LI, Ruisha Wan, Qian-Hong
Published in
Chromatographia
AbstractIn this paper, a thioether-embedded mixed-mode cyano-bonded chromatographic packing has been prepared by using gas silylation method and thiol-ene click chemistry. The solid-state 13C CP/MAS NMR and elemental analysis have been used to characterize the synthesized materials. Detailed chromatographic characterization of the new phase was per...
Kurgachev, D. A. Kotelnikov, O. A. Novikov, D. V. Kusherbaeva, V. R. Gorbin, S. I. Tomilova, E. V. Zhaksynbaeva, A. Dementeva, N. B. Malkov, V. S. Bakibaev, A. A.
...
Published in
Chromatographia
AbstractMono-, di-, and tetramethylglycolurils were synthesized, isolated, and purified. For the first time, the cis- and the trans-isomers of N,N-dimethylglycoluril were isolated as individual substances by semi-preparative HPLC method. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, and HR–HPLC–MS. The EI mass spect...
Xia, Yong Liu, Zhihao Huang, Yong Huang, Xiaojun Liao, Mengya Zhang, Yiwen Ma, Xuelei
Published in
Journal of the Iranian Chemical Society
A sensitive and accurate LC method for the determination of AT13148 enantiomeric purity has been developed and validated. Baseline separation with a resolution higher than 1.8 was accomplished within 15 min using a Chiralpak AD-H column (250 × 4.6 mm; particle size 5 μm) and n-hexane: 2-propanol: diethylamine (85:15:0.1, v/v) as mobile phase at a f...
Riccardi, Carmela Buiarelli, Francesca Di Filippo, Patrizia Distratis, Sisto Giannetti, Luigi Manganelli, Maura Neri, Bruno Pomata, Donatella Stefanelli, Mara
Published in
Chromatographia
AbstractA quick and reproducible screening analytical method for the simultaneous determination of algal toxins, belonging to different chemical classes, was developed to provide a toxin profile in seawater, useful to assess potential risks to environment and human health. The target compounds were: gonyautoxin-1,4, gonyautoxin-2,3, decarbamoylgony...
Devarakonda, Venkata SubbaRao Merecek, James
Published in
Chromatographia
A novel liquid chromatographic method for the analysis of four potential impurities in the anti-cancer agent Bexarotene has been developed and validated using efficient chromatographic separation, achieved on a C18 column (50 mm × 2.1 mm, 1.7-μm particles) with a simple isocratic mobile phase at a flow rate of 0.5 mL min−1. The mobile phase consist...
Li, Jiali Huo, Zhixia Chen, Lei Wan, Qian-Hong
Published in
Chromatographia
AbstractMercaptopropyl functionalized polymethylsilsesquioxane microspheres have been prepared by a two-step acid/base catalyzed hydrolysis and co-condensation of methyltrimethoxysilane (MTMS) and mercaptopropyltrimethoxysilane (MpTMS) precursors. The mercaptopropyl loading of the microspheres is controlled by regulating the ratio of MpTMS to MTMS ...
Ye, Tinghong Liao, Mengya Hu, Mingxing Xie, Yongmei Zhang, Yiwen
Published in
Chromatographia
A sensitive and accurate LC method was developed and further validated for the determination of enantiomeric purity of GSK962040. Before separation, a pre-column derivatization procedure was performed. Baseline separation with a resolution higher than 1.9 was accomplished within 15 min using a Chiralpak AD-H (250 × 4.6 mm; particle size 5 μm) colum...
Fang, Aiping Zhang, Yue Shen, Jiang Sun, Shijin Zou, Junyi Yao, Yuqin
Published in
Journal of the Iranian Chemical Society
A sensitive and accurate liquid chromatographic method for the determination of AR-42 enantiomeric purity has been developed and validated. Baseline separation with a resolution higher than 1.9 was accomplished within 10 min using a CHIRALPAK AD column (250 mm × 4.6 mm; particle size 5 μm) and n-hexane/2-propanol/diethylamine (75:25:0.1 v/v/v) as m...
Li, Xiaomin Chen, Zhengping Liu, Chunyi Tang, Jie Xue, Danlu Cao, Lihua Xu, Dong
Published in
Chromatographia
A precise and sensitive HPLC method was developed for the determination of p-toluenesulfonoxypropyl-(+)-dihydrotetrabenazine [TsOP-(+)-DTBZ] enantiomeric purity. The effects of mobile phase composition and column temperature on the enantioresolution and analysis time of the enantiomers were investigated. The optimized chiral separation method was p...
Rahim, Nurul Yani Tay, Kheng Soo Mohamad, Sharifah
Published in
Chromatographia
In this study, β-cyclodextrin functionalized ionic liquid was prepared by adding 1-benzylimidazole onto 6-monotosyl-6-deoxy-β-cyclodextrin (β-CDOTs) to obtain β-CD-BIMOTs. β-CD-BIMOTs were then bonded onto the modified silica to produce chiral stationary phases (β-CD-BIMOTs-CSP). The performance of β-CD-BIMOTs-CSP was evaluated by observing the ena...
