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Hattori, Tatsuya Nakashima, Kenta Marutani, Takayuki Kiso, Yoshiaki Nishi, Yoshisuke Mukai, Hidehito
Published in
Biochemical and biophysical research communications
Mitocryptide-1 (MCT-1) is a novel neutrophil-activating peptide derived from mitochondrial cytochrome c oxidase subunit VIII, and its physiological role and involvement in various diseases have not yet been elucidated. Generating neutralizing antibodies against the function of MCT-1 is of particular importance for investigating its physiological an...
Sciani, Juliana Mozer Sampaio, Marlos Cortez Zychar, Bianca Cestari Gonçalves, Luis Roberto de Camargo Giorgi, Renata Nogueira, Thiago de Oliveira de Melo, Robson Lopes Teixeira, Catarina de Fátima Pereira Pimenta, Daniel Carvalho
Published in
Peptides
Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there have been reports of inflammatory ...
Seki, Tetsuo Fukamizu, Akiyoshi Kiso, Yoshiaki Mukai, Hidehito
Published in
Biochemical and Biophysical Research Communications
Peptides simultaneously produced during maturation and degradation of peptidergic hormones and functional proteins have recently become a great interest because they display unpredictably different biological roles than the parent proteins. Namely, we discovered two novel functional cryptic peptides, mitocryptide-1 (MCT-1) and mitocryptide-2 (MCT-2...
Mukai, Hidehito Kikuchi, Miharu Fukuhara, Shigetomo Kiso, Yoshiaki Munekata, Eisuke
Published in
Biochemical and Biophysical Research Communications
Amphiphilic peptides with positive charges such as substance P (SP) and mastoparan (MP) are known to induce exocytosis in rat peritoneal mast cells. To elucidate whether and how intracellular Ca 2+ signaling is involved in the peptide-induced exocytosis, here we investigated the relationships between an increase in intracellular free Ca 2+ concentr...
