Published in IDCases
Patients with primary immunodeficiency disease (PID) are not only vulnerable to mycobacterial disease, but are also more likely to develop adverse events following BCG vaccination. These events can range from regional disease (BCGitis) to disseminated disease (BCGosis). Chronic granulomatous disease (CGD), which is characterized by impaired leukocy...
Published in New Microbes and New Infections
We report a case of a soft-tissue infection with Francisella philomiragia , a rare opportunistic pathogen in individuals with chronic granulomatous disease.
Published in Journal of clinical immunology
Published in Respiratory Medicine Case Reports
Chronic granulomatous disease (CGD) is caused by gene mutations that affect the phagocyte NADPH oxidase. This results in recurrent infections by catalase-positive bacteria or fungi. Here, we report a case of X-linked CGD presenting a mixed infection with Burkholderia cepacia and Aspergillus . A novel mutation was found by bioinformatics analyses of...
Published in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Patients with chronic granulomatous disease (CGD) develop severe infections, including Bacillus Calmette-Guérin (BCG). Although the autosomal recessive CGD (AR-CGD) patients should hypothetically develop relatively fewer infections compared to the X-linked CGD (X-CGD) patients due to more residual reactive oxygen intermediates, the impacts of BCG v...
Published in International Archives of Allergy and Immunology
Background: Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease. Methods: Icotinamide adenine...
Published in Journal of clinical immunology
Haploidentical related donor (HRD) transplantation was performed in 7 recipients with chronic granulomatous disease (CGD) who had no matched-related or unrelated donor. Peripheral blood cell (PBC) products were used with a conditioning regimen consisting of low-dose cyclophosphamide, fludarabine, total body irradiation, and busulfan. Graft-versus-h...
Published in Medical Mycology Case Reports
• Mucormycosis isolated to the mandible is a rare presentation, occurring generally after dental procedures. • Self-extraction of teeth as in our patient can result in isolated mucormycosis of the mandible. • Isolated mucormycosis of the mandible can be a presenting symptom of chronic granulomatous disease. • Combination of medical and surgical tre...
Published in Methods in molecular biology (Clifton, N.J.)
Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects and other disorders of ch...
Published in Free radical biology & medicine
Reactive oxygen species (ROS) produced in hematopoietic stem cells (HSCs) are involved in the balance between quiescence, self-renewal, proliferation and differentiation processes. However the role of NOX enzymes on the early stages of hematopoietic differentiation is poorly investigated. For that, we used induced pluripotent stem cells (iPSCs) der...
