Deng, Peng Sun, Ming Zhao, Wen-Yan Hou, Bin Li, Kai Zhang, Tao Gu, Feng
Published in
World Journal of Gastroenterology
BACKGROUND Gastric cancer (GC) is a prevalent malignancy, leading to a high incidence of cancer-associated death. Cisplatin (DDP)-based chemotherapy is the principal therapy for clinical GC treatment, but DDP resistance is a severe clinical challenge and the mechanism remains poorly understood. Circular RNAs (circRNAs) have been identified to play ...
Dong, Bing Li, Shiyu Zhu, Shuangli Yi, Ming Luo, Suxia Wu, Kongming
Published in
Experimental Hematology & Oncology
Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be...
Yu, Zhao-liang Chen, Yu-feng Zheng, Bin Cai, Ze-rong Zou, Yi-feng Ke, Jia Lan, Ping Gao, Feng Xiao-jian,
Published in
Cancer Cell International
BackgroundCancer stem cells (CSCs) are a small subpopulation of cells within tumors with stem cell property. Increased evidence suggest that CSCs could be responsible for chemoresistance and recurrence in colorectal cancer (CRC). However, a reliable therapeutic target on CSCs is still lacking.MethodsHere we describe a two-step strategy to generate ...
Shu, Hao Yuan, Bin Huang, Yao Wang, Lei He, Bing Sun, Qi Sun, Luning
Published in
Journal of Orthopaedic Surgery and Research
ObjectivesPrevious studies showed overexpression of ABCG2 in a variety of tumor tissues, which could potentially indicate the probability of chemotherapy resistance. This study aimed to reveal the role of ABCG2 in the development of chemotherapy resistance and the prognosis of osteosarcoma (OS).MethodsSixty-eight OS patients were included in this s...
Zhang, Ming Wang, Yan Jiang, Longyang Song, Xinyue Zheng, Ang Gao, Hua Wei, Minjie Zhao, Lin
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundAdriamycin (ADR) resistance is one of the main obstacles to improving the clinical prognosis of breast cancer patients. Long noncoding RNAs (lncRNAs) can regulate cell behavior, but the role of these RNAs in the anti-ADR activity of breast cancer remains unclear. Here, we aim to investigate the imbalance of a particular long noncoding RNA...
Kita, Diogo Henrique Guragossian, Nathalie Zattoni, Ingrid Fatima Moure, Vivian Rotuno Rego, Fabiane Gomes de Moraes Lusvarghi, Sabrina Moulenat, Thomas Belhani, Billel Picheth, Geraldo Bouacida, Sofiane
...
Published in
Scientific Reports
The ATP-binding cassette transporter ABCG2 mediates the efflux of several chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in many cancers. The most promising strategy to overcome ABCG2-mediated MDR is the use of specific inhibitors. Despite many efforts, the identification of new potent and specific ABCG2 inhib...
Levi, Michela Salaroli, Roberta Parenti, Federico De Maria, Raffaella Zannoni, Augusta Bernardini, Chiara Gola, Cecilia Brocco, Antonio Marangio, Asia Benazzi, Cinzia
...
Published in
BMC Veterinary Research
BackgroundDoxorubicin (DOX) is widely used in both human and veterinary oncology although the onset of multidrug resistance (MDR) in neoplastic cells often leads to chemotherapy failure. Better understanding of the cellular mechanisms that circumvent chemotherapy efficacy is paramount. The aim of this study was to investigate the response of two ca...
Susana, Fuentes-Vélez Sharmila, Fagoonee Alessandro, Sanginario Valentina, Gallo Chiara, Riganti Marco, Pizzi Fiorella, Altruda Danilo, Demarchi
Published in
Talanta
Interest in impedance-based cellular assays is rising due to their remarkable advantages, including label-free, low cost, non-invasive, non-destructive, quantitative and real-time monitoring. In order to test their potential in cancer treatment decision and early detection of chemoresistance, we devised a new custom-made impedance measuring system ...
Zhang, Zhi-Hui Hong, Qian Zhang, Zhi-Cheng Xing, Wei-Yang Xu, Shen Tian, Qi-Xing Ye, Qing-Lin Wang, Hua Yu, De-Xin Xie, Dong-Dong
...
Published in
Ecotoxicology and environmental safety
Several epidemiological studies reported that chronic arsenic exposure increased risk of prostate cancer. This study aimed to investigate whether chronic NaAsO2 exposure elevates stemness and chemoresistance in prostate cancer cells. DU145 (wild-type p53) and PC-3 (p53-null) cells were exposed to NaAsO2 (2 μmol/L) for 30 generations. IC50s to docet...
Oo, Khine Kyaw Kamolhan, Thanpawee Soni, Anish Thongchot, Suyanee Mitrpant, Chalermchai O-charoenrat, Pornchai Thuwajit, Chanitra Thuwajit, Peti
Published in
BMC Cancer
BackgroundChemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of this study was to develop an an...
