Guiedem, Elise Pefura-Yone, Eric Walter Ikomey, George Mondinde Nkenfou, Céline Nguefeu Mesembe, Martha Yivala, Mbanyamsig Mispa Chendi, Bih Hycenta Jacobs, Graeme Brendon Chegou, Novel Njweipi Okomo, Marie Claire Assoumou
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Published in
BMC Immunology
BackgroundPrevious studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction and tobacco-related COPD have the same functional pathway characterized by p...
Saheera, Sherin Potnuri, Ajay Godwin Krishnamurthy, Prasanna
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm a...
Wu, Guanghao Wei, Wei Zhang, Jinfeng Nie, Weidong Yuan, Lan Huang, Yuanyu Zuo, Liping Huang, Lili Xi, Xiaobo Xie, Hai-Yan
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Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeti...
Rinaldi, Vera D. Donnard, Elisa Rasmussen, Morten Kucukural, Alper Yukselen, Onur Garber, Manuel Sharma, Upasna Rando, Oliver J.
Following testicular spermatogenesis, mammalian sperm continue to mature in a long epithelial tube known as the epididymis, which plays key roles in remodeling sperm protein, lipid, and RNA composition. To understand the roles for the epididymis in reproductive biology, we generated a single-cell atlas of the murine epididymis and vas deferens. We ...
Tan, Kun Song, Hye-Won Thompson, Merlin Munyoki, Sarah Sukhwani, Meena Hsieh, Tung-Chin Orwig, Kyle E Wilkinson, Miles F
Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have potential therapeutic value for treating male infertility, which afflicts >100 million men world-wide. While much has been learned about rodent SSCs, human SSCs remain poorly understood. Here, we molecularly characterize human SSCs and define conditions favoring the...
Petkovic, Maja Oses-Prieto, Juan Burlingame, Alma Jan, Lily Yeh Jan, Yuh Nung
Communication between organelles is essential for their cellular homeostasis. Neurodegeneration reflects the declining ability of neurons to maintain cellular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by regulating protein and lipid sorting and degradation. Here we report that TMEM16K, an endoplasmic reticu...
Padilla-Benavides, Teresita Reyes-Gutierrez, Pablo Imbalzano, Anthony N.
Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and activation of transcription factors. Chromatin remodeling enzymes utilize ATP hydrolysis to alter...
Zhang, Dai-Min Lin, Yu-Fung
ATP-sensitive potassium (KATP) channels couple cell metabolic status to membrane excitability and are crucial for stress adaptation and cytoprotection in the heart. Atrial natriuretic peptide (ANP), a cardiac peptide important for cardiovascular homeostasis, also exhibits cytoprotective features including protection against myocardial ischemia-repe...
Hernández-Montes, María del Socorro Mendoza-Santoyo, Fernando Flores Moreno, Mauricio de la Torre-Ibarra, Manuel Silva Acosta, Luis Palacios-Ortega, Natalith
Published in
Journal of the European Optical Society-Rapid Publications
Today digital holographic interferometry (DHI) is considered a modern full-field non-destructive technique that allows generating 3D quantitative data of a wide variety of specimens. There are diverse optical setups for DHI that enable the study of specimens in static and dynamic conditions: it is a viable alternative to characterize a wide diversi...
Arroyo, Armando Kim, Beomsu Yeh, John
The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle cyclic nucleotide levels which releases oocytes from the first meiotic arrest. In the ovarian follicle, the LH signal reduces cyclic nucleotide levels via the CNP/NPR2 s...
