Annals of medicine
Daytime variation with regard to onset time of ST-elevation myocardial infarction (STEMI) symptoms has been observed. Nevertheless, with the advanced medical therapy, it is not uncertainty if a similar circadian pattern of STEMI symptom onset occurs, as well as its possible impact on clinical outcomes. Few long-term data are available. We assess th...
Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of luciferase enzymatic activity. Second, to comply with EMA and FDA guidelines to mitigate drug-drug interact...
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
In multiple studies, the potential relationship between daylight saving time (DST) and the occurrence of acute myocardial infarction (MI) has been investigated, with mixed results. Using the Dutch Percutaneous Coronary Intervention (PCI) registry facilitated by the Netherlands Heart Registration, we investigated whether the transitions to and from ...
Journal of the Academy of Nutrition and Dietetics
Social jetlag (SJL) occurs in adolescents due to misalignment of the biological and social clocks, so that most teens wake up earlier than their biological clocks on weekdays and delay bedtime and wake up time on weekends. This shift in sleep timing among adolescents is associated with an adverse endocrine and behavioral risk profile, in addition t...
BMC Complementary Medicine and Therapies
BackgroundIntegrating systems biology is an approach for investigating metabolic diseases in humans. However, few studies use this approach to investigate the mechanism by which Rhizoma coptidis (RC) reduces the effect of lipids and glucose on high-fat induced obesity in rats.MethodsTwenty-four specific pathogen-free (SPF) male Sprague–Dawley rats ...
Biochimica et biophysica acta. Molecular and cell biology of lipids
Disruption of circadian (~24 h) rhythms is associated with an increased risk of cardiometabolic diseases. Therefore, unravelling how circadian rhythms are regulated in different metabolic tissues has become a prominent research focus. Of particular interest is brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose i...
S. Ray and A. Reddy recently anticipated the implication of circadian rhythm in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of the coronavirus disease (Covid-19). In addition to its key role in the regulation of biological functions, the circadian rhythm has been suggested as a regulator of viral infec...
BackgroundSleep disorders are composed of a group of diseases of increasing prevalence and with social-health implications to be considered a public health problem. Sleep habits and specific sleep behaviors have an influence on the academic success of students. However, the characteristics of sleep and sleep habits of university students as predict...
Neurobiology of Sleep and Circadian Rhythms
• In rodents, males spend less time awake, and more time in NREMS than females. • The recovery from sleep deprivation is also dependent on biological sex. • Gonadal hormones modulate sleep and circadian phenotypes in rodents. • A more systematic comparison of sex in basic sleep/circadian research is needed.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology