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with Cholesterol homeostasis as keyword

Linking phytosterols and oxyphytosterols from food to brain health: origins, effects, and underlying mechanisms.

Published in Critical reviews in food science and nutrition

Phytosterols and their oxidation products, namely oxyphytosterols, are natural compounds present in plant foods. With increased intake of phytosterol-enriched functional food products, the exposure of both phytosterols and oxyphytosterols is rising. Over the past ten years, researches have been focused on their absorption and metabolism in human bo...

Effect of rosuvastatin on the concentration of each fatty acid in the fraction of free fatty acids and total lipids in h...

Published in Biochemistry and Biophysics Reports

• Rosuvastatin decreased the concentration of total fatty acids and free fatty acids. • The change in the concentration of each fatty acid was analyzed. • Changes in fatty acid concentrations are part of cholesterol homeostasis. • These changes bring beneficial consequences in cardiovascular diseases.

The effects of statins with a high hepatoselectivity rank on the extra-hepatic tissues; New functions for statins.

Published in Pharmacological research

Statins, as the most common treatment for hyperlipidemia, exert effects beyond their lipid-lowering role which are known as pleiotropic effects. These effects are mainly due to the inhibition of isoprenoids synthesis and consequently blocking prenylation of proteins involved in the cellular signaling pathways regulating cell development, growth, an...

The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer.

Published in Seminars in cancer biology

Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in a plethora of tumors. More recent evidence indicates additional contribution of these transporters to other processes, such as tumor cell dissemination and metastasis, thereby extending their possible roles in tumor progression. While the role of some ABC tra...

Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

The brain is isolated from the whole body by the blood-brain barrier (BBB) which is located in brain microvessel endothelial cells (ECs). Through physical and metabolic properties induced by brain pericytes, astrocytes and neurons (these cells and the ECs referred to as the neurovascular unit (NVU)), the BBB hardly restricts exchanges of molecules ...

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Published in Journal of cell science

The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell physiology. The ER membrane protein complex (EMC) is a newly described transmembrane domain (TMD) insertase linked with various phenotypes, but whose clients and cellular responsi...

Oral administration of palatinose vs sucrose improves hyperglycemia in normal C57BL/6J mice.

Published in Nutrition research (New York, N.Y.)

Palatinose is a sucrose analog with a slower digestion rate than that of sucrose. For this reason, palatinose shows better effects on hepatic lipogenesis and cholesterol homeostasis compared with sucrose. We hypothesized that supplementation with palatinose instead of sucrose improves postprandial hyperglycemia and hyperinsulinemia in mice. Herein,...