Quintero, Wendy Lorena Moreno, Erika Marcela Pinto, Sandra Milena Leal Sanabria, Sandra Milena Stashenko, Elena García, Liliana Torcoroma
Published in
BMC Complementary Medicine and Therapies
BackgroundParasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Nevertheless, there are no efficient therapies to resolve the Trypanosoma cruzi infection and prevent the disease progression. Intere...
Ferragut, Fátima Acevedo, Gonzalo R. Gómez, Karina A.
Published in
Frontiers in Immunology
The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas disease, are relevant for both parasite control and disease pathogenesis. Several studies have been focused on their phenotype and functionally, but only a few have drilled down to identify the parasite proteins that are processed and presented to these cells, es...
Martínez-Peinado, Nieves Cortes-Serra, Nuria Tallini, Luciana R. Pinazo, Maria-Jesus Gascon, Joaquim Bastida, Jaume Alonso-Padilla, Julio
Published in
Parasites & Vectors
BackgroundChagas disease is a neglected zoonosis caused by the parasite Trypanosoma cruzi. It affects over six million people, mostly in Latin America. Drugs available to treat T. cruzi infection have associated toxicity and questionable efficacy at the chronic stage. Hence, the discovery of more effective and safer drugs is an unmet medical need. ...
Mohareb, Amir M. Rosenberg, Jacob M. Bhattacharyya, Roby P. Kotton, Camille N. Chu, Jacqueline T. Jilg, Nikolaus Hysell, Kristen M. Albin, John S. Sen, Pritha Bloom, Seth M.
...
Published in
Journal of Immigrant and Minority Health
Immunomodulating therapies for COVID-19 may carry risks of reactivating latent infections in foreign-born people. We conducted a rapid review of infection-related complications of immunomodulatory therapies for COVID-19. We convened a committee of specialists to formulate a screening and management strategy for latent infections in our setting. Dex...
Bianchi, Tanise Freitas Jeske, Sabrina Grala, Ana Paula da Paz de Leon, Italo Ferreira Bedin, Cleonara de Mello, Fernanda da Silva, Guilherme Carlos Castilhos Villela, Marcos Marreiro
Published in
Revista do Instituto de Medicina Tropical de São Paulo
Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3rd Regional Health Coordinati...
Baldoni, Nayara Ragi Quintino, Nayara Dornela Alves, Geisa Cristina Silva Oliveira, Claudia Di Lorenzo Sabino, Ester Cerdeira Ribeiro, Antonio Luiz Pinho Cardoso, Clareci Silva
Published in
Revista do Instituto de Medicina Tropical de São Paulo
Chagas disease (CD) is a neglected tropical highly morbid disease that can have a negative impact on the quality of life (QoL). The purpose of this study was to conduct an integrative review to analyze the QoL of patients with CD in the chronic phase of the disease, as well as the instruments used and the effect of different interventions. The revi...
Libisch, María Gabriela Rego, Natalia Robello, Carlos
Published in
Frontiers in Cellular and Infection Microbiology
Chagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight million people in the world. T. cruzi is a complex taxon represented by different strains with particular characteristics, and it has the ability to infect and interact with almost any nucleated cell. The T. cruzi-host cell interactions will trigger molecular s...
Borella Marfil Anhê, Ana Carolina Maia Godoy, Raquel Soares Nacif-Pimenta, Rafael Barbosa, Wagner Faria Lacerda, Marcus Vinicius Monteiro, Wuelton Marcelo Costa Secundino, Nágila Francinete Paolucci Pimenta, Paulo Filemon
Published in
Open Biology
Rhodnius prolixus is the principal vector of Trypanosoma cruzi , the aetiological agent of Chagas disease in American countries. This insect is haematophagous during all life cycles and, to antagonize its haemostatic, inflammatory and immune systems, it secretes saliva while feeding on the vertebrate host's blood. Here, we investigated characterist...
Gonçalves, Raquel Logan, Rhiannon A. E. Ismail, Hanafy M. Paine, Mark J. I. Bern, Caryn Courtenay, Orin
Published in
Parasites & Vectors
BackgroundIndoor residual spraying (IRS) of insecticides is a key method to reduce vector transmission of Trypanosoma cruzi, causing Chagas disease in a large part of South America. However, the successes of IRS in the Gran Chaco region straddling Bolivia, Argentina, and Paraguay, have not equalled those in other Southern Cone countries.AimsThis st...
Wan, Xianxiu Garg, Nisha Jain
Published in
Frontiers in Cellular and Infection Microbiology
Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated cytotoxic proinflammatory reactions and cellular injuries, which are the common source of reactive oxygen species (ROS) and reactive nitrogen species (RNS) during the acute...
