Moussa, Magdy Elshorbagy, Muhammed Sameh Emarah, Ayman Gaber, Raouf Moussa, Omar M. El-Bradey, Mohamed Alagorie, Ahmed Roshdy Sorour, Osama A.
Published in
International Ophthalmology
Background The aims of this study were to provide real-life data about the effect of COVID-19 pandemic on the practice of anti-VEGF injections and to evaluate the safety of the modifications in the injection protocol imposed during the ongoing pandemic on the anatomical and functional outcome of patients. Methods All patients attending Tanta Univer...
Siedlecki, Jakob Koch, Caroline Schworm, Benedikt Liegl, Raffael Kreutzer, Thomas Kortuem, Karsten U. Schumann, Ricarda Priglinger, Siegfried G. Wolf, Armin
Published in
BMC Ophthalmology
BackgroundTo study the enlargement rate of primary geographic atrophy (GA) before and after diagnosis of a secondary choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (VEGF) therapy.MethodsFive hundred twenty-two consecutive eyes with primary GA were screened for the development of a complicating secondary CNV....
Kniggendorf, Vinicius Dreyfuss, Juliana L Regatieri, Caio V
ABSTRACT Age-related macular degeneration is the leading cause of vision loss in elderly individuals, as well as a medical and socio-economic challenge. The treatment of dry age-related macular degeneration is based on vitamin supplementation. New treatment studies are focused on preventing the progression of degeneration and repopulating the atrop...
Li, Longhui Lai, Kunbei Li, Cong Gong, Yajun Xu, Fabao Zhao, Hongkun Zhou, Lijun Huang, Chuangxin Jin, Chenjin
Published in
Cutaneous and ocular toxicology
To explore the effect and mechanism of APRPG-modified nanoliposomes loaded with miR-146a-5p inhibitor (ANL-miR-146a-5p inhibitor) on endothelial cell proliferation, migration, tube formation, and choroidal neovascularization (CNV) in mice. ANL-miR-146a-5p inhibitors were generated by thin film hydration; in vitro, endothelial cell uptake experiment...
Nawar, Amin E. Shafik, Heba M.
Published in
BMC Ophthalmology
BackgroundMyopic choroidal neovascularization (CNV) is the most common sight-threatening complication associated with high myopia. The present study evaluated the efficacy and safety of the intravitreal injection of ziv-aflibercept in patients with myopic CNV.MethodsThis prospective interventional study was conducted on 20 eyes of 20 patients with ...
Ito, Taiju Igarashi-Yokoi, Tae Shinohara, Kosei Yoshida, Takeshi Ohno-Matsui, Kyoko
Published in
BMC Ophthalmology
BackgroundTo report a rare case of pathologic myopia in which a choroidal neovascularization (CNV) induced a hemorrhagic macular hole retinal detachment (MHRD), and then both the CNV and MHRD disappeared simultaneously in 5 days.Case presentationA 76-year-old man with pathologic myopia complained of distorted vision in his left eye of 1-week durati...
Chang, Yo-Chen Lin, Chia-Wei Chang, Yuh-Shin Chen, Po-Han Li, Chia-Yang Wu, Wen-Chuan Kao, Ying-Hsien
Published in
Life sciences
Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19 cells. ARPE-19 cells were exposed ...
Lai, Kunbei Gong, Yajun Zhao, Wenbo Li, Longhui Huang, Chuangxin Xu, Fabao Zhong, Xiaojing Jin, Chenjin
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
To investigate whether triptolide has inhibitory effects on the development of choroidal neovascularization (CNV), together with its underlying anti-angiogenic mechanisms. CNV was induced in C57BL/6 J mice using laser photocoagulation. Triptolide at concentrations of 0.035 and 0.07 mg/kg body weight (BW) or the same volume of phosphate-buffered sal...
Wang, Wei Chen, Wei Bai, Xinyue Chen, Ling
Published in
BMC Ophthalmology
BackgroundBietti crystalline dystrophy (BCD) is a distinct entity of retinitis pigmentosa with a wide range of genotypic and phenotypic variabilities. The goal of the present study was to investigate the morphological, functional and genetic features of BCD.MethodsA full series of multimodal imaging was performed in four Chinese patients with BCD, ...
Singh, Rupesh Batoki, Julia C Ali, Mariya Bonilha, Vera L Anand-Apte, Bela
Published in
Nanomedicine : nanotechnology, biology, and medicine
Choroidal neovascularization (CNV) is the abnormal growth of blood vessels that sprout from the choroid vasculature and grow beneath and into the retina. The newly formed blood vessels in CNV often leak blood and fluid which deteriorates vision over time, eventually leading to blindness. In the present study, we examined the efficacy of intravenous...
