Vanaken, Hilde Masand, Shirley N.
Published in
Therapeutic Innovation & Regulatory Science
BackgroundWhile the shift to digital technologies is pervasive across multiple industries, the informed consent process for clinical trials remains largely paper-based. Given the inefficiencies in the traditional process and the increasing complexity of clinical studies, the current approach at times may raise challenges with respect to quality, co...
Diesch, Katharina Held, Jürgen Kraus, Stefan Kunze, Ulrich Kraska, Detlef Prokosch, Hans-Ulrich
Published in
Studies in health technology and informatics
Antimycotics are substances to treat fungal infections, a frequent cause of death on intensive care units. It is of great importance to administer such drugs only to patients who actually need them, since the unnecessary application leads to the selection of multiresistent fungi, making future therapy more difficult, and represents a significant fi...
Guo, Junfei Luo, Yasha Wu, Yongbing Lai, Weiming Mu, Xiaoping
BACKGROUND: Preterm and low birth weight (birth weight
An, Xiujun Ye, Haiwang Chen, Junping Lu, Bo
BACKGROUND: In the present study, we aimed to determine the effect of different positive end-expiratory pressure (PEEP) levels on the cross-sectional area (CSA) of the right internal jugular vein (RIJV) and the overlap index between the RIJV and the right common carotid artery (RCCA) in mechanically ventilated patients with laryngeal mask airway (L...
Suranyi, Eva Nagy, Valeria Berta, Andras Matyus, Janos Szalai, Eszter Ujhelyi, Bernadett Meleg, Judit Damjanovich, Judit
BACKGROUND: The aim of this study was to present ophthalmological findings regarding Alport syndrome and report refractometry data and to present possible early signs of the syndrome. MATERIAL/METHODS: Seven patients suffering from Alport syndrome were referred to the Department of Ophthalmology at the University of Debrecen between January 1(st), ...
Xu, Mengda Wang, Changli Li, Na Wang, Jun Zhang, Yan Deng, Xiaoming
BACKGROUND: As a member of short-chain fatty acids, acetate exhibits anti-inflammatory capacity. The present study aimed to investigate the effect of acetate on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explored its underlying mechanism. MATERIAL/METHODS: Acetate (250 mM, 400 μL) was given intraperitoneally 30 minutes after LPS (...
Wang, Xiaolei Cao, Jingli Wang, Haichao Ye, Chen
BACKGROUND: This study investigated the risk factors of infliximab (IFX)-related infusion reactions (IR) in Chinese patients with inflammatory bowel disease (IBD). MATERIAL/METHODS: The medical records of 330 consecutive IBD patients treated with IFX between 2009 and 2017 were reviewed. The incidence of IR and adverse effects were recorded in detai...
Zhang, Huijun Yao, Bin Tang, Shengchun Chen, Ying
BACKGROUND: The functionality of LINK-A lncRNA as an oncogenic lncRNA has only been characterized in triple-negative breast cancer. The present study investigated the possible involvement of LINK-A in ovarian carcinoma. MATERIAL/METHODS: We enrolled 76 patients with ovarian carcinoma. Quantitative real-time PCR (qRT-PCR) was performed to analyze LI...
Bai, Yan Zhou, Qingyuan Fang, Qing Song, Liming Chen, Kai
BACKGROUND: It can be difficult to distinguish between bronchial asthma and chronic obstructive pulmonary disease (COPD) clinically, although these conditions are associated with different profiles of inflammatory cytokines and immune cells. This study aimed to compare T-lymphocyte subsets and inflammatory cytokines in the serum and sputum of patie...
Zhao, Min Li, Xiao Wan Chen, De Z. Hao, Fang Tao, Shu X. Yu, Hai Yan Cheng, Rui Liu, Hong
BACKGROUND: We investigated the effects of metformin on neurological function and oxidative stress in patients with type 2 diabetes mellitus with acute stroke. MATERIAL/METHODS: We randomly assigned 80 acute stroke patients to 2 groups: the metformin combined group and the insulin group. Each group had 40 patients and all were treated with standard...
