Yenduri, Gowtham Costa, Antonio P Xu, Xiaoming Burgess, Diane J
Published in
International journal of pharmaceutics
Liposomes were one of the earliest drug delivery vehicles used for anti-cancer therapeutics and similarly, lipid-based nanoparticles have been used for abundance of applications as gene therapies. The methods to produce these particles have remained relatively unchanged until the recent emergence of continuous manufacturing. Continuous processing e...
Jaspers, Maarten Kulkarni, Sri Sharath Tegel, Florian Roelofs, Timo P. de Wit, Myrthe T.W. Janssen, Pauline H.M. Meir, Bernhard Weinekötter, Ralf Dickhoff, Bastiaan H.J.
Published in
International Journal of Pharmaceutics: X
• Continuous mixing improves blend uniformity of pharmaceutical powder mixtures. • Blend uniformity is highly dependent on excipient properties in a batch process. • Continuous mixing is more robust, with little impact of material properties. • Powder bulk density strongly affects blend homogeneity in a batch process. • Blending of low API dosages ...
Silva-Brenes, Diana V. Emmanuel, Noémie López Mejías, Vilmalí Duconge, Jorge Vlaar, Cornelis Stelzer, Torsten Monbaliu, Jean-Christophe
peer reviewed / Intensified production of smart drug modafinil under continuous flow and sustainable conditions.
Bekaert, Bram Grymonpré, W. Novikova, A. Vervaet, Chris Vanhoorne, Valérie
In this study, quantitative relationships were established between blend properties, process settings and blending responses via multivariate data-analysis. Four divergent binary blends were composed in three different ratios and processed at various throughputs and impeller speeds. Additionally, different impeller configurations were tested to see...
Rao, Rajat Radhakrishna Pandey, Abhijeet Hegde, Aswathi R. Kulkarni, Vijay Induvadan Chincholi, Chetan Rao, Vinay Bhushan, Indu Mutalik, Srinivas
Published in
AAPS PharmSciTech
In order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought through for its fundamental advantages over conventional batch manufacturing. CM eliminates the key gaps through the...
Panikar, Savitha Li, Jingzhe Rane, Varsha Gillam, Sean Callegari, Gerardo Kurtyka, Bogdan Lee, Sau Muzzio, Fernando
Published in
International journal of pharmaceutics
In a pharmaceutical manufacturing process, Critical Quality Attributes (CQAs) need to be monitored not only for the final product but also for intermediates. Blend uniformity of powders is one such attribute that needs to be measured to ensure the quality of the final product. Multiple in-line sensors were implemented within a Direct Compaction (DC...
Svane, Rasmus Pedersen, Troels Hirschberg, Cosima Rantanen, Jukka
Published in
Journal of pharmaceutical sciences
Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulatio...
Hu, Chuntian
Published in
Journal of Flow Chemistry
Pharmaceutical production remains one of the last industries that predominantly uses batch processes, which are inefficient and can cause drug shortages due to the long lead times or quality defects. Consequently, pharmaceutical companies are transitioning away from outdated batch lines, in large part motivated by the many advantages of continuous ...
Bandari, Suresh Nyavanandi, Dinesh Dumpa, Nagireddy Repka, Michael A
Published in
Advanced drug delivery reviews
Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufact...
Ryckaert, A Stauffer, F Funke, A Djuric, D Vanhoorne, V Vervaet, C De Beer, T
Published in
International journal of pharmaceutics
The potential of torque as in-process control (IPC) to monitor granule size in twin-screw wet granulation (TSG) was investigated. An experimental set-up allowing the collection of granules at four different locations (i.e., in the wetting zone, after the first and second kneading zone and at the end of the granulator) of the granulator screws was u...
