Alammari, Khadijah M. Thabit, Abrar K.
Published in
Gut Pathogens
Background Clostridioides difficile infection (CDI) is a common hospital-associated diarrhea. Several antibiotics commonly associate with CDI; however, limited data are available on the duration of exposure prior to CDI. Moreover, studies on the characteristics of CDI patients in Saudi Arabia are limited. Therefore, this study aimed to characterize...
Tsuchiya, Ana Claudia Gomes, Erika Santos Kuaye, Arnaldo Yoshiteru Kabuki, Dirce Yorika
Published in
Food science and technology international = Ciencia y tecnologia de los alimentos internacional
The aims of this study were to evaluate the occurrence of Clostridium difficile in commercial raw meat and meat products commercialized in Brazil, and to determine the pathogenic potential and antimicrobial susceptibility of the isolates. After selective enrichment, the isolation of C. difficile involved plating with and without an alcohol shock tr...
Littmann, Eric R. Lee, Jung-Jin Denny, Joshua E. Alam, Zahidul Maslanka, Jeffrey R. Zarin, Isma Matsuda, Rina Carter, Rebecca A. Susac, Bože Saffern, Miriam S.
...
Published in
Nature Communications
Transfer of a host’s microbiota by faecal microbiota transplantation has shown benefit in the context of recurrent Clostridioides difficle infection. Here the authors shows the inflammatory status of the recipient can impact on engraftment and the efficacy of the introduced microbiota in a model of C.difficile infection.
Gupta, Annu Wash, Christopher Wu, Yingxing Sorrentino, Dario Nguyen, Vu Q
Published in
Digestive diseases and sciences
Inflammatory bowel disease (IBD) patients are at increased risk of developing Clostridioides difficile infection (CDI). Common methods to diagnose CDI involve a combination of tests including the toxin A/B enzyme immunoassay (Toxin) and toxin gene polymerase chain reaction assay (PCR). Disease outcomes in Toxin+ versus Toxin-PCR+ IBD patients remai...
Kulecka, Maria Waker, Edyta Ambrozkiewicz, Filip Paziewska, Agnieszka Skubisz, Karolina Cybula, Patrycja Targoński, Łukasz Mikula, Michał Walewski, Jan Ostrowski, Jerzy
...
Published in
BMC Microbiology
BackgroundClostridium difficile (C. difficile) is a major source of healthcare-associated infection with a high risk of recurrence, attributable to many factors such as usage of antibiotics, older age and immunocompromised status of the patients. C. difficile has also a highly diverse genome, which may contribute to its high virulence. Herein we ex...
Vos, S. Jasmijn Wijnker, Joris J. Overgaauw, Paul A. M.
Published in
International Journal of Environmental Research and Public Health
(1) Background: People with disabilities may benefit from an assistance dog (AD). Despite regulations that prohibit the denial of ADs to public places, this still occurs on a regular basis. The main argument for denial of access is that dogs compromise hygiene with their presence, which could cause a health hazard. Meanwhile, people are allowed to ...
van Rossen, Tessel M. van Dijk, Laura J. Heymans, Martijn W. Dekkers, Olaf M. Vandenbroucke-Grauls, Christina M. J. E.... van Beurden, Yvette H.
Published in
Therapeutic Advances in Gastroenterology
Background: One in four patients with primary Clostridioides difficile infection (CDI) develops recurrent CDI (rCDI). With every recurrence, the chance of a subsequent CDI episode increases. Early identification of patients at risk for rCDI might help doctors to guide treatment. The aim of this study was to externally validate published clinical pr...
Pham, Charles Dac Hua, Duong Tommy
Published in
Journal of Medical Case Reports
BackgroundClostridium difficile (C. difficile) is a common cause of infectious colitis in individuals with prior antibiotic or hospital exposure. Extraintestinal manifestations of C. difficile infections, however, are rare. Here we present a case of C. difficile appendicitis in an immunocompromised patient.Case presentationA 53-year-old Caucasian m...
Teja, Bijan Alibhai, Nafeesa Rubenfeld, Gordon D. Taggart, Linda R. Jivraj, Naheed Hirji, Sameer A. O’Gara, Brian P. Shaefi, Shahzad
Published in
Infectious Disease Reports
While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from Clostridioides difficile (formerly Clostridium difficile ) infection (CDI) has not been well studied in large cohorts. We sought to determine whether the combination of extreme leukocytosis and diarrhea was strongly predictive o...
Escudero-Sánchez, Rosa Ruiz-Ruigómez, María Fernández-Fradejas, Jorge García Fernández, Sergio Olmedo Samperio, María Cano Yuste, Angela Valencia Alijo, Angela Díaz-Pollán, Beatriz Rodríguez Hernández, María Jesús Merino De Lucas, Esperanza
...
Published in
Journal of Clinical Medicine
Bezlotoxumab is marketed for the prevention of recurrent Clostridioides difficile infection (rCDI). Its high cost could be determining its prescription to a different population than that represented in clinical trials. The objective of the study was to verify the effectiveness and safety of bezlotoxumab in preventing rCDI and to investigate factor...
