Siedner, Mark J Moorhouse, Michelle A Simmons, Bryony de Oliveira, Tulio Lessells, Richard Giandhari, Jennifer Kemp, Stephen A Chimukangara, Benjamin Akpomiemie, Godspower Serenata, Celicia M
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Abstract
Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load P P = 0.002) and for those on DTG-based treatm...
Ribas, Antoni Algazi, Alain Ascierto, Paolo A Butler, Marcus O Chandra, Sunandana Gordon, Michael Hernandez-Aya, Leonel Lawrence, Donald Lutzky, Jose Miller, Wilson H
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Combining PD-L1 blockade with inhibition of oncogenic mitogen-activated protein kinase (MAPK) signaling may result in long-lasting responses in patients with advanced melanoma. This phase 1, open-label, dose-escalation and -expansion study (NCT02027961) investigated safety, tolerability and preliminary efficacy of durvalumab (anti-PD-L1) combined w...
Pimentel, Gabriela Sales Ceccato, Maria das Graças Braga Costa, Juliana de Oliveira Mendes, Jullye Campos Bonolo, Palmira de Fátima Silveira, Micheline Rosa
Published in
Revista de Saúde Pública
OBJECTIVE To assess longitudinally the change in quality of life in people living with HIV initiating antiretroviral therapy in three public reference services specialized in HIV care in Belo Horizonte, Brazil. METHODS Prospective cohort study among people living with HIV, aged 18 years or older, and initiating antiretroviral therapy. We obtained s...
Ávila, Natally Gonçalves de Carneiro, Juliana Umbelino Alves, Fernanda Donner Corrêa, Izabele Vian da Silveira Vallandro, Juliana Paludo
Abstract Background Malnutrition can affect the clinical course of hospitalized patients, increasing hospital stay, infections, mortality, and hospital costs. Among heart disease patients, the malnutrition prevalence ranges from 25 to 51.9%. Objective To assess the prevalence of malnutrition and its association with clinical complications in cardia...
Gupta, Anil; von Heymann, Christian; Magnuson, Anders; Alahuhta, Seppo; Fernando, Roshan; Van de Velde, Marc; 34202; Mercier, Frederic J; Schyns-van den Berg, Alexandra MJ;
BACKGROUND: Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache (PDPH). We aimed to describe management practices and outcomes after PDPH treated by epidural blood patch (EBP) or no EBP. METHODS: Following ethics committee approval, patients who developed PDPH after accidental dural ...
Fisher, Lawrence Polonsky, William Asuni, Adijat Jolly, Yasmin Hessler, Danielle
AimsTo describe the effects of the COVID-19 pandemic on adults with T1D or T2D in the U.S.MethodsParticipants, recruited from the Taking Control of Your Diabetes Research Registry, were ≥19 years old and diagnosed with either T1D or T2D for ≥12 months. Participants completed an online survey on a HIPAA-protected platform.ResultsCompleted surveys we...
Smith, Alicia K Ratanatharathorn, Andrew Maihofer, Adam X Naviaux, Robert K Aiello, Allison E Amstadter, Ananda B Ashley-Koch, Allison E Baker, Dewleen G Beckham, Jean C Boks, Marco P
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Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl...
Cohen, Isaac V Makunts, Tigran Moumedjian, Talar Issa, Masara A Abagyan, Ruben
Chloroquine (CQ) and hydroxychloroquine (HCQ) are on the World Health Organization's List of Essential Medications for treating non-resistant malaria, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, both drugs are currently used off-label in hospitals worldwide and in numerous clinical trials for the treatment of SARS...
Monteagudo-Sánchez, Ana Hernandez Mora, Jose Ramon Simon, Carlos Burton, Adam Tenorio, Jair Lapunzina, Pablo Clark, Stephen Esteller, Manel Kelsey, Gavin López-Siguero, Juan Pedro
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Fantozzi, Paolo J Pampena, Emanuele Di Vanna, Domenico Pellegrino, Eugenia Corbi, Daniele Mammucari, Stefano Alessi, Federica Pampena, Riccardo Bertazzoni, Giuliano Minisola, Salvatore
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BackgroundThe novel Coronavirus Disease-19 (COVID-19) continues to have profound effect on global health. Our aim was to evaluate the prevalence and characterize specific symptoms associated with COVID-19.MethodsThis retrospective study included 326 patients with confirmed SARS-CoV-2 infection evaluated at the Emergency Department of the Umberto I ...