Ratnayake, Ruwan Finger, Flavio Edmunds, W. John Checchi, Francesco
Published in
BMC Medicine
BackgroundCholera epidemics continue to challenge disease control, particularly in fragile and conflict-affected states. Rapid detection and response to small cholera clusters is key for efficient control before an epidemic propagates. To understand the capacity for early response in fragile states, we investigated delays in outbreak detection, inv...
Morgan, Winthrop Levin, Ann Hutubessy, Raymond Cw Mogasale, Vittal
Published in
Human vaccines & immunotherapeutics
Cholera is both an endemic and epidemic disease in many low and middle-income countries (LMICs). Strategies for cholera control include improving water, sanitation, and hygiene; providing early and effective treatment; and deploying oral cholera vaccine (OCV). This last strategy is relatively new, and countries considering its introduction are inte...
Bompangue, Didier Moore, Sandra Taty, Nadège Impouma, Benido Sudre, Bertrand Manda, Richard Balde, Thierno Mboussou, Franck Vandevelde, Thierry
Published in
BMC Infectious Diseases
BackgroundRapid control of cholera outbreaks is a significant challenge in overpopulated urban areas. During late-2017, Kinshasa, the capital of the Democratic Republic of the Congo, experienced a cholera outbreak that showed potential to spread throughout the city. A novel targeted water and hygiene response strategy was implemented to quickly ste...
Tilahun, Getachew Teshome Woldegerima, Woldegebriel Assefa Wondifraw, Aychew
Published in
Advances in Difference Equations
In this paper we develop a stochastic mathematical model of cholera disease dynamics by considering direct contact transmission pathway. The model considers four compartments, namely susceptible humans, infectious humans, treated humans, and recovered humans. Firstly, we develop a deterministic mathematical model of cholera. Since the deterministic...
Monje, Fred Ario, Alex Riolexus Musewa, Angella Bainomugisha, Kenneth Mirembe, Bernadette Basuta Aliddeki, Dativa Maria Eurien, Daniel Nsereko, Godfrey Nanziri, Carol Kisaakye, Esther
...
Published in
Infectious Diseases of Poverty
BackgroundOn 23 February 2018, the Uganda Ministry of Health (MOH) declared a cholera outbreak affecting more than 60 persons in Kyangwali Refugee Settlement, Hoima District, bordering the Democratic Republic of Congo (DRC). We investigated to determine the outbreak scope and risk factors for transmission, and recommend evidence-based control measu...
Akrimajirachoote, Nattaphong Satitsri, Saravut Sommart, Ubonta Rukachaisirikul, Vatcharin Muanprasat, Chatchai
Published in
European journal of pharmacology
Secretory diarrhea is one of the most common types of diarrhea with high morbidity and mortality. Previous studies showed that inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels alleviated fluid loss in secretory diarrheas. This study aimed to identify novel CFTR inhibitors from fungal metabolites and explore its ...
Williams, Camille Cumming, Oliver Grignard, Lynn Rumedeka, Baron Bashige Saidi, Jaime Mufitini Grint, Daniel Drakeley, Chris Jeandron, Aurelie
Published in
BMC Infectious Diseases
BackgroundCholera remains a major global health challenge. Uvira, in the Democratic Republic of the Congo (DRC), has had endemic cholera since the 1970’s and has been implicated as a possible point of origin for national outbreaks. A previous study among this population, reported a case confirmation rate of 40% by rapid diagnostic test (RDT) among ...
Moise, Kenny Achille, Aude Mélody Batumbo, Doudou Bourdeau, Bertiny Rebaudet, Stanislas Lerebours, Gérald Henrys, Jean Hugues Raccurt, Christian
Published in
BMC Public Health
BackgroundReligious pilgrimages are among the anthropogenic factors known to be associated with the transmission of diarrheal diseases, such as cholera. This ecological study aimed to describe the evolution of cholera and assess the relationship between the implementation of the ‘coup de poing’ strategy during the patron saint festivities and the i...
Dorman, Matthew Domman, Daryl Poklepovich, Tomás Tolley, Charlotte Zolezzi, Gisella Kane, Leanne Viñas, María Rosa Panagópulo, Marcela Moroni, Miriam Binsztein, Norma
...
Biswas, Debashish Hossin, Raduan Rahman, Mahbubur Bardosh, Kevin Louis Watt, Melissa H Zion, Mazharul Islam Sujon, Hasnat Rashid, Md Mahbubur Salimuzzaman, M Flora, Meerjady S
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Published in
Social science & medicine (1982)
Diarrheal disease is one of the most common causes of hospital admission globally. The barriers that influence guideline-adherent care at resource limited hospitals are poorly defined, especially during diarrheal disease outbreaks. The objective of this study was to characterize challenges faced in diarrheal disease management in resource-limited h...
