Lagoumtzi, Sofia M Chondrogianni, Niki
Published in
Free radical biology & medicine
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases. Senescent cells (SC) exhibit a specific senescence-associated secretory phenotype (SASP), mainly ...
Wang, Wen-Juan Chen, Xiang-Mei Cai, Guang-Yan
Published in
Experimental gerontology
Renal fibrosis plays a crucial role in the progression of chronic kidney disease and end-stage renal disease. However, because the aetiology of this pathological process is complex and remains unclear, there is still no effective treatment. Cellular senescence and the senescence-associated secretory phenotype (SASP) have been reported to lead to re...
Tan, Yi-Zhou Xu, Xin-Yue Dai, Ji-Min Yin, Yuan He, Xiao-Tao Zhang, Yi-Lin Zhu, Tian-Xiao An, Ying Tian, Bei-Min Chen, Fa-Ming
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Published in
Stem Cell Research & Therapy
BackgroundStem cells that have undergone long-term ex vivo expansion are most likely functionally compromised (namely cellular senescence) in terms of their stem cell properties and therapeutic potential. Due to its ability to attenuate cellular senescence, melatonin (MLT) has been proposed as an adjuvant in long-term cell expansion protocols, but ...
DePianto, Daryle J Heiden, Jason A Vander Morshead, Katrina B Sun, Kai-Hui Modrusan, Zora Teng, Grace Wolters, Paul J Arron, Joseph R
Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers of senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity of these senescent cells remain unclear, and tools to characterize context-specific cellular senescence i...
Tesei, Anna Arienti, Chiara Bossi, Gianluca Santi, Spartaco De Santis, Ilaria Bevilacqua, Alessandro Zanoni, Michele Pignatta, Sara Cortesi, Michela Zamagni, Alice
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Published in
Journal of Experimental & Clinical Cancer Research
BackgroundRecent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with metastasis. Several groups including ours, reported the involvem...
Frasca, Daniela Saada, Yara Bou Garcia, Denisse Friguet, Bertrand
Published in
Mechanisms of ageing and development
Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend fr...
Klaus, Richard Niyazi, Maximilian Lange-Sperandio, Bärbel
Published in
Radiation Oncology
Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation therapy is limited by normal-tissue damage including kidney toxicity. Different thresholds for kidney toxicity exist for different entities of RT. Histopathologic...
Lee, Keng Siang Lin, Shuxiao Copland, David A. Dick, Andrew D. Liu, Jian
Published in
Journal of Neuroinflammation
Age-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking. Besides the association of innate immune p...
Cheng, Xiao Shihabudeen Haider Ali, Mohamed Sham Moran, Matthew Viana, Martonio Ponte Schlichte, Sarah L. Zimmerman, Matthew C. Khalimonchuk, Oleh Feinberg, Mark W. Sun, Xinghui
Published in
Redox Biology
•LncRNA Meg3 is a top differentially expressed lncRNA in the vascular endothelium in obese mice. •Meg3 knockdown causes cellular senescence of HUVECs and of hepatic endothelium in obese mice. •Meg3 expression is elevated in human NAFLD and NASH Nlivers, and correlates with CDKN2A expression -a senescent marker. •Meg3 knockdown impairs glucose homeo...
Chen, Zhuoying Xiong, Zhi-Fan Liu, Xiangjie
Published in
Experimental gerontology
Considerable researches implicate that the circadian clock regulates the responsive rhythms of organs and sets the orderly aging process of cells indirectly. It influences an array of diverse biological process including intestinal flora, peripheral inflammatory responses, and redox homeostasis. People with sleep disoders and other kinds of circadi...
