Sayed, Shomoita Nabi, A H M Nurun
Published in
Advances in experimental medicine and biology
Unveiling human genome through successful completion of Human Genome Project and International HapMap Projects with the advent of state of art technologies has shed light on diseases associated genetic determinants. Identification of mutational landscapes such as copy number variation, single nucleotide polymorphisms or variants in different genes ...
Chai, Chee-Shee Mos, Sumastika Bt Ng, Diana-Leh-Ching Goh, Greta-Miranda-Kim-Choo Su, Anselm-Ting Ibrahim, Muhammad Amin B. Musa, Aisya Natasya Bt Tan, Seng-Beng Pang, Yong-Kek Liam, Chong-Kin
...
Published in
BMC Pulmonary Medicine
BackgroundThe Spanish chronic obstructive pulmonary disease (COPD) guideline phenotypes patients according to the exacerbation frequency and COPD subtypes. In this study, we compared the patients’ health-related quality of life (HRQoL) according to their COPD phenotypes.MethodsThis was a cross-sectional study of COPD patients who attended the outpa...
van Buitenen, Nora van den Berg, Chantal J.W. Meijers, Jesse Harte, Joke M.
Published in
European Psychiatry
Background. Comorbidity has profound implications in both the clinical field and research, yet little is known about the prevalence and structure of comorbid mental disorders. This article aims not only to present data on the prevalence of mental disorders and comorbidity, but also to explore relationships between comorbid mental disorders by using...
Nettis, E Ortoncelli, M Pellacani, G Foti, C Di Leo, E Patruno, C Rongioletti, F Argenziano, G Ferrucci, S M Macchia, L
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Published in
Journal of investigational allergology & clinical immunology
Zeng, Yanping Liu, Yin Xie, Yanchun Liang, Jingjing Xiao, Zheman Lu, Zuneng
Published in
European Neurology
Objective: To analyze the clinical phenotypes and features of Guillain-Barré syndrome (GBS) in our hospital and explore the diagnostic value of the Brighton criteria. Methods: We retrospectively analyzed the clinical data of GBS patients hospitalized in our hospital from January 1, 2013, to September 30, 2016. The patients were affirmatively graded...
Grimaldi, Stephan Boucekine, Mohamed Witjas, Tatiana Fluchère, Frédérique Renaud, Mathilde Azulay, Jean-Philippe Guedj, Eric Eusebio, Alexandre
Published in
Parkinsonism & related disorders
The 2008 diagnostic criteria classify Multiple System Atrophy (MSA) patients in a predominantly parkinsonian (MSA-P) or cerebellar (MSA-C) type. Phenotypic descriptions have since highlighted a clinical heterogeneity among patients (e.g., mixed-type, cognitive impairment, atypical longer survival). This study attempts to identify different phenotyp...
Martínez-García, Miguel Angel Olveira, Casilda Máiz, Luis Girón, Rosa M ª Prados, Concepción de la Rosa, David Blanco, Marina Agustí, Alvar
Published in
Archivos de bronconeumologia
Most areas of respiratory medicine continue to use an Oslerian approach, based on signs and symptoms, in which the disease is the center of all activity. However, this paradigm is changing. Now that lung diseases have been recognized as heterogeneous and complex, we are moving towards more personalized, precise, patient-oriented medicine. The aim o...
Caio, Giacomo Volta, Umberto Sapone, Anna Leffler, Daniel A. De Giorgio, Roberto Catassi, Carlo Fasano, Alessio
Published in
BMC Medicine
BackgroundCeliac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options.Main bodyA major milestone in the history of celiac disease was the identification of tissue transglutaminase as the autoantigen, thereby confirming the autoimmune n...
Grimaldi, Stephan
Introduction : les critères diagnostiques de 2008 classent les patients atteints d'atrophie multi-systématisée (AMS) en une forme parkinsonienne prédominante (AMS-P) ou cérébelleuse prédominante (AMS-C). Les descriptions phénotypiques ont depuis mis en évidence une hétérogénéité clinique parmi les patients (description par exemple, d’une forme mixt...
Nelson, Lindsay D Kramer, Mark D Patrick, Christopher J McCrea, Michael A
Published in
Journal of the International Neuropsychological Society : JINS
Concussions cause diverse symptoms that are often measured through a single symptom severity score. Researchers have postulated distinct dimensions of concussion symptoms, raising the possibility that total scores may not accurately represent their multidimensional nature. This study examined to what degree concussion symptoms, assessed by the Spor...
