Zhou, Yuru Kong, Yunyuan Jiang, Mei Kuang, Linju Wan, Jinhua Liu, Shuyuan Zhang, Qian Yu, Kuai Li, Na Le, Aiping
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Published in
Cancer biology & therapy
Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary. In this study, we demonstrated that curcumin induced the expression of AIM2, IFI16, and NLRC4 inflammasomes in leukemia cel...
Kurra, Pallavi Narra, Kishore Orfali, Raha Puttugunta, Srinivasa Babu Khan, Shah Alam Meenakshi, Dhanalekshmi Unnikrishnan Francis, Arul Prakash Asdaq, Syed Mohammed Basheeruddin Imran, Mohd.
Published in
Frontiers in Pharmacology
The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of a curcumin (CMN)-loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions ...
Patel, Ashish Rajendran, Malathi Shah, Ashish Patel, Harnisha Pakala, Suresh B Karyala, Prashanthi
Published in
Journal of biomolecular structure & dynamics
COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China. The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell. Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting en...
Askari, Gholamreza Sahebkar, Amirhossein Soleimani, Davood Mahdavi, Atena Rafiee, Sahar Majeed, Muhammed Khorvash, Farzin Iraj, Bijan Elyasi, Mahshid Rouhani, Mohammad Hossein
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Published in
Trials
Background COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a positive effect on the control of COVID-19 complications. This study aimed to a...
Ibarra-Martínez, David Muñoz-Ortega, Martin Humberto Quintanar-Stephano, Andrés Martínez-Hernández, Sandra Luz Ávila-Blanco, Manuel Enrique Ventura-Juárez, Javier
Published in
Veterinary research communications
Secretions of beneficial intestinal bacteria can inhibit the growth and biofilm formation of a wide range of microorganisms. Curcumin has shown broad spectrum antioxidant, anti-inflammatory, and antimicrobial potential. It is important to evaluate the influence of these secretions with bioactive peptides, in combination with curcumin, to limit grow...
Garbuio, Matheus Dias, Lucas D de Souza, Larissa M Corrêa, Thaila Q Mezzacappo, Natasha F Blanco, Kate C de Oliveira, Kleber T Inada, Natalia M Bagnato, Vanderlei S
Published in
Photodiagnosis and photodynamic therapy
Dengue, Zika, chikungunya, and yellow fever are arboviruses transmitted by Aedes aegypti mosquito. In this regard, a number of techniques have emerged aiming to combat its proliferation. Elimination of Aedes aegypti larvae by photodynamic action has been reported as an efficient approach. In this regard, this study was aimed at synthetize and chara...
Guéguinou, Maxime Ibrahim, Sajida Bourgeais, Jérôme Robert, Alison Pathak, Trayambak Zhang, Xuexin Crottès, David Dupuy, Jacques Ternant, David Monbet, Valérie
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Background and aims: Recent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To overcome treatment resistance, we aimed to evaluate the role of the mitochondrial sodium-calcium-lithium exchanger (NCLX) and its targeting in CRC. We also identified curcumin as a new inhibitor of NCLX.Me...
Khanna, Aman Das S, Syam Kannan, R Swick, Andrew G Matthewman, Cristina Maliakel, Balu Ittiyavirah, Sibi P Krishnakumar, I M
Published in
Nutritional neuroscience
A novel highly bioavailable curcumin-galactomannan (CGM) formulation was shown to have improved blood-brain-barrier (BBB) permeability of free curcuminoids in animal models; however, this has not been established in humans. The present study was conducted to determine the functional effects of CGM on brain waves in healthy individuals, owing to its...
Ayadilord, Malaksima Saharkhiz, Mansoore Naseri, Mohsen Emadian Razavi, Fariba
Published in
Molecular biology reports
Human Dental pulp derived-mesenchymal stem cells (hDP-MSCs) have the capability of selfrenewal, multipotency, as well as immunosuppressive properties. They are ideal candidates for regenerating damaged dental tissue and treating inflammation-related diseases. However, methods (such as genetic variation) to improve the immunomodulatory and regenerat...
Darmian, Mahsa Ahmadi Hoseini, Rastegar Amiri, Ehsan Golshani, Sanam
Published in
Journal of diabetes and metabolic disorders
Aerobic training (AT) and Turmeric Supplementation (TS) are known to exert multiple beneficial effects including metabolic status and Oxidative Stress. To our knowledge, data on the effects of AT and TS on metabolic status and oxidative stress biomarkers related to inflammation in subjects with Hyperlipidemic Type 2 Diabetes Mellitus (HT2DM) are sc...
