Hamesch, Karim Guldiken, Nurdan Aly, Mahmoud Hüser, Norbert Hartmann, Daniel Rufat, Pierre Ziol, Marianne Remih, Katharina Lurje, Georg Scheiner, Bernhard
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Published in
BMC Medicine
BackgroundKeratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells. K18-based serum fragments are commonly used liver disease predictors, while K19-based serum fragments detected through CYFRA21-1 are establ...
Desai, Archita P Knapp, Shannon M Orman, Eric S Ghabril, Marwan S Nephew, Lauren D Anderson, Melissa Ginès, Pere Chalasani, Naga P Patidar, Kavish R
Published in
Journal of hepatology
Acute kidney injury (AKI) is a significant clinical event in cirrhosis yet contemporary population-based studies on the impact of AKI on hospitalized cirrhotics are lacking. We aimed to characterize longitudinal trends in incidence, healthcare burden and outcomes of hospitalized cirrhotics with and without AKI using a nationally representative data...
Chiang, Ryan S Parish, Alice Niedzwiecki, Donna Kappus, Matthew R Muir, Andrew J
Published in
Digestive diseases and sciences
Malnutrition is common in patients with cirrhosis and is associated with poor outcomes after hepatic resection and liver transplantation. Transjugular intrahepatic portosystemic shunt (TIPS) is performed for complications of cirrhosis. To assess the impact of malnutrition on TIPS outcomes. A retrospective analysis was performed using the Healthcare...
Mazumder, Nikhilesh R Celaj, Stela Atiemo, Kofi Daud, Amna Jackson, Kathryn L Kho, Abel Levitsky, Josh Ladner, Daniela P
Published in
Journal of hepatology
Sex-based differences are known to significantly contribute to outcomes in patients with chronic liver diseases; however, the role of patient sex in cirrhosis is unclear. We aimed to study the relationship between patient sex and cirrhosis. We analyzed a cohort of 20,045 patients with cirrhosis using a Chicago-wide electronic health record database...
Trebicka, Jonel Gu, Wenyi Ibáñez-Samaniego, Luis Hernández-Gea, Virginia Pitarch, Carla Garcia, Elisabet Procopet, Bogdan Giráldez, Álvaro Amitrano, Lucio Villanueva, Candid
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Published in
Journal of hepatology
The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of transjugular intrahepatic portosystemic shunt (TIPS) in the management in patients with ACLF has not been described to date. A m...
Philips, Cyriac Abby Ahamed, Rizwan Rajesh, Sasidharan George, Tom Mohanan, Meera Augustine, Philip
Published in
BMC Gastroenterology
Gastric varices are encountered less frequently than esophageal varices. Nonetheless, gastric variceal bleeding is more severe and associated with worse outcomes. Conventionally, gastric varices have been described based on the location and extent and endoscopic treatments offered based on these descriptions. With improved understanding of portal h...
Yang, Xiu-An Lv, Fengchun Wang, Ran Chang, Yange Zhao, Yiming Cui, Xinyu Li, Haochen Yang, Sixi Li, Suting Zhao, Xuemin
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Published in
Gut Pathogens
BackgroundIncreasing evidence demonstrate that the gut microbiota is involved in the pathogenesis of liver diseases, and faecal microbiota transplantation is considered to be a promising new treatment option. However, there are no reports on the intestinal flora of asymptomatic HBV carriers using next-generation sequencing. This study intends to in...
Peng, Dan Xing, Hai-Yan Li, Chen Wang, Xian-Feng Hou, Min Li, Bin Chen, Jian-Hong
Published in
BMC Gastroenterology
BackgroundPrevious studies have demonstrated the benefits of thymosin alpha-1 (Tα1) in anti-virus, immunological enhancement and anti-inflammation. However, it is controversial about the efficacy and safety of entecavir (ETV) plus Tα1 combination therapy versus ETV monotherapy in cirrhotic patients with hepatitis B virus (HBV) infection.MethodsThe ...
Claude, Caroline Deep, Akash Kneyber, Martin Siddiqui, Salman Renolleau, Sylvain Morin, Luc Jacquemin, Emmanuel Teglas, Jean-Paul Gajdos, Vincent Tissières, Pierre
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Published in
Annals of Intensive Care
Background and aimsData on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensive Care Units (PICU).MethodsWe performed a multicentre retrospective analysis of children with cirrhosis admitted into fou...
Mukherjee, Sandeep
Published in
World Journal of Gastroenterology
Nonalcoholic steatohepatitis (NASH) is an important indication for liver transplantation in many Western countries due to the epidemic of obesity and insulin resistance. Unfortunately, no medication is approved for NASH and risk factor modification is often advised. Over the last decade, several clinical trials on NASH have been conducted with seve...
