Li, Yin Wu, Lianyun Yong, Yanhong Niu, Xueting Gao, Yuan Zhou, Qiu Xie, Huili Liu, Xiaoxi Li, Youquan Yu, Zhichao
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Published in
Nutrition (Burbank, Los Angeles County, Calif.)
This study aimed to explore the protective mechanism of chitosan oligosaccharide (COS) against lipopolysaccharide (LPS)-induced inflammatory responses in IEC-6 cells and dextran sodium sulfate (DSS)-induced colitis in mice. The cell inflammation model was constructed by LPS in vitro and enteritis model by DSS in vivo. Following LPS exposure, IEC-6 ...
Li, Bing Han, Lingyu Ma, Jinlong Zhao, Meijuan Yang, Binghui Xu, Mei Gao, Yujia Xu, Qingsong Du, Yuguang
Published in
Carbohydrate polymers
Chitosan oligosaccharide (COS) is an important carbohydrate-based biomaterial for synthesizing candidate drugs and biological agents. This study synthesized COS derivatives by grafting acyl chlorides of different alkyl chain lengths (C8, C10, and C12) onto COS molecules and further investigated their physicochemical properties and antimicrobial act...
Manivasagan, Panchanathan Khan, Fazlurrahman Rajan Dhatchayeny, Durai Park, Sumin Joe, Ara Han, Hyo-Won Seo, Sun-Hwa Thambi, Thavasyappan Giang Phan, V H Kim, Young-Mog
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Published in
Journal of advanced research
Despite the many advanced strategies that are available, rapid gene mutation in multidrug-resistant bacterial infections remains a major challenge. Combining new therapeutic strategies such as chemo-photothermal therapy (PTT) with high antibacterial efficiency against drug-resistant Listeria monocytogenes (LM) is urgently needed. Here, we report sy...
Lan, Jinxin Chen, Jiazhen Zhu, Ruiqi Lin, Changmei Ma, Xiaojuan Cao, Shilin
Published in
International Journal of Biological Macromolecules
The worldwide outbreak of SARS-CoV-2 has attracted extensive attention to antibacterial and antivirus materials. Cellulose is the most potential candidate for the preparation of green, environmentally friendly antibacterial and antiviral materials. Herein, modified cellulosic fibers with sustained antibacterial and antiviral performance was prepare...
Jahan, Marefa Wilson, Cara McGrath, Shawn Francis, Nidhish Wynn, Peter C. Du, Yuguang Allworth, Bruce Wang, Bing
Chitosan oligosaccharide (COS) is a hydrolyzate of the structural polysaccharide, chitin, extracted from crab and shrimp shells, which has significant health benefits for humans including boosting immunity. However, there is limited information on the potential use of COS for sheep health and production. We supplemented COS via a loose lick to preg...
Jahan, Marefa Wilson, Cara McGrath, Shawn Francis, Nidhish Wynn, Peter C. Du, Yuguang Allworth, Bruce Wang, Bing
Chitosan oligosaccharide (COS) is a hydrolyzate of the structural polysaccharide, chitin, extracted from crab and shrimp shells, which has significant health benefits for humans including boosting immunity. However, there is limited information on the potential use of COS for sheep health and production. We supplemented COS via a loose lick to preg...
Li, Ruilian Zhu, Limeng Liu, Dongdong Wang, Wenjing Zhang, Chen Jiao, Siming Wei, Jinhua Ren, Lishi Zhang, Yuchen Gou, Xun
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The fungal cell wall is an ideal target for the design of antifungal drugs. In this study we used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains. Results showed that HCOS was successfully incorporated into the dynamic cell wall organi...
Li, Ruilian Zhu, Limeng Liu, Dongdong Wang, Wenjing Zhang, Chen Jiao, Siming Wei, Jinhua Ren, Lishi Zhang, Yuchen Gou, Xun
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The fungal cell wall is an ideal target for the design of antifungal drugs. In this study we used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains. Results showed that HCOS was successfully incorporated into the dynamic cell wall organi...
Qi, Xiaoyan Zhao, Yinglin Su, Haipeng Wang, Lele Li, Ling Ma, Rui Yan, Xiaochen Sun, Jianan Wang, Sai Mao, Xiangzhao
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Published in
Talanta
Herein, the split aptamers, chitosan oligosaccharide, and AuNPs were combined as nanocomposites that present different formations to develop a label-free colorimetric aptasensor for rapid detection of small molecules. Kanamycin was chosen as a model target. Computational studies were performed to assist in the design of orientated immobilization of...
Zeng, Xiaohu Zhu, Xin Tian, Qikang Tan, Xiaoke Sun, Ning Yan, Min Zhao, Junwei Wu, Xiangxiang Li, Ruiqin Zhang, Zhenqiang
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Published in
Drug Delivery
Celastrol is a promising antitumor drug candidate, but the poor water solubility and cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan oligosaccharide (CSO) conjugate (Cel-CSO) for drug delivery. Celastrol was conjugated to a CSO backbone via amide bond formation, which was verified by infrared spectrum ...
