Published in DNA repair
TOPBP1 is an important scaffold protein that helps orchestrate the cellular response to DNA damage. Although it has been previously appreciated that TOPBP1 can form oligomers, how this occurs and the functional consequences for oligomerization were not yet known. Here, we use protein binding assays and other biochemical techniques to study how TOPB...
Published in World Journal of Clinical Oncology
A major advance was made to reduce the side effects of cancer therapy via the elucidation of the tumor-specific lytic path “hyperploid progression-mediated death” targeting retinoblastoma (Rb) or p53 -mutants defective in G1 DNA damage checkpoint. The genetic basis of human cancers was uncovered through the cloning of the tumor suppressor Rb gene. ...
This work provides an optimal checkpointing strategy to protect iterative applications from fail-stop errors. We consider a very general framework, where the application repeats the same execution pattern by executing consecutive iterations, and where each iteration is composed of several tasks. These tasks have different execution lengths and diff...
This thesis focuses on a major problem for the HPC community: resilience. Computing platforms are bigger and bigger in order to reach what we call exascale, i.e. a computing capacity of 10^18 FLOP/s but they suffer numerous failures. Reducing the execution time and handling the errors are two linked problems: for instance, replication (computing re...
Published in Hematology/oncology and stem cell therapy
Checkpoint inhibitors, cancer immunotherapies, are the new forms of treatment for gray zone lymphoma, a rare subtype that combines the characteristics of both Hodgkin and non-Hodgkin disease forms. Programmed cell death protein 1/programmed cell death ligand 1 (PD-L1/PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) modulate the immune...
Published in Cell Communication and Signaling
Cancer displays high levels of heterogeneity and mutation potential, and curing cancer remains a challenge that clinicians and researchers are eager to overcome. In recent years, the emergence of cancer immunotherapy has brought hope to many patients with cancer. Cancer immunotherapy reactivates the immune function of immune cells by blocking immun...
Published in Pediatric neurology
Treatment for brain tumors has recently shifted to using the power of the immune system to destroy cancer cells with promising results. Many immunotherapeutic approaches that have been used in adults, including checkpoint inhibitors, vaccine therapy, adoptive immunotherapy, such as chimeric antigen receptor T cell therapy, and viral therapy, are no...
Published in Protein expression and purification
Antibodies that block interaction of immune checkpoint receptors with its ligands have revolutionized the treatment of several cancers. Despite the success of this approach, the high cost has been restricted the use of this class of drugs. In this context, the development of biosimilar can be an important strategy for reducing prices and expanding ...
Published in Computational Science – ICCS 2020
Nowadays, checkpoints have gained some relevance, given the increasing complexity of scientific applications for the use of many resources over a long period of time. Thus, in fault tolerance strategies, in addition to taking into account the impact that the application itself has on HPC systems, we must add the impact of the checkpoint. The checkp...
Published in World Journal of Gastroenterology
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summa...
