Knowles, Liam G Armanious, Abanoub J Peng, Youyi Welsh, William J James, Morgan H
Published in
Addiction neuroscience
Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high prevalence and substantial morbidity and mortality rates, treatment options for these disorders remain limited. O...
Wagner, Karla D Fiuty, Phillip Page, Kimberly Tracy, Erin C Nocera, Maryalice Miller, Colin W Tarhuni, Lina J Dasgupta, Nabarun
Published in
Drug and alcohol dependence
Overdose deaths involving stimulants and opioids simultaneously have raised the specter of widespread contamination of the stimulant supply with fentanyl. We quantified prevalence of fentanyl in street methamphetamine and cocaine, stratified by crystalline texture, analyzing samples sent voluntarily to a public mail-in drug checking service (May 20...
Salinas, Armando Lee, Jeong Augustin, Shana Zhang, Shiliang Patriarchi, Tommaso Morales, Marisela Mateo, Yolanda Lovinger, David Tian, Lin
The development of genetically encoded dopamine sensors such as dLight has provided a new approach to measuring slow and fast dopamine dynamics both in brain slices and in vivo, possibly enabling dopamine measurements in areas like the dorsolateral striatum (DLS) where previously such recordings with fast-scan cyclic voltammetry (FSCV) were difficu...
Kwon, Jaehan Kim, Hyun Jin Lee, Hyoung-Ro Ho, Won-Kyung Kim, Joung-Hun Lee, Suk-Ho
Published in
Biological psychiatry
Unbalanced activity of medium spiny neurons (MSNs) of the direct and indirect pathways mediates reward-related behaviors induced by addictive drugs. Prelimbic (PL) input to MSNs in the nucleus accumbens core (NAcC) plays a key role in cocaine-induced early locomotor sensitization (LS). However, the adaptive plastic changes at PL-to-NAcC synapses un...
Singh, Seema Thangaraj, Annadurai Chivero, Ernest T Guo, Ming-Lei Periyasamy, Palsamy Buch, Shilpa
Published in
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Despite the ability of combination antiretroviral therapy (cART) to suppress viremia, there is persistence low levels of HIV proteins such as Transactivator of transcription (Tat) in the central nervous system (CNS), contributing to glial activation and neuroinflammation. Accumulating evidence also implicates the role of drugs of abuse in exacerbat...
Roque-Torres, José Ramírez-Martínez, Laura Ramos-Meléndez, Ediel O García-Rodríguez, Omar Rodríguez-López, Agustín Guerrios, Lourdes Rodríguez-Ortiz, Pablo
Published in
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Substance misuse has long been recognized as a major predisposing risk factor for traumatic injury. However, there still exists no clear scientific consensus regarding the impact of drug use on patient outcomes. Therefore, this study aims to evaluate the demographic profile, hospital-course factors, and outcomes of trauma patients based on their to...
Bach, Paxton Ti, Lianping Hayashi, Kanna Cui, Zishan Milloy, M-J Fairbairn, Nadia
Published in
Journal of substance use and addiction treatment
Unregulated stimulant use is rising globally, though trends in use of cocaine and crystal methamphetamine (CM), the two most commonly used unregulated stimulants in North America, are poorly characterized in many settings. In this study we examined patterns and associations between the injection of cocaine and CM over time in an urban Canadian sett...
Jakob, Dominik Andreas Lewis, Meghan Benjamin, Elizabeth Robinson Haltmeier, Tobias Schnüriger, Beat Exadaktylos, Aristomenis Konstantinos Demetriades, Demetrios
Published in
European journal of trauma and emergency surgery : official publication of the European Trauma Society
The aim of this study was to assess the impact of pre-injury stimulant use (amphetamine, cocaine, methamphetamine and/or ecstasy) on outcomes after isolated severe traumatic brain injury (TBI). Retrospective 2017 TQIP study, including adult trauma patients (≥16 years old) who underwent drug and alcohol screening on admission and sustained an isolat...
Jones, A A Schneider, K E Tobin, K E O'Sullivan, D Latkin, C A
Published in
Journal of substance use and addiction treatment
Opioids and stimulants are increasingly implicated in overdose deaths, particularly among minoritized groups. We examined daily opioid and cocaine co-use, nonfatal overdoses, and naloxone carrying among minoritized people who inject drugs (PWID). The study derived data from 499 PWID in Baltimore City, MD, recruited using street-based outreach betwe...
Le, Aaron L. Lynch, Wendy J. Rissman, Emilie F.
Published in
Neuroendocrinology
Introduction: Women are more vulnerable to cocaine’s reinforcing effects and have a more rapid course to addiction after initial cocaine use as compared to men. Studies in rodents similarly indicate an enhanced sensitivity to the reinforcing effects of cocaine in females versus males. Levels of estradiol (E2) are correlated with vulnerability to th...