Parkhi, Mayur Chatterjee, Debajyoti Kashyap, Dharambir Aggarwal, Ashish Radotra, Bishan
Published in
Neuropathology : official journal of the Japanese Society of Neuropathology
Rosai-Dorfman disease (RDD) is characterized by clonal proliferation of S-100 positive histiocytes and variable emperipolesis. It commonly affects cervical lymph nodes. Central nervous system (CNS) involvement is extremely rare. We attempted to evaluate the Cyclin D1 expression and frequency of KRAS and BRAF mutations in the RDD involving the CNS. ...
Liu, Liu Jiang, Qiqi Du, Chong Yang, Tongtong Zhou, Liuhua Chen, Jiawen Gu, Lingfeng Wang, Qiming Wang, Zemu Wang, Hao
...
Published in
European journal of pharmacology
Restoration of the expression of factors regulating neonatal heart regeneration in the adult heart can promote myocardial repair. Therefore, investigations of the regulatory factors that play key roles in neonatal heart regeneration are urgently needed for the development of cardiac regenerative therapies. In our previous study, we identified ankyr...
Kuzmanov, Aleksandar Salemi, Souzan Eberli, Daniel Kranzbühler, Benedikt
Published in
Neoplasia (New York, N.Y.)
PSMA expression gradually increases from benign prostatic hyperplasia to adenocarcinoma of the prostate and is therefore used for the development of improved diagnostic (PSMA)-based prostate cancer imaging tools. Pharmacological induction of PSMA is therefore eminent to further improve the detection rate of PSMA-based imaging. Our previous studies ...
Boulay, Gaylor Broye, Liliane Dong, Rui Iyer, Sowmya Sanalkumar, Rajendran Xing, Yu-Hang Buisson, Rémi Rengarajan, Shruthi Naigles, Beverly Duc, Benoît
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EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator...
Chen, Jing Wei, Jin-Qiu Hong, Mo-Na Zhang, Zhong Zhou, Han-Dan Lu, Yuan-Yuan Zhang, Jia Guo, Yue-Tong Chen, Xin Wang, Ji-Guang
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Published in
Cardiovascular drugs and therapy
Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. Dysfunction of adventitial fibroblast has emerged as a critical regulator in vascular remodeling, while the potential mechanism remains unclear. In this study, we sought to determine the effect of different activation of MAPKs in...
Moreau, Manon Dard, Rodolphe Madani, Amélia Kandiah, Janany Kassis, Nadim Ziga, Jessica Castiglione, Héloïse Day, Solenn Bourgeois, Thomas Matrot, Boris
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Down syndrome (DS) is a genetic disease characterized by a supernumerary chromosome 21. Intellectual deficiency (ID) is one of the most prominent features of DS. Central nervous system defects lead to learning disabilities, motor and language delays, and memory impairments. At present, a prenatal treatment for the ID in DS is lacking. Subcutaneous ...
Sutanto, Renaldo Neahring, Lila Marques, Andrea Serra Jacobo, Mauricio Jacobo Kilinc, Seda Goga, Andrei Dumont, Sophie
The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function, particularly in the mechanical context of solid tumors, remains poorly understood. Here, we constitutiv...
Pizzi, Marco Bongiovanni, Lucia Lorenzi, Luisa Righi, Simona Scarmozzino, Federico Balzarini, Piera Santoro, Luisa Mussolin, Lara Carraro, Elisa Pillon, Marta
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Published in
Virchows Archiv : an international journal of pathology
Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) is a rare lymphoid neoplasm, usually occurring in the pediatric/young-adult age. Despite this, subsets of cases occur in elderly patients and express CD5, possibly entering the differential diagnosis with adult aggressive lymphomas, such as blastoid/pleomorphic mantle cell lymphoma (MCL-B/P)...
Pedraza, Neus Monserrat, Ma Ventura Ferrezuelo, Francisco Torres-Rosell, Jordi Colomina, Neus Miguez-Cabello, Federico Párraga, Javier Picañol Soto, David López-Merino, Esperanza García-Vilela, Celia
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Published in
Cellular and molecular life sciences : CMLS
Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the onset of differentiation in neuronal precursors. However, cytoplasmic functions and targets of Ccnd1 in post-mitotic neurons are unknown. Here we identify the α4 subunit of gamma-aminobutyric acid (GABA)...
John, Reena Rachel Sam, Nisha Chandrasekaran, Balamanikandasrinivasan
Published in
Journal of maxillofacial and oral surgery
Oral cancer ranks sixth place worldwide among other cancers and is known for its high morbidity and mortality rates. Among oral cancer, oral squamous cell carcinomas (OSCC) remains the most common. Expression of specific biomarkers are known to be related to the prognosis of the OSCC. An immunohistochemistry study was performed to evaluate the expr...
