Published in Scientific Reports
Invasive fungal infections mainly affect patients undergoing transplantation, surgery, neoplastic disease, immunocompromised subjects and premature infants, and cause over 1.5 million deaths every year. The most common fungi isolated in invasive diseases are Candida spp ., Cryptococcus spp ., and Aspergillus spp. and even if four classes of antifun...
Published in Heliyon
Transferrin; Glycoforms; Sialic acid; Chromatography; UV-Vis spectroscopy; Molar absorbance.
Devido à alta demanda por estratégias de controle de pragas agrícolas mais sustentáveis, muitos estudos têm sido direcionados para investigar metabólitos biocidas em biomassas. A aveia preta(Avena strigosa) está entre as espécies promissoras para a produção de pesticidas naturais. A determinação do processo de extração e a escolha da metodologia an...
A Crotalaria juncea é uma espécie originária da Ásia Tropical e apresenta diversas aplicações, destacando-se sua utilização como fertilizante natural. Tanto efeitos tóxicos quanto efeitos benéficos desta planta podem estar relacionados à presença de compostos químicos com atividade antioxidante, fitotóxica ou antifúngica. Portanto, a investigação d...
O gênero Crotalaria possui, em geral, alcaloides de elevada toxicidade aos vertebrados. Crotalaria juncea é uma das espécies desta família e tem sido utilizada na adubação verde e no controle de pragas. Com isso, surge o interesse em identificar os principais metabólitos secundários presentes em extratos de sementes de C. juncea. Este trabalho util...
Published in Materials and Structures
Asphalt binder is a complex compound comprising a diverse and intricate range of hydrocarbons which makes it difficult to accurately ascertain its chemical structure. This study aimed to analyze the chemical composition of asphalt binder and establish an accurate molecular structure model of unaged asphalt binder fractions. An unaged asphalt binder...
Published in Scientific Reports
The C1q superfamily includes proteins involved in innate immunity, insulin sensitivity, biomineralization and more. Among these proteins is otolin-1, which is a collagen-like protein that forms a scaffold for the biomineralization of inner ear stones in vertebrates. The globular C1q-like domain (gC1q), which is the most conserved part of otolin-1, ...
Replication of the ∼30 kb-long coronavirus genome is mediated by a complex of non-structural proteins (NSP), in which NSP7 and NSP8 play a critical role in regulating the RNA-dependent RNA polymerase (RdRP) activity of NSP12. The assembly of NSP7, NSP8 and NSP12 proteins is highly dynamic in solution, yet the underlying mechanism remains elusive. W...
Published in Archives of Razi Institute
In the last couple of years, a number of new and rapid tests for the diagnosis of Tuberculosis (TB) have been developed based on the low molecular weight antigens from Mycobacterium Tuberculosis ( Mtb ) culture supernatant. This study aimed to isolate and purify low molecular weight antigens secreted by Mtb strain C for diagnostic purpose. The secr...
BackgroundAs global confirmed cases and deaths from coronavirus disease 2019 (COVID-19) surpass 100 and 2.2 million, respectively, quantifying the effects of the widespread treatment of remdesivir (GS-5734, Veklury) and the steroid dexamethasone is becoming increasingly important. Limited pharmacokinetic studies indicate that remdesivir concentrati...
