Wang, Hongzhen Liu, Xin Li, Guiying
Published in
Cell & Bioscience
There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important r...
Ansere, Victor A Ali-Mondal, Samim Sathiaseelan, Roshini Garcia, Driele N Isola, José V V Henseb, Jéssica D Saccon, Tatiana D Ocañas, Sarah R Tooley, Kyla B Stout, Michael B
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Published in
Mechanisms of ageing and development
Decline in ovarian reserve with advancing age is associated with reduced fertility and the emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent studies have provided insight into connections between ovarian insufficiency and systemic aging, although the basic mechanisms that promote ovarian reserve depletion remain unkno...
Barnes, Peter J
Published in
Current opinion in pharmacology
Increasing evidence suggests that there is acceleration of normal lung ageing in chronic obstructive pulmonary disease (COPD), with the accumulation of senescent cells in the lung, which release an array of inflammatory proteins, which drive further senescence and disease progression. This suggests that drugs that target cellular senescence (senoth...
Granata, Simona Benedetti, Claudia Gambaro, Giovanni Zaza, Gianluigi
Published in
Journal of nephrology
To add new molecular and pathogenetic insights into the biological machinery associated to kidney allograft fibrosis is a major research target in nephrology and organ transplant translational medicine. Interstitial fibrosis associated to tubular atrophy (IF/TA) is, in fact, an inevitable and progressive process that occurs in almost every type of ...
Omer, Amr Patel, Devang Moran, Julian Lucas Lian, Xian Jin Di Marco, Sergio Gallouzi, Imed-Eddine
Published in
Mechanisms of ageing and development
Stress granules (SGs) are membraneless organelles formed in response to insult. These granules are related to pathological granules found in age-related neurogenerative diseases such as Parkinson's and Alzheimer's. Previously, we demonstrated that senescent cells, which accumulate with age, exposed to chronic oxidative stress, are unable to form SG...
Georgakopoulou, Eleni A Valsamidi, Christina Veroutis, Dimitrios Havaki, Sophia
Published in
Mechanisms of ageing and development
The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of senescent cells or to neutralize...
Feroz, Wasim Sheikh, Arwah Mohammad Ali
Published in
Egyptian Journal of Medical Human Genetics
BackgroundCells have evolved balanced mechanisms to protect themselves by initiating a specific response to a variety of stress. The TP53 gene, encoding P53 protein, is one of the many widely studied genes in human cells owing to its multifaceted functions and complex dynamics. The tumour-suppressing activity of P53 plays a principal role in the ce...
Hong, Taeui Kim, Moon Young Da Ly, Dat Park, Su Jung Eom, Young Woo Park, Kyu-Sang Baik, Soon Koo
Published in
Stem Cell Research & Therapy
Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits various biological activities and reportedly increases mitochondrial biogenesis and respiration. Herein, we observed that Rg3 increased prolifera...
Luo, Xinxia Zhou, Junyang Wang, Zhixiao He, Yun Yu, Li Ma, Shinan Wang, Shan Wang, Xiaoli Yuan, Yahong Li, Dongsheng
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Published in
Life sciences
Cellular senescence, a process whereby cells enter a state of permanent growth arrest, appears to regulate cardiac pathological remodeling and dysfunction in response to various stresses including myocardial infarction (MI). However, the precise role as well as the underlying regulatory mechanism of cardiac cellular senescence in the ischemic heart...
Birder, Lori A. Wolf-Johnston, Amanda Wein, Alan J. Cheng, Fangzhou Grove-Sullivan, Mara Kanai, Anthony J. Watson, Alan M. Stoltz, Donna Watkins, Simon C. Robertson, Anne M.
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Published in
JCI Insight
In a preclinical model, 8-aminoguanine alleviates the functional and structural abnormalities in the aging urinary bladder.