Eker, Candan Basdas, Rumeysa Balci, Burcin Karamustafaoglu Bastu, Ercan Gunel, Tuba
Published in
Journal of gynecology obstetrics and human reproduction
Aim of this study was to define the relationship between RIF (Recurrent Implantation Failure) and endometrial mtDNA copy number. A total of 50 women of reproductive age including twenty-five patients clinically diagnosed with RIF and twenty-five fertile women as healthy controls were recruited into the study. Endometrial biopsy samples were obtaine...
Ansbro, Megan R. Jacob, Christopher G. Amato, Roberto Kekre, Mihir Amaratunga, Chanaki Sreng, Sokunthea Suon, Seila Miotto, Olivo Fairhurst, Rick M. Wellems, Thomas E.
...
Published in
Malaria Journal
BackgroundLong regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple locations across Southeast Asia. Genetic studies have identified sin...
Ashby, Cody Rutherford, Michael Bauer, Michael A. Peterson, Erich A. Wang, Yan Boyle, Eileen M. Wardell, Christopher P. Walker, Brian A.
Published in
BMC Bioinformatics
BackgroundThe study of cancer genomics continually matures as the number of patient samples sequenced increases. As more data is generated, oncogenic drivers for specific cancer types are discovered along with their associated risks. This in turn leads to potential treatment strategies that pave the way to precision medicine. However, significant f...
Brown, Jacqueline Stepien, Andrzej J. Willem, Pascale
Published in
BMC Cancer
BackgroundEsophageal squamous cell carcinoma (ESCC) is an aggressive cancer with one of the highest world incidences in the Eastern Cape region of South Africa. Several genome wide studies have been performed on ESCC cohorts from Asian countries, North America, Malawi and other parts of the world but none have been conducted on ESCC tumors from Sou...
Zhang, Yuchen Zhang, Hanwen Qu, Zhan Zhang, Xiujie Cui, Jinjie Wang, Canhua Yang, Litao
Published in
Food chemistry
Molecular characterization of exogenous DNA integrations in host genome is a key aspect in risk assessment of bioengineered crops. However, gaining a clear understanding of the molecular characters of a bioengineered crop using conventional techniques remains a challenging task. Herein, we report the full molecular characterization of one new trans...
Grimm, Oliver Kranz, Thorsten M. Reif, Andreas
Published in
Current Psychiatry Reports
Purpose of ReviewAttention deficit hyperactivity disorder (ADHD) shows high heritability in formal genetic studies. In our review article, we provide an overview on common and rare genetic risk variants for ADHD and their link to clinical practice.Recent findingsThe formal heritability of ADHD is about 80% and therefore higher than most other psych...
Sangtani, Ajleeta Wang, Chen Weaver, Amy Hoppman, Nicole L Kerr, Sarah E Abyzov, Alexej Shridhar, Viji Staub, Julie Kocher, Jean-Pierre A Voss, Jesse S
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Published in
Gynecologic oncology
We aimed to assess whether endometrial cancer (EC) can be detected in shed DNA collected with vaginal tampon by analyzing copy number, methylation markers, and mutations. Tampons were collected prior to hysterectomy from 38 EC patients and 28 women with benign indications. Extracted tampon DNA underwent the following: 1) low-coverage whole genome s...
Mohan, Sumitra Foy, Victoria Ayub, Mahmood Leong, Hui Sun Schofield, Pieta Sahoo, Sudhakar Descamps, Tine Kilerci, Bedirhan Smith, Nigel K Carter, Mathew
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Published in
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Small cell lung cancer (SCLC) accounts for ∼250,000 deaths worldwide each year. Acquisition of adequate tumour biopsies is challenging and liquid biopsies present an alternative option for patient stratification and response monitoring. We applied whole genome next-generation sequencing (NGS) to circulating-free DNA (cfDNA) from 39 patients with li...
Kesäniemi, Jenni Lavrinienko, Anton Tukalenko, Eugene Moutinho, Ana Mappes, Tapio Møller, Anders Mousseau, Timothy Watts, Phillip
Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank voles (Myodes glareolus) were collected from the chernobyl exclusion zone (CEZ), where animals are exposed to elevated levels of ra...
Klæstad, Elise Opdahl, Signe Engstrøm, Monica Jernberg Ytterhus, Borgny Wik, Elisabeth Bofin, Anna Mary Valla, Marit
Published in
Breast Cancer Research and Treatment
Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy number change and molecular subtype, proliferation and prognosis, and between MRPS23 gene expression and molecular subtype and p...
