Barbosa-Méndez, Susana Pérez-Sánchez, Gilberto Becerril-Villanueva, Enrique Salazar-Juárez, Alberto
Published in
Journal of psychiatric research
Melatonin is a hormone that produces behavioral, pharmacological, and physiological effects through the activation of MT1 and MT2 melatonin receptors. Melatonin receptors participate in the modulation of the reinforcing effects of cocaine. Some studies report that dosing of melatonin decreases cocaine-induced locomotor activity and cocaine self-adm...
Tiet, Quyen Q Moos, Rudolf H
Published in
Addictive behaviors
Stimulant misuse, overdose, and related deaths have increased dramatically. Identifying and referring individuals with stimulant use disorder to treatment may reduce misuse and overdose. This study validated the 2-item Screen of Drug Use (SoDU; Tiet et al., 2015) to screen for stimulant use disorder (and for cocaine and amphetamine use disorders) i...
Cai, Wen Ting Han, Joonyeup Kim, Wha Young Kim, Jeong-Hoon
Published in
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are differentially regulated in the nucleus accumbens (NAcc) of the brain after cocaine exposure. However, these results are supported only by biochemical and electrophysiological methods, but have not been validated with immunohistochemistry. To overcome the restriction of anti...
Bender, Brooke N Torregrossa, Mary M
Published in
Neuropharmacology
Cue exposure therapy (CET) reduces craving induced by drug-associated cues in individuals with substance use disorders. A preclinical model of CET, cue extinction, similarly reduces cue-induced cocaine seeking in rodent self-administration models; however, those models may not capture the habitual or compulsive aspects of drug use. Thus, the effect...
Maldjian, Catherine
Published in
Radiology Case Reports
Mucoceles are benign lesions originating in the paranasal sinuses. Presented here is a novel case of a giant frontoethmoidal mucocele extending into the orbit and causing proptosis. The etiology was chronic transnasal cocaine abuse leading to extensive scarring and distortion of the nasal anatomy.
Hámor, Peter U Gobin, Christina M Schwendt, Marek
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Cocaine use disorder (CUD) is associated with neurobehavioral deficits that are resistant to current treatments. While craving and high rates of relapse are prominent features of CUD, persistent cognitive impairments are common and linked to poorer treatment outcomes. Here we sought to develop an animal model to study post-cocaine changes in drug s...
Gresnigt, Femke M.J. Gubbels, Nanda P. Riezebos, Robert K.
Published in
Toxicology Reports
Introduction Cocaine is considered a cardiovascular risk factor, yet it is not included in the frequently used risk stratification scores. Moreover, many guidelines provide limited advice on how to diagnose and treat cocaine-associated chest pain (CACP). This study aimed to determine the current practice for CACP patients in emergency departments a...
Pavarin, Raimondo Maria Sanchini, Samantha Tadonio, Leonardo Domenicali, Marco Caputo, Fabio Pacetti, Monica
Published in
Psychiatry research
Cohort study. This follow-up study (from 1975 to 2016) was aimed to estimate the mortality risk for suicide in a cohort of patients presenting to a public treatment centre for addiction (SERD) with Alcohol Use Disorder (AUD), Heroin Use Disorder - HUD or Cocaine Use Disorder (CUD), also relating to their access to a Mental Heath Service. Crude Mort...
Antonelli, Mariangela Fattore, Liana Sestito, Luisa Di Giuda, Daniela Diana, Marco Addolorato, Giovanni
Published in
Addictive behaviors
Substance Use Disorder (SUD) is a chronic and relapsing disease characterized by craving, loss of control, tolerance and physical dependence. At present, the combination of pharmacotherapy and psychosocial intervention is the most effective management strategy in preventing relapse to reduce dropout rates and promote abstinence in SUD patients. How...
Cathala, Adeline Devroye, Céline Robert, Éléa Vallée, Monique Revest, Jean-Michel Artigas, Francesc Spampinato, Umberto
Published in
Neuropharmacology
Serotonin2B receptor (5-HT2BR) antagonists inhibit cocaine-induced hyperlocomotion independently of changes of accumbal dopamine (DA) release. Given the tight relationship between accumbal DA activity and locomotion, and the inhibitory role of medial prefrontal cortex (mPFC) DA on subcortical DA neurotransmission and DA-dependent behaviors, it has ...
