Published in BMC Research Notes
Objective Neuroscience research using laboratory animals has increased over the years for a number of reasons. Some of these studies require the use of anesthetics for surgical procedures. However, the use of anesthetics promotes several physiological changes that may interfere with experimental results. Although the anesthetics and methods of deli...
Conditions experienced during early development can lead to profound long-lasting changes in physiology and behaviour.The extent to which such “programming” effects are transmitted to the next generation remains largely unexplored. Here, weassessed whether maternal exposure to elevated corticosterone stress hormone during early post-natal developme...
Published in Psychopharmacology
Guanosine has been shown to potentiate ketamine's antidepressant-like actions, although its ability to augment the anxiolytic effect of ketamine remains to be determined. This study investigated the anxiolytic-like effects of a single administration with low doses of ketamine and/or guanosine in mice subjected to chronic administration of corticost...
Published in Psychopharmacology
Rationale Mephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factors that could contribute to the increased vulnerability to mephedrone abuse is still poorly understoo...
Published in European Journal of Wildlife Research
Urbanization constitutes one of the major transformations of natural habitats, creating new areas characterized by multiple potential wildlife stressors. Birds that live in highly anthropized zones are confronted with physiological and behavioural challenges caused by these stressors. Here, we investigated if several health parameters differed betw...
Published in Heliyon
phosphoprotein signaling; diisopropyl fluorophosphate; chlorpyrifos oxon; corticosterone; Gulf War Illness; mitogen activated protein kinase
Published in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Stress is crucially related to the pathophysiology of mood disorders, including depression. Since the effectiveness and number of the current pharmacological options still presents significant limitations, research on new substances is paramount. In rodents, several findings have indicated that corticosterone administration induces the manifestatio...
Published in Molecular neurobiology
Collapsin response mediator protein 5 (CRMP5), a member of the CRMP family, is expressed in the brain, particularly in the hippocampus, an area of the brain that can modulate stress responses. Social stress has a well-known detrimental effect on health and can lead to depression, but not all individuals are equally sensitive to stress. To date, res...
Published in The British journal of nutrition
We previously reported that dietary vitamin E deficiency increased anxiety-like behaviour in rats exposed to social isolation. Here, we performed a detailed investigation of this phenomenon and its underlying mechanism. First, we fed Wistar rats with a vitamin E-free diet for 3 d, 1 week or 2 weeks and found an increase in anxiety-like behaviour af...
Published in Progress in neuro-psychopharmacology & biological psychiatry
Reduction in direct social contact with peers during early adolescence is thought to be a risk factor for an increase in depressive symptoms, but there is still no clear evidence to suggest early behavioral manifestations and their association with the later outcome of social distancing during this period. To address this question, we used social i...
