SARS-CoV-2: a new virus but a familiar inflammation brain pattern
Published in Brain, Behavior, and Immunity
Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (C...
Published in The American Journal of Case Reports
Patient: Female, 29-year-old Final Diagnosis: Refractory Hodgkin lymphoma with CNS involvement Symptoms: Blurred vision Medication: — Clinical Procedure: — Specialty: Hematology Objective: Rare disease Background: CNS involvement in Hodgkin lymphoma is rare. Despite various treatment options, median overall survival is only 13 months after diagnosi...
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.
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Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of CSF leukocytes. Multiple sclerosis (MS) - an autoi...
CHRONIC RESPONSES OF PHYSICAL AND IMAGERY TRAINING ON PARKINSON’S DISEASE
ABSTRACT Introduction Physical and motor imagery training is known to induce positive results in the quality of life of patients with neurodegenerative diseases. However, it is not known which effects are achievable when both types of training are combined. Objective This study aimed to investigate the effects of a combination of physical and image...
Simulating calcium signaling in fine astrocytic processes
Astrocytes are predominant glial cells in the central nervous system, which are essential for the formation of synapses, participate to the blood-brain barrier and maintain the metabolic, ionic and neurotransmitter homeostasis. Recently, astrocytes have emerged as key elements of information processing in the central nervous system. Astrocytes can ...
The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remy...
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The microbiota is now recognised as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress towards therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination, as occurs in multiple sclerosis. However, remyelination – the regeneration of myelin sheaths...
Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous sys...
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Approximately 15-40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS metastases, owing to the low levels of the drug reaching the tumour site. Here, we show that the enc...
Use of Central Nervous System (CNS) Medicines in Aged Care Homes: A Systematic Review and Meta-Analysis
Published in Journal of Clinical Medicine
Background: Both old age and institutionalization in aged care homes come with a significant risk of developing several long-term mental and neurological disorders, but there has been no definitive meta-analysis of data from studies to determine the pooled estimate of central nervous system (CNS) medicines use in aged care homes. We conducted this ...
Fibromyalgia and its New Lessons for Neuropsychiatry
Published in Medical Science Monitor Basic Research
Background Fibromyalgia (FM) is a centralized pain state that until recently has been shrouded in mystery and questionable as a disease entity in the eyes of many physicians, who considered it purely psychogenic. Fibromyalgia is now thought of as a discrete diagnosis with a clustering of symptoms characterized by central nervous system pain amplifi...
Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
It is now well-established that the macrophage and microglial response to CNS demyelination influences remyelination by removing myelin debris and secreting a variety of signaling molecules that influence the behaviour of oligodendrocyte progenitor cells (OPCs). Previous studies have shown that changes in microglia contribute to the age-related dec...
