Hou, Junyi Pan, Tao Li, Fangyuan Sang, Qingqing Wu, Xiongyan Li, Jianfang Yu, Beiqin Zang, Mingde Zhu, Zheng-Gang Su, Liping
...
Published in
Biochemical pharmacology
Cancer stem cells (CSCs) have been proposed to explain tumor relapse and chemoresistance in various types of cancers, and androgen receptor (AR) has been emerged as a potential regulator of stemness in cancers. However, the underlying mechanism of AR-regulated CSCs properties and chemoresistance in gastric cancer (GC) remains unknown. Here, we show...
Yang, Qi Sun, Yang Qiu, Bo Zhao, Huanhuan
Published in
International dental journal
About one-third of patients with oral squamous cell carcinoma (OSCC) have a risk of occurrence and chemoresistance, making survival rates abysmal. We aim to evaluate the role of F-box/WD repeat-containing protein 7 (FBXW7) to further develop efficient treatment of chemoresistant OSCC. FBXW7 overexpression was induced in human OSCC cell lines includ...
Sun, Mingchuang Li, Zhaoxing Wang, Xiaoyuan Zhao, Meirong Chu, Yuan Zhang, Zehua Fang, Kang Zhao, Ziying Feng, Anqi Leng, Zhuyun
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Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers because of its robust aggressive phenotype and chemoresistance. TAO kinase belongs to mitogen-activated protein kinases, which mediate drug resistance in multiple cancers. However, the role of TAO kinase in ESCC progression and chemoresistance has never been explored. Here, i...
Alkhathami, Ali G Sahib, Ameer S Al Fayi, Majed Saad Fadhil, Ali Abdulhussain Jawad, Mohammed Abed Shafik, Sahar Ahmad Sultan, Safwan Jassim Almulla, Abbas F Shen, Min
Published in
Environmental research
The metabolism of cancer has been an interesting hallmark and metabolic reprogramming, especially the change from oxidative phosphorylation in mitochondria to glucose metabolism known as glycolysis occurs in cancer. The molecular profile of glycolysis, related molecular pathways and enzymes involved in this mechanism such as hexokinase have been fu...
Hannon Barroeta, Patricia O'Sullivan, Maureen J Zisterer, Daniela M
Published in
Journal of cancer research and clinical oncology
Malignant rhabdoid tumour (MRT) is a rare and aggressive childhood malignancy that occurs in the kidneys or central nervous system and is associated with very poor prognosis. Chemoresistance is a major issue in the treatment of this malignancy leading to an urgent need for a greater understanding of its underlying mechanisms in MRT and novel treatm...
Zhang, Rui Zeng, Ying Deng, Jun-Li
Published in
Clinical and experimental medicine
Long non-coding RNAs play important roles in cellular functions and disease development. H19, as a long non-coding RNA, is pervasively over-expressed in almost all kinds of human malignant tumors. Although many studies have reported that H19 is closely associated with tumor cell proliferation, apoptosis, invasion, metastasis, and chemoresistance, t...
Hashemi, Mehrdad Taheriazam, Afshin Daneii, Pouria Hassanpour, Aria Kakavand, Amirabbas Rezaei, Shamin Hejazi, Elahe Sadat Aboutalebi, Maryam Gholamrezaie, Hamidreza Saebfar, Hamidreza
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Published in
Journal of cell communication and signaling
Urological cancers have obtained much attention in recent years due to their mortality and morbidity. The most common and malignant tumor of urological cancers is prostate cancer that imposes high socioeconomic costs on public life and androgen-deprivation therapy, surgery, and combination of chemotherapy and radiotherapy are employed in its treatm...
Tomizawa, Satoshi Takano, Shigetsugu Eto, Ryotaro Takayashiki, Tsukasa Kuboki, Satoshi Ohtsuka, Masayuki
Published in
Cancer cell international
Semaphorins, axon guidance cues in neuronal network formation, have been implicated in cancer progression. We previously identified semaphorin 3 C (SEMA3C) as a secreted protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). We, therefore, hypothesized that SEMA3C supports PDAC progression. In this study, we aimed to investigate the clin...
Chen, Si-Yu Cao, Jin-Long Li, Kun-Peng Wan, Shun Yang, Li
Published in
Journal of cancer research and clinical oncology
The bridging integrator 1 (BIN1) protein was originally identified as a pro-apoptotic tumor suppressor that binds to and inhibits oncogenic MYC transcription factors. BIN1 has complex physiological functions participating in endocytosis, membrane cycling, cytoskeletal regulation, DNA repair deficiency, cell-cycle arrest, and apoptosis. The expressi...
Wan, Jiangyang Feng, Ziyu Shi, Jianhua Li, Qiang
Published in
Asian journal of surgery
