JALALPOUR, Shila MIRZAEE, Vahid TAHERI, Mohammad FATHOLLAHI, Mahmood Sheikh KHORRAMDELAZADEH, Hossain JAFARZADEH, Abdollah
ABSTRACT BACKGROUND: During the Helicobacter pylori (HP) infection, the infiltration of the leukocytes into stomach mucosa is directed by locally produced chemokines that play a decisive role in infection outcome. The CagA is the most potent virulence factor of HP, so that the infection with CagA + strains is associated with more severe complicatio...
Mirza, Muhammad Usman; 112202; Saadabadi, Atefeh; Vanmeert, Michiel; 94348; Salo-Ahen, Outi MH; Abdullah, Iskandar; Claes, Sandra; De Jonghe, Steven; 40092; Schols, Dominique; 9441; Ahmad, Sarfraz; Froeyen, Matheus; 3056;
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Chemokine receptors are key regulators of cell migration in terms of immunity and inflammation. Among these, CCR5 and CXCR4 play pivotal roles in cancer metastasis and HIV-1 transmission and infection. They act as essential co-receptors for HIV and furnish a route to the cell entry. In particular, inhibition of either CCR5 or CXCR4 leads very often...
Subramanian, Narayani Ramanathan, Srishti Paul, Solomon Franklin Durairaj Venkatesan, Vettriselvi Koshy, Teena
Published in
Neuroscience letters
Recent studies have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. Also, numerous lines of evidence have indicated that inflammatory processes are involved in the pathogenesis of Parkinson's disease (PD). We have examined whether single nucleotide polymorphisms at the genes encoding chemokines RANT...
Yeregui, Elena Viladés, Consuelo Domingo, Pere Ceausu, Andra Pacheco, Yolanda María Veloso, Sergi Inciarte, Alexy Vidal-González, Judit Peraire, Maria Perpiñán, Carles
...
Published in
EBioMedicine
The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+T-cell turnover. We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, M...
Yang, Jiaqi Sontag, David Gong, Yuewen Minuk, Gerald Y
Published in
Annals of hepatology
Intrahepatic (I-CCA) and extrahepatic (E-CCA) cholangiocarcinoma (CCA) have different growth patterns and risks for tumor metastasis. Inhibition and/or activation of the chemokine receptor CCR subclasses have been reported to alter tumor cell biology in non-CCA cancers. In this study we documented CCR expression profiles in representative human I-C...
Mirza, Muhammad Usman Saadabadi, Atefeh Vanmeert, Michiel Salo-Ahen, Outi M H Abdullah, Iskandar Claes, Sandra De Jonghe, Steven Schols, Dominique Ahmad, Sarfraz Froeyen, Matheus
...
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Chemokine receptors are key regulators of cell migration in terms of immunity and inflammation. Among these, CCR5 and CXCR4 play pivotal roles in cancer metastasis and HIV-1 transmission and infection. They act as essential co-receptors for HIV and furnish a route to the cell entry. In particular, inhibition of either CCR5 or CXCR4 leads very often...
Alassaf, Enana Mueller, Anja
Published in
European journal of pharmacology
Migration of tumour cells is a fundamental process for the formation and progression of metastasis in malignant diseases. Chemokines binding to their cognate receptors induce the migration of cancer cells, however, the molecular signalling pathways involved in this process are not fully understood. Protein kinase C (PKC) has been shown to regulate ...
Wang, Xiaoqian Chen, Weikang Yuan, Yan
Published in
Virology
Kaposi's sarcoma (KS) tends to occur in injured or inflamed sites of the body, which is described as the "Koebner phenomenon". KS is also unique in its extraordinary angio-hyperplastic inflammatory phenotype. Recently, evidence has accrued indicating that KS may derive from KSHV-infected mesenchymal stem cells (MSCs), which possess enhanced migrati...
D'Agostino, Gianluca García-Cuesta, Eva M Gomariz, Rosa P Rodríguez-Frade, José Miguel Mellado, Mario
Published in
Biochemical and biophysical research communications
The chemokines receptor family are membrane-expressed class A-specific seven-transmembrane receptors linked to G proteins. Through interaction with the corresponding ligands, the chemokines, they induce a wide variety of cellular responses including cell polarization, movement, immune and inflammatory responses, as well as the prevention of HIV-1 i...
Zheng, Yingying Corrêa-Silva, Simone de Souza, Eloisa Corrêa Maria Rodrigues, Regina da Fonseca, Fernanda A Macaferri Gilio, Alfredo Elias Carneiro-Sampaio, Magda Palmeira, Patricia
Published in
Cytokine
Studies have shown that immune components of human milk can be changed during an infection in the nursing infant. Macrophages are abundant in human milk and they are classified into inflammatory (CD16-) and noninflammatory (CD16+) subsets. This study investigated CD16+ and CD16- macrophage homing into breast milk in response to ongoing infections i...