Zhang, Fuxin Muhire, Jules Sun, Xiao Pei, Dong Huang, Xinyi
Published in
Journal of chromatography. A
In this work, two different multiple dual-mode (MDM) counter-current chromatography methods, conventional MDM and modified MDM elution modes, were compared for the chiral separation of the ketoconazole enantiomers. The biphasic solvent system which consisted of n-hexane: isobutyl acetate: 0.1 mol/L phosphate buffer (2:4:6, v/v) (pH = 8.5) was emplo...
Ma, Xiaofei Wang, Qin Cai, Liangliang Xiao, Mingbing
Published in
Analytical and bioanalytical chemistry
Recently, deep eutectic solvents (DESs) have attracted considerable interest in analytical chemistry. This work described the enantioseparations of twenty amino alcohol drugs with several DESs based on lactobionic acid (LA) as the sole chiral selector in capillary electrophoresis (CE) firstly. Compared to the single LA system and the ionic liquid/L...
Liu, Xin-Yi Tang, Hong-Xia Sheng, Wen-Bing Luo, Qu-Jing Mao, Lin-Xi Yang, Yu-Pei Guo, Xiao-Zhou Wu, Qing-Lai Jian, Yu-Qing Wang, Wei
...
Published in
BMC chemistry
Fraxinus hubeiensis is a plant endemic to China and widely used as folk medicine to treat various diseases. However, its chemical constituents have never been reported sufficiently. Thus, the primary objective of this study was to investigate the phytochemical constituents and biological activities of F. hubeiensis leaves. Hence, combined column ch...
Morvan, Marine
The analysis and characterization of aging and archaeological proteins are among the latest challenges in analytical chemistry. Different techniques have been developed to analyze recent proteins but have not been fully applied to aging proteins. This contributes to the lack of knowledge regarding the aging mechanism of proteins. In addition, the a...
Gao, Lidi Cui, Hongshou Guo, Xinyu Dong, Qing You, Xingyu Guo, Xinshu Qin, Shili Jia, Lihua
Published in
Mikrochimica acta
A zeolitic imidazolate framework (ZIF)-8-silica hybrid monolithic column was prepared by one-step sol-gel method. The stationary phase in the monolithic column was characterized by Fourier-transform infrared spectra, X-ray diffraction, thermogravimetric analysis, nitrogen adsorption/desorption, and zeta potential. The results showed that ZIF-8-sili...
Morvan, Marine Mikšík, Ivan
Collagen is the most abundant protein in the animal and human bodies, and it is not exempt from this aging phenomenon. Some age-related changes may appear on collagen sequences, such as increased surface hydrophobicity, the appearance of post-translational modifications, and amino acids racemization. This study has shown that the protein hydrolysis...
Li, Xinyu Ma, Qianjie Zheng, Xiangtai Chen, Qin Sun, Xiaodong
Published in
Journal of Pharmaceutical Analysis
• Recent advanced stationary phases for chiral separation in open tubular capillary electrochromatography. • Metal organic frameworks; covalent organic frameworks; nanoparticles; molecularly imprinted materials. • Capillary electrophoresis - mass spectrometry.
Rahmani, Turaj Ampe, Adriaan Lynen, Frederic
Chirality is a prevalent property found in nature, caused by the presence of a (carbon) chiral center in a molecule. Many molecules with different chirality greatly vary in their chemical properties, therefore the ability for separation and detection of these molecules is of utmost importance in the biomedical and pharmaceutical industries. (1) How...
Rahmani, Turaj Ampe, Adriaan Lynen, Frederic
Analyzing complex samples, especially those including stereoisomers, is a challenging and time-consuming process. Two-dimensional chromatography has emerged in recent years to minimize these complications by improving selectivity and peak capacity. In addition, the development of columns with small particles has accelerated the analysis time, allow...
Sun, Ying Jia, Pu Wei, Jingdong Bai, Yujun Yang, Lingjian Bai, Yajun Zheng, Xiaohui
Published in
Journal of pharmaceutical and biomedical analysis
The analysis and separation of chiral compounds with wide polar range by supercritical fluid chromatography is of major importance in the process of drug development and quality control. In this work, a fast and reliable enantioselective method for the simultaneous quantitative determination of 8 DBZ-related enantiomers has been successfully develo...
