Vermehren, M F Wiesmann, N Deschner, J Brieger, J Al-Nawas, B Kämmerer, P W
Published in
Toxicology in vitro : an international journal published in association with BIBRA
Human gingival fibroblasts (HGF) play a vital role in wound healing, oral cancer, and are among the first cells being exposed to e-cigarette vapor (eCV) or cigarette smoke (CS) during inhalation. Although the cell-damaging effect of CS has been well studied, the effects of eCV on gingival cells are still unclear. The aim of this in vitro study was ...
Taylor, Mark Santopietro, Simone Baxter, Andrew East, Nicole Breheny, Damien Thorne, David Gaça, Marianna
Published in
BMC Research Notes
ObjectivesCigarette smoke aqueous aerosol extracts (AqE) have been used for assessing tobacco products, particularly with in vitro models such as oxidative stress and inflammation. These test articles can be generated easily, but there are no standardised methods for the generation and characterisation or stability. We investigated the effects of p...
Kaur, Gagandeep Batra, Sanjay
Published in
Cell biology and toxicology
Chronic obstructive pulmonary disease (COPD) is a global health problem. Currently, there is a lack of knowledge about the pathobiology of this disease and available therapies are ineffective. Cigarette smoking is the leading cause of COPD; however, not all smokers develop COPD. Exacerbations of COPD caused by microbes are common and detrimental. A...
He, Patrick Gelissen, Ingrid C. Ammit, Alaina J.
Published in
Respiratory Research
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has been realised. These studies p...
Mohammadtursun, Nabijan Li, Qiuping Abuduwaki, Muhammadjan Jiang, Shan Zhang, Hu Sun, Jing Dong, Jingcheng
Published in
Chinese Medicine
BackgroundLoki zupa formula is kind of a traditional medicines which used to treat airway diseases, especially those caused by abnormal phlegm, such as cough, asthma and chronic bronchitis. The study aim was to explore the anti-inflammatory and anti-remodeling effects of Loki zupa by using a cigarette-smoke induced rat model of chronic obstructive ...
Aspera-Werz, Romina H Ehnert, Sabrina Müller, Monja Zhu, Sheng Chen, Tao Weng, Weidong Jacoby, Johann Nussler, Andreas K
Published in
World Journal of Stem Cells
BACKGROUND Cigarette smoking (CS) is the most common method of consuming tobacco. Deleterious effects on bone integrity, increased incidence of fractures, and delayed fracture healing are all associated with CS. Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and, via the blood...
Wang, Jin Chen, Tao Yu, Xiaofan OUYang, Nan Tan, Lirong Jia, Beibei Tong, Jian Li, Jianxiang
Published in
Journal of Translational Medicine
BackgroundLung cancer is one of the most common carcinomas in the world, and lung adenocarcinoma (LUAD) is the most lethal and most common subtype of lung cancer. Cigarette smoking is the most leading risk factor of lung cancer, but it is still unclear how normal lung cells become cancerous in cigarette smokers. This study aims to identify potentia...
Wang, Xiaoyun Zhang, Duo Higham, Andrew Wolosianka, Sophie Gai, Xiaoyan Zhou, Lu Petersen, Hans Pinto-Plata, Victor Divo, Miguel Silverman, Edwin K.
...
Published in
Respiratory Research
BackgroundA disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known.MethodsADAM15 gene expression and/or protein levels were measured in whole lung and bronchoalveolar lavage (BAL) macrophage samples obtaine...
Manevski, Marko Muthumalage, Thivanka Devadoss, Dinesh Sundar, Isaac K Wang, Qixin Singh, Kameshwar P Unwalla, Hoshang J Chand, Hitendra S Rahman, Irfan
Published in
Redox biology
The abnormal inflammatory responses due to the lung tissue damage and ineffective repair/resolution in response to the inhaled toxicants result in the pathological changes associated with chronic respiratory diseases. Investigation of such pathophysiological mechanisms provides the opportunity to develop the molecular phenotype-specific diagnostic ...
Seelan, Ratnam S. Greene, Robert M. Pisano, Michele M.
Published in
Microrna (Shariqah, United Arab Emirates)
The adverse developmental effects of exposure to Cigarette Smoke (CS) during pregnancy are documented in this paper. These include low birth weight, congenital anomalies, preterm birth, fetal mortality and morbidity. The current biological thought now recognizes that epigenetics represents a fundamental contributing process in embryogenesis, and th...
