Cao, Mengfei Mao, Ziqi Peng, Meiling Zhao, Qianru Sun, Xia Yan, Jinchuan Yuan, Wei
Published in
Molecular and cellular endocrinology
Excessive reactive oxygen species (ROS) are a critical driver of cardiac hypertrophy developing into heart failure. Cyclophilin A (CyPA), a member of the cyclophilin family, has been highlighted as a main secreted ROS-induced factor. The mechanism by which extracellular CyPA interacts with cardiomyocytes is unclear. We showed that extracellular CyP...
Kuo, Po-Jan Lin, Chi-Yu Chen, Tzu-Ying Hung, Tsung-Fu Lin, Hsiao-Lun Chiu, Hsien-Chung Chiang, Cheng-Yang Lin, Fu-Gong Fu, Earl
Published in
Journal of periodontal research
This in vitro study aimed to evaluate the expression of cyclophilin A (CyPA) in U937 monocytic cells after coculturing with the human gingival fibroblasts (HGFs) and the effect of CyPA on the augmentation of MMP-2 expression in the coculture environment. Leukocyte infiltration in gingival connective tissue is one of the major findings in the lesion...
Kim, Kyusik
The abundant cellular protein Cyclophilin A (CypA) was found to bind to HIV-1 capsid (CA) in 1993. Since that time, several complementary methods, including disruption of the binding interface by cyclosporine A, CA mutants, and CypA mutants, have been used to demonstrate that CypA acts within human target cells to promote HIV-1 infection. In contra...
Su, Zizhuo Lin, Maohuan Zhang, Haijun Li, Jiajie Wu, Meiping Lv, Hanlu Wang, Jingfeng Xie, Shuanglun
Published in
Journal of Vascular Research
Introduction: The exocytosis of cyclophilin A (CyPA) by a vesicular pathway in response to reactive oxygen species has been determined. However, other sources of extracellular CyPA remain obscure. Objective: The aim of this study was to determine the role of autophagy in the secretion of CyPA. Methods and Results: Rapamycin induced the activation o...
Montagne, Axel Nation, Daniel A Sagare, Abhay P Barisano, Giuseppe Sweeney, Melanie D Chakhoyan, Ararat Pachicano, Maricarmen Joe, Elizabeth Nelson, Amy R D'Orazio, Lina M
...
Vascular contributions to dementia and Alzheimer's disease are increasingly recognized1-6. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical stages of Alzheimer's disease5,8-10. The E4 variant of apolipoprotein E (APOE4), the main suscept...
Gegunde, Sandra Alfonso, Amparo Alonso, Eva Alvariño, Rebeca Botana, Luis M
Published in
Cellular and molecular neurobiology
Gracilins are diterpenes derivative, isolated from the marine sponge Spongionella gracilis. Natural gracilins and synthetic derivatives have shown antioxidant, immunosuppressive, and neuroprotective capacities related to the affinity for cyclophilins. The aim of this work was to study anti-inflammatory and immunosuppressive pathways modulated by gr...
Ebrahim, Hala F Abdel Hamid, Fatma F Haykal, Mohamed A Soliman, Ahmed F
Published in
Vascular
Tsuda, Tatsuya Imanishi, Masaki Oogoshi, Mizuho Goda, Mitsuhiro Kihira, Yoshitaka Horinouchi, Yuya Zamami, Yoshito Ishizawa, Keisuke Ikeda, Yasumasa Hashimoto, Ichiro
...
Published in
Journal of pharmacological sciences
Arterial calcification, a risk factor of cardiovascular events, develops with differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Cyclophilin A (CypA) is a peptidyl-prolyl isomerase involved in cardiovascular diseases such as atherosclerosis and aortic aneurysms, and rho-associated protein kinase (ROCK) is involved i...
Liu, Jiqing Guo, Ming Lv, Zhimeng Wang, Zhenhui Shao, Yina Li, Chenghua
Published in
Fish & shellfish immunology
As a ubiquitously expressed protein, cyclophilin A (CypA) is involved in a variety of pathological process, including immune suppression, inflammation, cell apoptosis, viral infection and stress response. However, the functional roles of CypA were largely unknown in economic marine animals. In this report, a novel CypA gene from sea cucumber Aposti...
Zheng, Zhi-Wan Li, Jiao Chen, Han He, Jin-Lei Chen, Qi-Wei Zhang, Jian-Hui Zhou, Qi Chen, Da-Li Chen, Jian-Ping
Published in
Parasites & Vectors
BackgroundNew therapeutic drugs are urgently needed against visceral leishmaniasis because current drugs, such as pentavalent antimonials and miltefosine, produce severe side effects and development of resistance. Whether cyclosporine A (CsA) and its derivatives can be used as therapeutic drugs for visceral leishmaniasis has been controversial for ...