Fares, Mazigh Cochet-Bernoin, Marielle Gonzalez, Gaëlle Montero-Menei, Claudia N. Blanchet, Odile Benchoua, Alexandra Boissart, Claire Lecollinet, Sylvie Richardson, Jennifer Haddad, Nadia
...
Published in
Journal of Neuroinflammation
BackgroundTick-borne encephalitis virus (TBEV) is a member of the Flaviviridae family, Flavivirus genus, which includes several important human pathogens. It is responsible for neurological symptoms that may cause permanent disability or death, and, from a medical point of view, is the major arbovirus in Central/Northern Europe and North-Eastern As...
Goodwin, Marshall S. Croft, Cara L. Futch, Hunter S. Ryu, Daniel Ceballos-Diaz, Carolina Liu, Xuefei Paterno, Giavanna Mejia, Catalina Deng, Doris Menezes, Kimberly
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Published in
Molecular Neurodegeneration
BackgroundRecombinant adeno-associated virus (rAAV) is widely used in the neuroscience field to manipulate gene expression in the nervous system. However, a limitation to the use of rAAV vectors is the time and expense needed to produce them. To overcome this limitation, we evaluated whether unpurified rAAV vectors secreted into the media following...
Wilson, Tais M Sousa, Susy K H Paludo, Giane R de Melo, Cristiano B Llano, Horwald A B Soares, Rodrigo M Castro, Marcio B
Published in
Parasitology international
Sarcocistys -associated menigoencephalitis is virtually an unrecognized cause of neurological disease in chickens. An undescribed species of Sarcocystis cause fatal infection in two backyard chickens in the Midwest of Brazil. Infected chickens presented anorexia, weight loss, incoordination, ataxia and opisthotonos. Yellow necrotic foci in the gray...
Sriramula, Srinivas
Published in
Pharmacological research
Kinins are a family of oligopeptides of the kallikrein-kinin system that act as potent vasoactive hormones and inflammatory mediators. The bioactive kinins mainly consist of bradykinin and kallidin, and their metabolites des-Arg9-bradykinin and des-Arg10-kallidin. Physiological effects of kinins are mediated by activation of highly selective G-prot...
Castilla-Cortázar, Inma Aguirre, Gabriel A. Femat-Roldán, Giovana Martín-Estal, Irene Espinosa, Luis
Published in
Journal of Translational Medicine
Parkinson’s disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output neurons, leading to a movement disorder most commonly characterized by akinesia or bradykinesia, rigidity and tremor. Also, PD is less fre...
Ma, Xiu-Jian Li, Da Wang, Liang Hao, Shu-Yu Zhang, Li-Wei Zhang, Jun-Ting Wu, Zhen
Published in
Neurosurgical review
No standard treatment protocol to guide the management of the primary central nervous system atypical teratoid rhabdoid tumors (ATRTs). To evaluate the efficacy of GTR (gross total resection), RT (radiotherapy), CCMT (conventional chemotherapy), or intensified chemotherapy (ICMT) and verify the optimal treatment strategy. A total of 501 cases (18 c...
Quiñonez-Silvero, Claudia Hübner, Kathleen Herzog, Wiebke
Published in
Developmental biology
To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentia...
Britzolaki, Aikaterini Saurine, Joseph Klocke, Benjamin Pitychoutis, Pothitos M
Published in
Advances in experimental medicine and biology
Calcium (Ca2+) is a fundamental regulator of cell fate and intracellular Ca2+ homeostasis is crucial for proper function of the nerve cells. Given the complexity of neurons, a constellation of mechanisms finely tunes the intracellular Ca2+ signaling. We are focusing on the sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) pump, an i...
Venugopal, Indu Mehta, Ankit I Linninger, Andreas A
Published in
Methods in molecular biology (Clifton, N.J.)
Nanoparticles offer several applications in the field of medicine such as targeted drug delivery, controlled drug release, and imaging applications. The central nervous system (CNS), in particular, has remained a challenge for drug delivery. This is mainly due to barriers such as the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (...
AlQazlan, Salman Albakr, Abdulrahman Al Towim, Abdullah Alsaadan, Yazeed Hassan, Hamdy Aljerian, Khaldoon Elwatidy, Sherif
Published in
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Juvenile xanthogranuloma (JXG) with the central nervous system (CNS) involvement is a rare disease entity that remains poorly understood, especially when the condition develops following treatment for Langerhans cell histiocytosis (LCH). A 21-year-old man who was diagnosed with LCH at age 2, several years following which he developed signs and symp...
