Publication search
with Cyclophilin A as keyword

Extracellular cyclophilin A induces cardiac hypertrophy via the ERK/p47phox pathway.

Published in Molecular and cellular endocrinology

Excessive reactive oxygen species (ROS) are a critical driver of cardiac hypertrophy developing into heart failure. Cyclophilin A (CyPA), a member of the cyclophilin family, has been highlighted as a main secreted ROS-induced factor. The mechanism by which extracellular CyPA interacts with cardiomyocytes is unclear. We showed that extracellular CyP...

Fibroblast-enhanced cyclophilin A releasing from U937 cell upregulates MMP-2 in gingival fibroblast.

Published in Journal of periodontal research

This in vitro study aimed to evaluate the expression of cyclophilin A (CyPA) in U937 monocytic cells after coculturing with the human gingival fibroblasts (HGFs) and the effect of CyPA on the augmentation of MMP-2 expression in the coculture environment. Leukocyte infiltration in gingival connective tissue is one of the major findings in the lesion...

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Vascular contributions to dementia and Alzheimer's disease are increasingly recognized1-6. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical stages of Alzheimer's disease5,8-10. The E4 variant of apolipoprotein E (APOE4), the main suscept...

Gracilin-Derivatives as Lead Compounds for Anti-inflammatory Effects.

Published in Cellular and molecular neurobiology

Gracilins are diterpenes derivative, isolated from the marine sponge Spongionella gracilis. Natural gracilins and synthetic derivatives have shown antioxidant, immunosuppressive, and neuroprotective capacities related to the affinity for cyclophilins. The aim of this work was to study anti-inflammatory and immunosuppressive pathways modulated by gr...

Cyclophilin A and matrix metalloproteinase-9: Their relationship, association with, and diagnostic relevance in stable c...

Published in Vascular

Rho-associated protein kinase and cyclophilin a are involved in inorganic phosphate-induced calcification signaling in v...

Published in Journal of pharmacological sciences

Arterial calcification, a risk factor of cardiovascular events, develops with differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Cyclophilin A (CypA) is a peptidyl-prolyl isomerase involved in cardiovascular diseases such as atherosclerosis and aortic aneurysms, and rho-associated protein kinase (ROCK) is involved i...

A cyclophilin A (CypA) from Apostichopus japonicus modulates NF-κB translocation as a cofactor.

Published in Fish & shellfish immunology

As a ubiquitously expressed protein, cyclophilin A (CypA) is involved in a variety of pathological process, including immune suppression, inflammation, cell apoptosis, viral infection and stress response. However, the functional roles of CypA were largely unknown in economic marine animals. In this report, a novel CypA gene from sea cucumber Aposti...