Appel, Tobias Manuel Stein, Claudia Brandt, Christian Rödel, Jürgen Frietsch, Jochen J Miethke, Jenny Hochhaus, Andreas Hilgendorf, Inken
Published in
Infection
Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility tes...
Baliga, Pallavi Goolappa, Puneeth Thadooru Shekar, Malathi Kallappa, Girisha Shivani
Published in
Probiotics and antimicrobial proteins
Multidrug-resistant bacteria are emerging as a major global threat to public health. Bacteriophages are an important source of antimicrobial enzymes and could be developed as an alternative antibiotic candidate. This study investigates the antibacterial capacity of the endolysin LysE against Aeromonas hydrophila. The endolysin LysE gene was cloned ...
Coz, Elsa Jouy, Eric Cazeau, Géraldine Jarrige, Nathalie Chauvin, Claire Delignette-Muller, Marie-Laure
Colistin resistance has been the subject of much attention since mcr genes encoding plasmid-mediated colistin resistance description in 2015. To date, surveillance data about resistance levels encountered in food-producing animals are scarce. In France, the Resapath dataset, consisting in a large collection of disk diffusion antibiogram results tra...
Landa, Guillermo Alejo, Teresa Sauzet, Theo Laroche, Julian Sebastian, Victor Tewes, Frederic Arruebo, Manuel
Compared to parenteral administration of colistin, its direct pulmonary administration can maximize lung drug deposition while reducing systemic adverse side effects and derived nephrotoxicity. Current pulmonary administration of colistin is carried out by the aerosolization of a prodrug, colistin methanesulfonate (CMS), which must be hydrolized to...
Yasugi, Mayo Hatoya, Shingo Motooka, Daisuke Kondo, Daisuke Akiyoshi, Hideo Horie, Masayuki Nakamura, Shota Shimada, Terumasa
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Veterinary microbiology
The emergence of mcr plasmid-mediated colistin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among companion dogs and cats poses a risk of the animals acting as reservoirs for cross-species transmission. However, current knowledge of mcr-harboring ESBL-producing Enterobacterales in companion dogs and cats is still limite...
Öz Gergin, Özlem Gergin, İsmail Şamil Pehlivan, Sibel Seckin Cengiz Mat, Ozge Turan, Işıl Tuğçe Bayram, Adnan Gönen, Zeynep Burçin Korkmaz, Şeyda Bıcer, Cihangir Yildiz, Karamehmet
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Published in
Toxicology mechanisms and methods
Colistin is an effective antibiotic against multidrug-resistant gram-negative bacterial infections; however, neurotoxic effects are fundamental dose-limiting factors for this treatment. Stem cell therapy is a promising method for treating neuronal diseases. Multipotent mesenchymal stromal cells (MSC) represent a promising source for regenerative me...
Rhouma, Mohamed Madec, Jean-Yves Laxminarayan, Ramanan
International audience
Dalmasso, Guillaume Beyrouthy, Racha Brugiroux, Sandrine Ruppé, Etienne Guillouard, Laurent Bonnin, Virginie Saint-Sardos, Pierre Ghozlane, Amine Gaumet, Vincent Barnich, Nicolas
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BackgroundThe plasmid-mediated resistance gene mcr-1 confers colistin resistance in Escherichia coli and paves the way for the evolution to pan-drug resistance. We investigated the impact of mcr-1 in gut colonization in the absence of antibiotics using isogenic E. coli strains transformed with a plasmid encoding or devoid of mcr-1.ResultsIn gnotobi...
Thaotumpitak, Varangkana Sripradite, Jarukorn Atwill, Edward R Jeamsripong, Saharuetai
BackgroundTilapia is a primary aquaculture fish in Thailand, but little is known about the occurrence of antimicrobial resistance (AMR) in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae colonizing healthy tilapia intended for human consumption and the co-occurrence of these AMR bacteria in the cultivation water.MethodsThis study determi...
Formenti, Nicoletta Guarneri, Flavia Bertasio, Cristina Parisio, Giovanni Romeo, Claudia Scali, Federico Birbes, Laura Boniotti, Maria Beatrice Diegoli, Giuseppe Candela, Loredana
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Antimicrobial resistance and infection control
Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. Although the isolates were phenotypically susceptible to colistin, the emerge...
