In contrast to humans that generate only a single type of polymer consisting of α2,8-linked N-acetylneuraminic acid polyNeu5Ac, fishes are able to generate a wide range of different polysialic acids varying according to teleosts order (Salmoniformes, Cypriniformes, …). While two human poly-α-2,8-sialyltransferases ST8Sia II and ST8Sia IV are respon...
The bacterial cell wall is a three-dimensional sugar and peptide network that surrounds the cell. It confers a cell shape adapted to the ecological niche of the bacterium, and protects the cell against mechanical stress exerted by the internal turgor pressure. In Gram-positive bacteria, such as the opportunistic human pathogen Streptococcus pneumon...
In the central nervous system, fast excitatory synaptic transmission is mainly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR). AMPAR are homo-tetrameric or hetero-tetrameric receptors assembled from different combinations of four core subunits, GluA1-4. These pore-forming subunits then form a macromolecular compl...
This work was dedicated to the synthesis of end-functional oligosaccharides to prepare novel bio-based surfactants. Starting from unprotected monosaccharides (mannose and glucose) or oligosaccharides (derived from cellulose), Fischer-glycosylation reaction with propargyl alcohol as glycosyl acceptor was utilized to functionalize the reducing-end of...
Published in Methods (San Diego, Calif.)
The use of RNA-seq as a generalized tool to measure the differential expression of genes has essentially replaced the use of the microarray. Despite the acknowledged technical advantages to this approach, RNA-seq library preparation remains mostly conducted by core facilities rather than in the laboratory due to the infrastructure, expertise and ti...
Different therapeutic strategies for the treatment of non-healing long bone defects have been intensively investigated. Currently used treatments present several limitations that have led to the use of biomaterials in combination with osteogenic growth factors, such as bone morphogenetic proteins (BMPs). Commonly used absorption or encapsulation me...
Les contaminations des surfaces constituent un problème majeur de santé public rencontré dans plusieurs secteurs tels que les milieux hospitaliers et l’industrie alimentaire. Cette contamination consiste en l’adhésion de bactéries pathogènes ou opportunistes qui peuvent former des biofilms. Ces biofilms sont potentiellement des sources de développe...
Published in Theranostics
Innovative and personalized therapeutic approaches result from the identification and control of individual aberrantly expressed genes at the transcriptional and post-transcriptional level. Therefore, it is of high interest to establish diagnostic, therapeutic and theranostic strategies at these levels. In the present study, we used the Diels-Alder...
L'interaction non-covalente entre un ligand et un récepteur selon un modèle clé-serrure constitue une des bases essentielles de tout système biologique. La présence de multiples clés et serrures sur les biomolécules conduit à des interactions multivalentes. Les lectines sont très fréquemment structurées en homo-multimères et sont donc des cibles de...
Published in International journal of medical sciences
Clinical experiences often document, that a successful tumor control requires high doses of drug applications. It is widely believed that unavoidable adverse reactions could be minimized by using gene-therapeutic strategies protecting the tumor-surrounding healthy tissue as well as the bone-marrow. One new approach in this direction is the use of "...
