness (ICUAW) is challenging. Pathogenesis of underlying critical illness polyneuromyopathy (CIPNM) remains incompletely understood. This exploratory study investigated whether longitudinal neuromuscular ultrasound examinations and cytokine analyses in correlation to classical clinical and electrophysiol...
Koo, Ja Wook Wohleb, Eric S
Published in
Biological psychiatry
Chronic stress causes physiological and hormonal adaptations that lead to neurobiological consequences and behavioral and cognitive impairments. In particular, chronic stress has been shown to drive reduced neurogenesis and altered synaptic plasticity in brain regions that regulate mood and motivation. The neurobiological and behavioral effects of ...
Yeung, Chris Ho Ching Schooling, C Mary
Published in
International journal of epidemiology
Systemic inflammation has been suggested to be associated with Alzheimer's-disease progression, although whether it is a cause or a downstream effect is still controversial. This study aims to assess the effect of systemic inflammatory regulators on Alzheimer's disease within a bidirectional Mendelian-randomization design. Genetic associations with...
Bullenkamp, Jessica Mengoni, Veronica Kaur, Satdip Chhetri, Ismita Dimou, Paraskevi Astroulakis, Zoë M J Kaski, Juan Carlos Dumitriu, Ingrid E
Published in
Cardiovascular research
Inflammation has important roles in atherosclerosis. CD4+CD28null (CD28null) T cells are a specialized T lymphocyte subset that produce inflammatory cytokines and cytotoxic molecules. CD28null T cells expand preferentially in patients with acute coronary syndrome (ACS) rather than stable angina and are barely detectable in healthy subjects. Importa...
Chugh, Rishi Man Park, Hang-soo El Andaloussi, Abdeljabar Elsharoud, Amro Esfandyari, Sahar Ulin, Mara Bakir, Lale Aboalsoud, Alshimaa Ali, Mohamed Ashour, Dalia
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Published in
Stem Cell Research & Therapy
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow mesenchymal stem cells (BM-hMSC) and their secreted factors (secretome) exhibit robust anti-inflammator...
Flores-Aguilar, Lisi Iulita, M. Florencia Orciani, Chiara Tanna, Neil Yang, Jingyun Bennett, David A. Cuello, A. Claudio
Published in
Journal of Neuroinflammation
BackgroundBrain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid deposition is associated with neuroinflammation and cognitive deficits, we studied brain inflammatory cytokine expression and cognitiv...
Leenen, S Hermens, M de Vos van Steenwijk, P J Bekkers, R L M van Esch, E M G
Published in
Cancer immunology, immunotherapy : CII
Endometriosis is a risk factor for low-grade serous, clear cell, and endometroid ovarian carcinoma. In both endometriosis and ovarian carcinoma, immunological factors are associated with clinical outcome. Chronic inflammation in endometriosis may be linked to tumorigenesis, but exact processes contributing to endometriosis-associated ovarian carcin...
Mallmann, Auriana Serra Vasconcelos Chaves, Raquell de Castro de Oliveira, Natália Ferreira Oliveira, Iris Cristina Maia Capibaribe, Victor Celso Cavalcanti Valentim, José Tiago da Silva, Daniel Moreira Alves Sartori, Danusio Pinheiro Rodrigues, Gabriel Carvalho Filho, Adriano José Maia Chaves
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Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Stress is crucially related to the pathophysiology of mood disorders, including depression. Since the effectiveness and number of the current pharmacological options still presents significant limitations, research on new substances is paramount. In rodents, several findings have indicated that corticosterone administration induces the manifestatio...
Fathimath Muneesa, M Shaikh, Sadiya B Jeena, T M Bhandary, Yashodhar P
Published in
International immunopharmacology
Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease (ILD) that is marked by scarring of lung tissue, ultimately leading to respiratory failure. The survival rate of IPF is disappointing and to date demonstrates a clinical quandary. The exact etiology of the disease remains under discussion. According to the recent hypothesis,...
Xian, Hongxu Liu, Yuan Rundberg Nilsson, Alexandra Gatchalian, Raphaella Crother, Timothy R Tourtellotte, Warren G Zhang, Yi Aleman-Muench, German R Lewis, Gavin Chen, Weixuan
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Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exe...
