Tian, Danfeng Guo, Yangyang Zhang, Dandan Gao, Qiang Liu, Ganlu Lin, Jingfeng Chang, Ze Wang, Yuchun Su, Rui Han, Zhenyun
...
Published in
Chinese Medicine
BackgroundSynaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endocytosis of synaptic vesicles in neurons and glutamate over accumulation. Previous researches have been confirmed that Shenzhi Ji...
Tarasenko, Daryna Meinecke, Michael
Published in
European Biophysics Journal
Cellular membranes can adopt a plethora of complex and beautiful shapes, most of which are believed to have evolved for a particular physiological reason. The closely entangled relationship between membrane morphology and cellular physiology is strikingly seen in membrane trafficking pathways. During clathrin-mediated endocytosis, for example, over...
Schechter, Meir Atias, Merav Abd Elhadi, Suaad Davidi, Dana Gitler, Daniel Sharon, Ronit
Published in
The Journal of Biological Chemistry
α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD). It is an intrinsically disordered protein that binds acidic phospholipids. Growing evidence supports a role for α-Syn in membrane trafficking, including, mechanisms of endocytosis and exocytosis, although the exact role of α-Syn in these mechanisms is curre...
Qin, Xin Zaki, Michael G. Chen, Zhicheng Jakova, Elisabet Ming, Zhi Cayabyab, Francisco S.
Published in
Molecular Neurobiology
Chronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and increased neuronal death. Still, the mechanisms responsible for this adenosine-mediated neuronal dam...
Hinze, Claudia McGourty, Kieran Boucrot, Emmanuel
Published in
Methods in molecular biology (Clifton, N.J.)
Quiescence (also called "G0") is the state in which cells have exited the cell cycle but are capable to reenter as required. Though poorly understood, it represents one of the most prevalent cell states across all life. Many biologically important cell types reside in quiescence including mature hepatocytes, endothelial cells, and dormant adult ste...
Maksymowicz, Małgorzata Miączyńska, Marta Banach-Orłowska, Magdalena
Published in
Cell Communication and Signaling
BackgroundLymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-inflammatory NF-κB and AP-1 pathways. Yet, the intracellular distribution of LTβR, the routes of its endocytosis and their connection...
Kroppen, Benjamin Teske, Nelli Yambire, King F. Denkert, Niels Mukherjee, Indrani Tarasenko, Daryna Jaipuria, Garima Zweckstetter, Markus Milosevic, Ira Steinem, Claudia
...
Published in
Cellular and Molecular Life Sciences
Membrane remodeling is a critical process for many membrane trafficking events, including clathrin-mediated endocytosis. Several molecular mechanisms for protein-induced membrane curvature have been described in some detail. Contrary, the effect that the physico-chemical properties of the membrane have on these processes is far less well understood...
Nobile, B Durand, M Courtet, P Van de Perre, P Nagot, N Molès, J P Olié, E
Published in
Schizophrenia research
Johnson, Alexander Gnyliukh, Nataliia Kaufmann, Walter A Narasimhan, Madhumitha Vert, Grégory Bednarek, Sebastian Y Friml, Jiří
Published in
Journal of cell science
Clathrin-mediated endocytosis (CME) is a crucial cellular process implicated in many aspects of plant growth, development, intra- and intercellular signaling, nutrient uptake and pathogen defense. Despite these significant roles, little is known about the precise molecular details of how CME functions in planta To facilitate the direct quantitative...
Briant, Kit Redlingshöfer, Lisa Brodsky, Frances M
Published in
Current opinion in cell biology
Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways to differentiation, disease and physiological processes such as glucose metabolism are reviewed. Diversity and comm...
