Jie, Lishi Zhang, Chaofeng Liu, Yujiang Huang, Zeling Xu, Bo Zhu, Zaishi Li, Yuwei Wang, Peimin Shi, Xiaoqing
Published in
Journal of ethnopharmacology
Quzhi Tang (QZT) is a compound formula consisting of six traditional Chinese medicinal herbs. It has achieved good clinical results in the treatment of knee osteoarthritis (KOA), and the potential drug mechanisms involved are worth exploring in depth. Using single-cell transcriptome analysis, this study identified the key target of senescence, GPNM...
Bang, Sooyoon Kim, Dong-Eun Kang, Hee-Taik Lee, Jong Hun
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sarcopenia, which refers to age-related muscle loss, presents a significant challenge for the aging population. Age-related changes that contribute to sarcopenia include cellular senescence, decreased muscle stem cell number and regenerative capacity, impaired autophagy, and mitochondrial dysfunction. Metformin, an anti-diabetic agent, activates AM...
Neri, Francesco Takajjart, Selma N Lerner, Chad A Desprez, Pierre-Yves Schilling, Birgit Campisi, Judith Gerencser, Akos A
Published in
GeroScience
Cellular senescence is a major driver of aging and age-related diseases. Quantification of senescent cells remains challenging due to the lack of senescence-specific markers and generalist, unbiased methodology. Here, we describe the Fully-Automated Senescence Test (FAST), an image-based method for the high-throughput, single-cell assessment of sen...
Dong, Zening Luo, Yahan Yuan, Zhangchen Tian, Yu Jin, Tianqiang Xu, Feng
Published in
Molecular cancer
Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and proliferation leading to the degeneration of cellular structure and function, has been implicated in various key physiological and pathological processes, particularly in cancer. Initially, CS was recognized as a barrier to tumorigenesis, serving as an intrinsic def...
Wu, Wenjuan Wu, Xinhui Qiu, Lingxiao Wan, Ruijie Zhu, Xiaoming Chen, Song Yang, Xinying Liu, Xueya Wu, Jizhen
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Pulmonary fibrosis is a chronic and progressive lung disease with high mortality. This study aims to explore the protective mechanism of quercetin against pulmonary fibrosis regarding cell senescence and gut microbiota. Rats were intratracheally injected with bleomycin (BLM) to establish a pulmonary fibrosis rat model. RLE-6TN cells were stimulated...
Baker, Andrew G Hartono, Muhamad Ou, Hui-Ling Popov, Andrea Bistrović Brown, Emma L Joseph, James Golinska, Monika González-Gualda, Estela Macias, David Ge, Jianfeng
...
Published in
Angewandte Chemie (International ed. in English)
There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of sene...
Czarnecka-Herok, Joanna Zhu, Kexin Flaman, Jean-Michel Goehrig, Delphine Vernier, Mathieu Makulyte, Gabriela Lamboux, Aline Dragic, Helena Rhinn, Muriel Médard, Jean-Jacques
...
The ELN gene encodes tropoelastin which is used to generate elastic fibers that insure proper tissue elasticity. Decreased amounts of elastic fibers and/or accumulation of bioactive products of their cleavage, named elastokines, are thought to contribute to aging. Cellular senescence, characterized by a stable proliferation arrest and by the senesc...
Cheng, Xiao Ali, Mohamed Sham Shihabudeen Haider Baki, Vijaya Bhaskar Moran, Matthew Su, Huabo Sun, Xinghui
Background and aims: Long noncoding RNAs are involved in the pathogenesis of atherosclerosis. As long non-coding RNAs maternally expressed gene 3 (Meg3) prevents cellular senescence of hepatic vascular endothelium and obesity-induced insulin resistance, we decided to examine its role in cellular senescence and atherosclerosis. Methods and Results: ...
Jia, Shicheng Liang, Rongji Chen, Jiayou Liao, Shuai Lin, Jianjing Li, Wei
Published in
Cellular & Molecular Biology Letters
Osteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations, and subsequent cartilage defects, OA eventually leads to a series of adverse outcomes such as ...
Cheng, Xiao Shihabudeen Haider Ali, Mohamed Sham Baki, Vijaya Bhaskar Moran, Matthew Su, Huabo Sun, Xinghui
Published in
Atherosclerosis
Long noncoding RNAs are involved in the pathogenesis of atherosclerosis. As long noncoding RNAs maternally expressed gene 3 (Meg3) prevents cellular senescence of hepatic vascular endothelium and obesity-induced insulin resistance, we decided to examine its role in cellular senescence and atherosclerosis. By analyzing our data and human and mouse d...
