Yao, Weilong Jiao, Yue Zhou, Yanhua Luo, Xiaoya
Published in
Cell & Bioscience
BackgroundColorectal cancer (CRC) is the fourth most deadly malignancy throughout the world. Extensive studies have shown that Krüppel-like factors (KLFs) play essential roles in cancer development. However, the function of KLF13 in CRC is unclear.MethodsThe Cancer Genome Atlas database was applied to analyze the expression of KLF13 in CRC and norm...
Che, Li Chi, Wenna Qiao, Yu Zhang, Jie Song, Xinhua Liu, Ye Li, Lei Jia, Jiaoyuan Pilo, Maria G Wang, Jingxiao
...
Published in
Gut
Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). We investigated the functional contribution of fatty acid synthase (Fasn)-mediated de novo FA synthesis in a murine HCC model induced by loss of Pten and overexpression of c-Met (...
Bhardwaj, Anjana Singh, Harpreet Trinidad, Celestine Marie Albarracin, Constance T. Hunt, Kelly K. Bedrosian, Isabelle
Published in
Breast Cancer Research
BackgroundPrevention of triple-negative breast cancer (TNBC) is hampered by lack of knowledge about the drivers of tumorigenesis.MethodsTo identify molecular markers and their downstream networks that can potentially be targeted for TNBC prevention, we analyzed small RNA and RNA sequencing of a cell line model that represent early stages of TNBC de...
Jayamanne, Chamara Sandamal, Sajith Jayasundara, Kasun Saranavabavananthan, Mayoorathy Mettananda, Sachith
Published in
Journal of Medical Case Reports
BackgroundSmith–Lemli–Opitz syndrome is a rare autosomal recessive disorder of cholesterol biosynthesis which is characterized by multiple congenital malformations and global developmental delay. Here we report the case of a 3-year-old, previously undiagnosed, child with Smith–Lemli–Opitz syndrome presenting with acute adrenal crisis, which is an e...
Sabino, Marcella Cappelli, Katia Capomaccio, Stefano Pascucci, Luisa Biasato, Ilaria Verini-Supplizi, Andrea Valiani, Andrea Trabalza-Marinucci, Massimo
Published in
BMC Genomics
BackgroundThe Mediterranean diet is considered one of the healthier food habits and olive oil is one of its key components. Olive oil polyphenols are known to induce beneficial effects in several pathological conditions, such as inflammatory bowel disease, and to contrast the proliferation of cancer cells or hypercholesterolemia. Polyphenols are al...
Genaro-Mattos, Thiago C Tallman, Keri A Allen, Luke B Anderson, Allison Mirnics, Karoly Korade, Zeljka Porter, Ned A
Published in
Toxicology and applied pharmacology
While antipsychotic medications provide important relief from debilitating psychotic symptoms, they also have significant adverse side effects, which might have relevant impact on human health. Several research studies, including ours, have shown that commonly used antipsychotics such as haloperidol and aripiprazole affect cholesterol biosynthesis ...
Johnson, Steven W. Thompson, Dorothea K. Raccor, Brianne
Published in
Current Infectious Disease Reports
Purpose of ReviewDirect-acting antiviral agents (DAAs) have markedly improved the prognosis of hepatitis C virus (HCV)-genotype 3 (GT3), a highly prevalent infection worldwide. However, in patients with hepatic fibrosis, cirrhosis, or hepatocellular carcinoma (HCC), GT3 infection presents a treatment challenge compared with other genotypes. The dep...
Yarmishyn, Aliaksandr A. Kremenskoy, Maksym Batagov, Arsen O. Preuss, Axel Wong, Jin Huei Kurochkin, Igor V.
Published in
BMC Genomics
BackgroundRNA is often targeted to be localized to the specific subcellular compartments. Specific localization of mRNA is believed to be an important mechanism for targeting their protein products to the locations, where their function is required.ResultsIn this study we performed the genome wide transcriptome analysis of peroxisome preparations f...
Driver, Ashley M Kratz, Lisa E Kelley, Richard I Stottmann, Rolf W
Published in
Neurobiology of disease
We previously reported a mutation in the cholesterol biosynthesis gene, hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7(rudolph)), that results in striking embryonic forebrain dysgenesis. Here we describe abnormal patterns of neuroprogenitor proliferation in the mutant forebrain, namely, a decrease in mitotic cells within the ventricular zone (VZ...
Driver, Ashley M Kratz, Lisa E Kelley, Richard I Stottmann, Rolf W
Published in
Neurobiology of disease
We previously reported a mutation in the cholesterol biosynthesis gene, hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7(rudolph)), that results in striking embryonic forebrain dysgenesis. Here we describe abnormal patterns of neuroprogenitor proliferation in the mutant forebrain, namely, a decrease in mitotic cells within the ventricular zone (VZ...
