Häcker, Georg
Published in
Frontiers in Cell and Developmental Biology
Chlamydiae are bacteria that are intriguing and important at the same time. The genus Chlamydia encompasses many species of obligate intracellular organisms: they can multiply only inside the cells of their host organism. Many, perhaps most animals have their own specifically adapted chlamydial species. In humans, the clinically most relevant speci...
Seth-Smith, Helena Bommana, Sankhya Dean, Deborah Read, Timothy Marti, Hanna
BACKGROUND: The obligate intracellular bacterial family Chlamydiaceae comprises a number of different species that cause disease in various vertebrate hosts including humans. Chlamydia suis, primarily found in the gastrointestinal tract of pigs, is the only species of the Chlamydiaceae family to have naturally gained tetracycline resistance (TetR),...
Scholz, Jana Holland, Gudrun Laue, Michael Banhart, Sebastian Heuer, Dagmar
Published in
mBio
Host cell egress is essential for intracellular pathogens to spread within an organism and for host-to-host transmission. Here, we characterize Chlamydia-containing sphere (CCS) formation as a novel and predominant non-lytic egress pathway of the intracellular pathogens Chlamydia psittaci and Chlamydia trachomatis. CCS formation is fundamentally di...
Price, Christopher T. D. Hanford, Hannah E. Al-Quadan, Tasneem Santic, Marina Shin, Cheon J. Da'as, Manal S. J. Abu Kwaik, Yousef
Published in
mBio
Grazing of amoebae on microorganisms represents one of the oldest predator-prey dynamic relationships in nature. It represents a genetic “melting pot” for an ancient and continuous multi-directional inter- and intra-kingdom horizontal gene transfer between amoebae and its preys, intracellular microbial residents, endosymbionts, and giant viruses, w...
Bonazzi, Matteo
Published in
Frontiers in Cellular and Infection Microbiology
Wang, Yuxuan Fondell, Joseph D. Zhong, Guangming Fan, Huizhou
Published in
Microbiology Spectrum
Diallo, Aissata Overman, Grace Sah, Prakash Liechti, George W.
Published in
Infection and Immunity
Toll-like receptor 9 (TLR9) is an innate immune receptor that localizes to endosomes in antigen presenting cells and recognizes single stranded unmethylated CpG sites on bacterial genomic DNA (gDNA). Previous bioinformatic studies have demonstrated that the genome of the human pathogen Chlamydia trachomatis contains TLR9 stimulatory motifs, and cor...
Chaiwattanarungruengpaisan, Somjit Thongdee, Metawee Arya, Nlin Paungpin, Weena Sirimanapong, Wanna Sariya, Ladawan
Published in
Acta tropica
Chlamydiosis, an infection caused by several Chlamydia species, has been reported in Nile, saltwater, and Siamese crocodiles. Despite its widespread reports in various countries, including Thailand, genetic information on Chlamydia species remains limited. This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlam...
Dockterman, Jacob Reitano, Jeffrey R. Everitt, Jeffrey I. Wallace, Graham D. Hendrix, Meghan Taylor, Gregory A. Coers, Jörn
Published in
mBio
In response to genital Chlamydia infection, the immune system mounts a proinflammatory response to resist the pathogen, yet inflammation must be tightly controlled to avoid collateral damage and scarring to host genital tissue. Variation in the human IRGM gene is associated with susceptibility to autoinflammatory diseases but its role in ameliorati...
Wurihan, Wurihan Wang, Yuxuan Yeung, Sydney Zou, Yi Lai, Zhao Fondell, Joseph Zhong, Guangming Fan, Huizhou Li, Wei Vivian
The obligate intracellular bacterium Chlamydia has a unique developmental cycle that alternates between two contrasting cell types. With a hardy envelope and highly condensed genome, the small elementary body (EB) maintains limited metabolic activities yet survives in extracellular environments and is infectious. After entering host cells, EBs diff...
