Published in International Journal of Surgery Case Reports
• Cinnamon is a coumarin that can cause coagulopathy when used in excess. • Dietary coumarin is a recognized cause of postoperative haemorrhage. • Reactive haemorrhage can cause significant morbidity. • Coagulopathy due to dietary coumarin can be rectified with fresh frozen plasma. • A thorough dietary history is imperative in safe patient care.
Published in Molecular diversity
Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins were rationally designed and synthesized. Preliminary bioassay showed that compounds 7c, 7h and 7l exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50 μg/mL, 7c exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of ...
Published in Journal of Natural Medicines
Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E ( 1 – 5 ) and two new coumarins, caloforines F and G ( 6 and 7 ). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combina...
Published in European journal of medicinal chemistry
This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glyc...
Development of new drugs with broad-spectrum to combat RNA viruses would be beneficial to mankind but faces a great challenge. We designed and efficiently synthesized a series of quinazolin-4-amine-SCH2-coumarin conjugated compounds. Our data of the virus-cell-based assay show five new conjugates inhibit chikungunya virus with EC50 values as potent...
Published in Archives of Microbiology
One approach to overcome the antimicrobial resistance of many pathogens is to associate compounds with antimicrobial properties and obtain combinations superior compared to the effect of each compound. To identify a possible potentiating effect, we tested and analyzed the inhibitory effect of the combination of coumarin with two pyrazole derivative...
Published in Discover Food
Scopoletin is a phytochemical of coumarins distributed in some plants. The aim of this study was the evaluation of scopoletin content and antioxidant activity of nettle, mallow, purslane, knot-grass, dill and coriander encountered in Black Sea regions. Analyses were conducted on the leaves and stems of these plants, except knot-grass. The lowest sc...
Published in IOP Conference Series: Earth and Environmental Science
The stingless honey bee (Trigona sp) has various types, one of which is Heterotrigona itama. Currently, in East Kalimantan, especially in Samarinda, many kelulut honey is meliponiculture, namely in North Samarinda Sub district in Tanah Merah village, Lubuk sawah village and Gunung Lingai village. Are there differences in the chemical components, po...
Published in Food chemistry
Herein, using Fe3O4 nanoparticles (Fe3O4 NPs) as a magnetic artificial peroxidase, an "on-off" ratiometric photoluminescence sensor with high-sensitivity and high-selectivity for coumarin was constructed based on photoinduced electron transfer (PET) between 7-hydroxycoumarin and rhodamine B (RB). The results showed that Fe3O4 NPs catalyzed H2O2 to ...
Published in Survey of ophthalmology
Diabetic retinopathy (DR) is one of the leading causes of blindness in the world. DR represents the most common microvascular complication of diabetes, and its incidence is constantly rising. The complex interactions between inflammation, oxidative stress, and the production of free oxygen radicals caused by prolonged exposure to hyperglycemia dete...
