Gawish, Riem Maier, Barbara Obermayer, Georg Watzenboeck, Martin L Gorki, Anna-Dorothea Quattrone, Federica Farhat, Asma Lakovits, Karin Hladik, Anastasiya Korosec, Ana
...
Published in
eLife
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options to prevent sepsis-associated immunopathology remain scarce. Here, we established a mouse model of long-lasting disease tolerance during severe sepsis, manifested by diminished immunothrombosi...
Miharada, Natsumi Rydström, Anna Rak, Justyna Larsson, Jonas
Published in
Stem cell reports
Hematopoietic stem cells (HSCs) are typically characterized by transplantation into irradiated hosts in a highly perturbed microenvironment. Here, we show that selective and temporally controlled depletion of resident HSCs through genetic deletion of Gata2 constitutes efficient recipient conditioning for transplantation without irradiation. Strikin...
Aalto, Anne Olguin-Olguin, Adan Raz, Erez
Published in
Frontiers in Cell and Developmental Biology
Similar to many other organisms, zebrafish primordial germ cells (PGCs) are specified at a location distinct from that of gonadal somatic cells. Guided by chemotactic cues, PGCs migrate through embryonic tissues toward the region where the gonad develops. In this process, PGCs employ a bleb-driven amoeboid migration mode, characterized by low adhes...
Pagella, Pierfrancesco Nombela-Arrieta, César Mitsiadis, Thimios A.
Published in
International Journal of Molecular Sciences
Specific stem cell populations within dental mesenchymal tissues guarantee tooth homeostasis and regeneration throughout life. The decision between renewal and differentiation of stem cells is greatly influenced by interactions with stromal cells and extracellular matrix molecules that form the tissue specific stem cell niches. The Cxcl12 chemokine...
Azar, Mohammad Reza Mohammad Hoseini Hamed Aghazadeh Mohammed, Halgurd Nadhim Sara, Mehdi Rezai Seghin Hosseini, Arezoo Shomali, Navid Tamjidifar, Rozita Tarzi, Saeed Mansouri, Mahmoud Sarand, Sahar Pashaei
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Published in
International Immunopharmacology
Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. The role of microRNAs (miRNAs/miRs) as small (19–25 nucleotides in length) non-coding RNA molecules that modify gene expression has been shown in several types of cancer. 5-Fluorouracil (5-FU) and oxaliplatin (Ox) are two common chemotherapeutic agents used...
Azar, Mohammad Reza Mohammad Hoseini Aghazadeh, Hamed Mohammed, Halgurd Nadhim Sara, Mehdi Rezai Seghin Hosseini, Arezoo Shomali, Navid Tamjidifar, Rozita Tarzi, Saeed Mansouri, Mahmoud Sarand, Sahar Pashaei
...
Published in
International Immunopharmacology
Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. The role of microRNAs (miRNAs/miRs) as small (19–25 nucleotides in length) non-coding RNA molecules that modify gene expression has been shown in several types of cancer. 5-Fluorouracil (5-FU) and oxaliplatin (Ox) are two common chemotherapeutic agents used...
Makitani, Kouki Ogo, Naohisa Asai, Akira
Published in
Physiological reports
Kidney fibrosis is a histological hallmark of chronic kidney disease (CKD) and is believed to be involved in the progression of CKD. Therefore, inhibition of kidney fibrosis is a potential strategy for slowing CKD progression. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by interleukin-6 and...
Vétillard, Mathias
Comprendre par quels mécanismes les cellules dendritiques (DC) régulent l’immunité est essentiel. Les DC résident dans les tissus périphériques et notamment la peau. Au sein de leur tissu de résidence, les DC immatures alternent des phases de migration non orientée avec des phases de capture des antigènes (AG). Dans ce contexte, la migration est en...
Chisolm, Danielle A Cheng, Wayne Colburn, Shelby A Silva-Sanchez, Aaron Meza-Perez, Selene Randall, Troy D Weinmann, Amy S
Published in
Immunity
Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic variation in the widely used B6...
Tampakakis, Emmanouil Miyamoto, Matthew Kwon, Chulan
Published in
Journal of visualized experiments : JoVE
Pluripotent stem cells offer great potential for understanding heart development and disease and for regenerative medicine. While recent advances in developmental cardiology have led to generating cardiac cells from pluripotent stem cells, it is unclear if the two cardiac fields - the first and second heart fields (FHF and SHF) - are induced in plu...
