Monchaud, David Pipier, Angélique
The existence and functional relevance of DNA and RNA G-quadruplexes (G4s) in human cells is now beyond debate, but how did we reach such a level of confidence? Thanks to a panoply of molecular tools and techniques that are now routinely implemented in wet labs. Among them, G4 imaging ranks high because of its reliability and practical convenience,...
Bakale, Rajubai D Phatak, Pramod S Rathod, Sanket S Choudhari, Prafulla B Rekha, Estharla Madhu Sriram, Dharmarajan Kulkarni, Ravibhushan S Haval, Kishan P
Published in
Journal of biomolecular structure & dynamics
In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives (4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have potent in vitro antitubercular activity against the Mycobacterium tuberculosis (MTB) H37Rv strain. Among these compounds, 4b, 4f, 4g, 4j, 4k, 4m, 4o, 4p, and 4r we...
Madegard, Léa Girard, Mélissa Blochouse, Estelle Riss-Yaw, Benjamin Palazzolo, Alberto Laquembe, Mélanie Audisio, Davide Poinot, Pauline Papot, Sebastien Taran, Frédéric
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The development of innovative strategies enabling chemical reactions in living systems is of great interest for exploring and manipulating biological processes. Herein, we present a pioneering approach based on both bioorthogonal and confined chemistry for intracellular drug synthesis. Exploiting a click-torelease reaction, we engineered nanopartic...
Schwarze, Thomas Müller, Holger Sperlich, Eric Kelling, Alexandra Holdt, Hans-Jürgen
Published in
ChemistryOpen
In this paper, we report on the sensing role of the 1,2,3-triazol unit in a 1,4-diyl arrangement in a fully π-conjugated fluorescent probe 1 (cf. Scheme 1) towards the fluorometric detection of 3d metal ions. The 1,2,3-triazol-1,4-diyl-fluoroionophore 1 was designed in a donor(D)-acceptor(A) arrangement with a 1,2,3-triazol unit as a π-linker betwe...
Zhang, Chao Tian, Tian Yin, Nanzhu Zhao, Jingjin
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Ampicillin (AMP) is a β-lactam antibiotic that can inhibit bacterial wall synthesis. The overuse and misuse of AMP makes it micropollutant that commonly found in food and various environmental media. In this work, a fluorescence polarization sensor was designed to sensitive detection of trace ampicillin based on click chemistry, using graphene oxid...
Falco, Natalie Griffin, Matthew E
Published in
Current opinion in chemical biology
Our microbiota plays crucial roles in immune development and homeostasis and has been implicated in virtually all major diseases of the 21st century. Nevertheless, our understanding of the exact microbial functions that underlie these correlations remains extremely limited, due in large part to the difficulty of profiling cellular activities within...
Liao, Yun Yan, Xi Zhu, Hui Zhou, Shuai Liao, Saihu
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
By virtue of the high reliability of click chemistry, polymers with clickable groups provide a useful platform for the rapid synthesis of polymer materials with diverse functionalities and architectures. However, the polymerization of clickable vinyl monomers with a concurrent regulation on tacticity remains underdeveloped. Herein, we report the su...
Kaur, Manpreet Bharti, Divya Kumar, Vinod Verma, Praveen Kumar Kumar, Rakesh
Published in
Molecular diversity
1,2,3-triazole is a vital structural motif of various drugs and therapeutic leads, as well as a linker for bioconjugation and molecular recognition. Cu-catalysed click cycloaddition of azides with terminal alkynes (CuAAc) is an important reaction to construct the triazole core. In recent years, various decarboxylative click strategies utilizing alk...
Li, Bao-Lin Li, Sitong Zhang, Cefei Zhou, Yuqiao Zhao, Xiaohu Yu, Zhipeng
Published in
Angewandte Chemie (International ed. in English)
Bioorthogonal click-release chemistry is a cutting-edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it is challenging to achieve the precise regulation or therapy of individual cells via click-release strategies driven by proximity and thermodynamics. Herein, we propose a novel photoclick-release...
Erdoğan, Musa Comert Onder, Ferah
Published in
Journal of biomolecular structure & dynamics
To create some novel anticancer molecules, a library of novel series of various triazoles linked to the hydroxyl group of 5,6,7,8-tetrafluoronaphthalen-1-ol (3) was designed and synthesized via CuAAC reaction 'Click Chemistry' of tetrafluoronaphthalene based terminal alkyne with substituted organic azides. The structural characterizations of the ta...
