Li, Yaqun Kang, Dong Ho Kim, Woong Mo Lee, Hyung Gon Kim, Seung Hoon You, Hyun Eung Choi, Jeong Il Yoon, Myung Ha
Published in
The Korean Journal of Pain
Background Supraspinal delivery of neurotensin (NTS), which may contribute to the effect of a systemically administered agonist, has been reported to be either pronociceptive or antinociceptive. Here, we evaluated the effects of systemically administered NTSR1 agonist in a rat model of neuropathic pain and elucidated the underlying supraspinal mech...
Fransen, Marc; 2737; Revenco, Iulia; 127673; Li, Hongli; Figueiredo Costa, Cláudio; 131598; Lismont, Celien; Van Veldhoven, Paul P;
Peroxisomes are multifunctional organelles best known for their role in cellular lipid and hydrogen peroxide metabolism. In this chapter, we review and discuss the diverse functions of this organelle in brain physiology and neurodegeneration, with a particular focus on oxida-tive stress. We first briefly summarize what is known about the vari-ous n...
de Almeida, Sergio Monteiro Kussen, Gislene Maria Botão Cogo, Laura Carvalho, José Henrique Nogueira, Keite
ABSTRACT Background: The timely diagnosis of tuberculous meningitis (TBM) is challenging. Molecular diagnostic tools are necessary for TBM, particularly in low- and middle-income countries. Objectives: We aimed to calculate the diagnostics characteristics of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in the cerebrospinal fluid (C...
Eme-Scolan, Elisa Dando, Samantha
Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease. This mini-review provides an overview of the current tools and approaches for studying microglia in vivo. We focus on tools for labeling microglia, highlighting the advantages and limitat...
de Miranda Henriques-Souza, Adélia Maria... de Melo, Ana Cláudia Marques Gouveia de Aguiar Coelho Silva Madeiro, Bianca Freitas, Leonardo Furtado Sampaio Rocha-Filho, Pedro Augusto Gonçalves, Fabrício Guimarães
Published in
Neuroradiology
The authors present a case of acute disseminated encephalomyelitis in a COVID-19 pediatric patient with positive SARS-CoV2 markers from a nasopharyngeal swab. A previously healthy 12-year-old-girl presented with a skin rash, headache, and fever. Five days after that, she had an acute, progressive, bilateral, and symmetrical motor weakness. She evol...
Petrova, Veselina Pearson, Craig S Ching, Jared Tribble, James R Solano, Andrea G Yang, Yunfei Love, Fiona Watt, Robert J Osborne, Andrew Reid, Evan
...
Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We achieved this by expressing the adaptor molecule Protrudin which is normally found at low levels in no...
Bin Salman, Ahmed A. Zaidi, Abdul Rehman Zia Altaf, Syed Yasir AlShehry, Nawal F. Tailor, Imran K. Motabi, Ibraheem H. Zaidi, Syed Ziauddin A.
Published in
The American Journal of Case Reports
Patient: Female, 57-year-old Final Diagnosis: CML accelerated phase with two isolated CNS blast crisis Symptoms: Headache Medication:— Clinical Procedure: — Specialty: Hematology Objective: Unusual clinical course Background: Chronic myeloid leukemia (CML) is usually a tri-phasic myeloproliferative neoplasm, characterized by the presence of the BCR...
Nouri-Vaskeh, Masoud Sharifi, Ali Khalili, Neda Zand, Ramin Sharifi, Akbar
Published in
Clinical Neurology and Neurosurgery
SARS-CoV-2 mainly invades respiratory epithelial cells by adhesion to angiotensin-converting enzyme 2 (ACE-2) and thus, infected patients may develop mild to severe inflammatory responses and acute lung injury. Afferent impulses that result from the stimulation of pulmonary mechano-chemoreceptors, peripheral and central chemoreceptors by inflammato...
Ramesh, Akshaya Schubert, Ryan D Greenfield, Ariele L Dandekar, Ravi Loudermilk, Rita Sabatino, Joseph J Koelzer, Matthew T Tran, Edwina B Koshal, Kanishka Kim, Kicheol
...
Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T cells, producers of pathogenic antibodies, and reservoirs for viruses that trigger demyelination. To interrogate these roles, single-cell RNA sequencing (scRNA-Seq) was perfor...
Walter, Brian Tamton, Hyder Lalama, Hector Cueva, Wilson
Published in
Journal Of Neuropsychiatry And Neurodisorders
INTRODUCTION Singultus, also known as hiccup, is a natural, involuntary process in which inhalation of breath triggers spasm of the diaphragm and intercostal muscles that is followed by rapid glottis closure [1]. Singultus is generally a benign, transient self-limited condition. Prolonged singultus can have debilitating effects on quality of life a...
