Wootton, Angie R McCuistian, Caravella Legnitto Packard, Dominique A Gruber, Valerie A Saberi, Parya
Background: Telehealth methods, including video chat counseling, have been growing in popularity within the behavioral health counseling field for over a decade. While video-based counseling methods have been shown to be effective and convenient, they have unique challenges stemming from the technology they use. Technical challenges can negatively ...
Hoenigl, Martin Little, Susan J Grelotti, David Skaathun, Britt Wagner, Gabriel A Weibel, Nadir Stockman, Jamila K Smith, Davey M
BackgroundTechnology has changed the way that men who have sex with men (MSM) seek sex. More than 60% of MSM in the United States use the internet and/or smartphone-based geospatial networking apps to find sex partners. We correlated use of the most popular app (Grindr) with sexual risk and prevention behavior among MSM.MethodsA nested cohort study...
Kewcharoenwong, Chidchamai Schuster, Gertrud U Wessells, K Ryan Hinnouho, Guy-Marino Barffour, Maxwell A Kounnavong, Sengchanh Brown, Kenneth H Hess, Sonja Y Samer, Waraporn Tussakhon, Inthira
...
BACKGROUND:Zinc deficiency impairs immune function and is common among children in South-East Asia. OBJECTIVES:The effect of zinc supplementation on immune function in young Laotian children was investigated. METHODS:Children (n = 512) aged 6-23 mo received daily preventive zinc tablets (PZ; 7 mg Zn/d), daily multiple micronutrient powder (MNP; 10 ...
Kaufmann, Timothy J Smits, Marion Boxerman, Jerrold Huang, Raymond Barboriak, Daniel P Weller, Michael Chung, Caroline Tsien, Christina Brown, Paul D Shankar, Lalitha
...
A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocacy groups to discuss challenges and potential solutions for increasing development of therapeutics for central nervous system metastases. A key issue identified at this meeting ...
Brenner, Andrew J Peters, Katherine B Vredenburgh, James Bokstein, Felix Blumenthal, Deborah T Yust-Katz, Shlomit Peretz, Idit Oberman, Bernice Freedman, Laurence S Ellingson, Benjamin M
...
BackgroundVB-111 is a non-replicating adenovirus carrying a Fas-chimera transgene, leading to targeted apoptosis of tumor vascular endothelium and induction of a tumor-specific immune response. This phase I/II study evaluated the safety, tolerability, and efficacy of VB-111 with and without bevacizumab in recurrent glioblastoma (rGBM).MethodsPatien...
Harvie, Heidi S Amundsen, Cindy L Neuwahl, Simon J Honeycutt, Amanda A Lukacz, Emily S Sung, Vivian W Rogers, Rebecca G Ellington, David Ferrando, Cecile A Chermansky, Christopher J
...
PurposeSacral neuromodulation and intradetrusor onabotulinumtoxinA injection are therapies for refractory urgency urinary incontinence. Sacral neuromodulation involves surgical implantation of a device that can last 4 to 6 years while onabotulinumtoxinA therapy involves serial office injections. We assessed the cost-effectiveness of 2-stage implant...
Held, Philip Klassen, Brian J Small, Charles F Brennan, Michael B Horn, Rebecca Van Karnik, Niranjan S Pollack, Mark H Zalta, Alyson K
Although evidence-based treatments for posttraumatic stress disorder (PTSD), such as Cognitive Processing Therapy (CPT), have been developed and widely disseminated, the rate of veterans engaging in and completing these therapies is low. Alternative methods of delivery may be needed to help overcome key barriers to treatment. Delivering evidence-ba...
Cloughesy, Timothy F Brenner, Andrew de Groot, John F Butowski, Nicholas A Zach, Leor Campian, Jian L Ellingson, Benjamin M Freedman, Laurence S Cohen, Yael C Lowenton-Spier, Noa
...
BackgroundOfranergene obadenovec (VB-111) is an anticancer viral therapy that demonstrated in a phase II study a survival benefit for patients with recurrent glioblastoma (rGBM) who were primed with VB-111 monotherapy that was continued after progression with concomitant bevacizumab.MethodsThis pivotal phase III randomized, controlled trial compare...
Patel, Sandip P Othus, Megan Chae, Young Kwang Giles, Francis J Hansel, Donna E Singh, Preet Paul Fontaine, Annette Shah, Manisha H Kasi, Anup Baghdadi, Tareq Al
...
PurposeImmune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).Patients and methodsWe performed a prospective, open-la...
Myers, Mark G Strong, David R Chen, Timothy C Linke, Sarah E
OBJECTIVE:To evaluate the efficacy of a brief telephone-delivered Motivational Interviewing (MI)-based intervention to facilitate engagement in evidence-based cessation treatment for Veterans with mental illness referred to smoking cessation treatment. METHODS:86 military Veteran smokers with mental illness were recruited from a tobacco cessation c...