Xie, Simin Masokano, Ismail Bilal Liu, Wenguang Long, Xueying Li, Guijin Pei, Yigang Li, Wenzheng
Published in
European journal of radiology
To compare the clinical utility of single-shot echo-planar imaging (SS-EPI) using different breathing schemes and readout-segmented EPI (RS-EPI) in the repeatability of apparent diffusion coefficient (ADC) measurements, signal-to-noise ratio (SNR) and image quality. In this institutional review board-approved prospective study, hepatic DWIs (b = 50...
Vasseur, Antoine Kiavue, Nicolas Bidard, François-Clément Pierga, Jean-Yves Cabel, Luc
Published in
Molecular oncology
The prognostic role of circulating tumor cells (CTCs) has been clearly demonstrated in many types of cancer. However, their roles in diagnostic and treatment strategies remain to be defined. In this review, we present an overview of the current clinical validity of CTCs in non-metastatic and metastatic cancer, and the main studies or concepts inves...
Li, Rui Han, Dongsheng Shi, Jiping Han, YanXi Tan, Ping Zhang, Rui Li, Jinming
Published in
Biochimica et biophysica acta. Reviews on cancer
Immunotherapy has revolutionized the treatment of cancer due to its remarkable efficacy and extensive survival benefit in multiple tumor types. However, predictive biomarkers are required to identify patients who are likely to respond to immunotherapy. Recently, tumor mutational burden (TMB) has been shown to be associated with clinical outcomes in...
Yan, Yuanliang Guo, Guijie Huang, Jinzhou Gao, Ming Zhu, Qian Zeng, Shuangshuang Gong, Zhicheng Xu, Zhijie
Published in
Journal of Hematology & Oncology
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of onco...
Cwik, Bryan
Published in
Current Stem Cell Reports
Purpose of Review Continued development of gene editing techniques has raised the real possibility of clinical application of germline gene editing. These results, as well as reports of an unethical experiment which resulted in the birth of at least two children from edited embryos in 2018, have highlighted the urgency and importance of ethical iss...
Corso, Melissa Cancelliere, Carol Mior, Silvano Kumar, Varsha Smith, Ali Côté, Pierre
Published in
Chiropractic & Manual Therapies
IntroductionWhen indicated by signs or symptoms of potentially serious underlying pathology (red flags), chiropractors can use radiographs to inform their diagnosis. In the absence of red flags, the clinical utility of routine or repeat radiographs to assess the structure and function of the spine is controversial.ObjectivesTo determine the diagnos...
Boers, Jorianne de Vries, Erik F. J. Glaudemans, Andor W. J. M. Hospers, Geke A. P. Schröder, Carolina P.
Published in
Current Oncology Reports
Purpose of ReviewMolecular imaging with positron emission tomography (PET) is a powerful tool to visualize breast cancer characteristics. Nonetheless, implementation of PET imaging into cancer care is challenging, and essential steps have been outlined in the international “imaging biomarker roadmap.” In this review, we identify hurdles and provide...
Mo, Shaobo Zhou, Zheng Li, Yaqi Hu, Xiang Ma, Xiaoji Zhang, Long Cai, Sanjun Peng, Junjie
Published in
Cancer Cell International
BackgroundSurvival outcomes are significantly different in stage II colorectal cancer (CRC) patients with diverse clinicopathological features. The objective of this study is to establish a credible prognostic nomogram incorporating easily obtained parameters for stage II CRC patients.MethodsA total of 1708 stage II CRC patients seen at Fudan Unive...
Korwisi, Beatrice Treede, Rolf-Detlef Rief, Winfried Barke, Antonia
Published in
Pain Reports
Introduction: The purpose of the present ecological implementation field study is to evaluate the new classification of chronic pain as implemented in the 11th revision of the International Classification of Diseases ( ICD-11 ) with regard to clinical utility and interrater reliability. To evaluate the classification in a variety of settings, the s...
Motz, Benjamin M Baimas-George, Maria Barnes, T Ellis Ragunanthan, Branavan V Symanski, John D Christmas, A Britton Sing, Ronald F Ross, Samuel W
Published in
American journal of surgery
The clinical significance of obtaining cardiac troponin (cTn) levels among trauma patients with new onset arrhythmias is unknown. We aimed to assess whether cTn levels actually influence clinical decision making or represent an inappropriate use of resources. Trauma patients admitted from 2013 to 2014 diagnosed with atrial fibrillation (AF) were re...
