He, Aoxiao Huang, Zhihao Feng, Qian Zhang, Shan Li, Fan Li, Dan Lu, Hongcheng Wang, Jiakun
Published in
Journal of translational medicine
This study investigates the molecular mechanisms of CC@AC&SF@PP NPs loaded with AC099850.3 siRNA and sorafenib (SF) for improving hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). A dataset of 44 HBV-HCC patients and their survival information was selected from the TCGA database. Immune genes related to survival status were identified u...
Cerbantez-Bueno, Vincent Serwatowska, Joanna Rodríguez-Ramos, Carolina Cruz-Valderrama, J de Folter, Stefan
We studied the D3-type cyclin function during gynoecium development in Arabidopsis and how they are related to the hormone cytokinin and the transcription factor SPATULA. Growth throughout the life of plants is sustained by cell division and differentiation processes in meristematic tissues. In Arabidopsis, gynoecium development implies a multiphas...
Zhang, Hangqi Li, Ming Zhou, Xueming Tang, Li Chen, Guangying Zhang, Yongmin
A series of combretastatin A-4 (CA-4) derivatives were designed and synthesized, which contain stilbene core structure with different linker, predominantly piperazine derivatives. These compounds were evaluated for their cytotoxic activities against four cancer cell lines, HCT116, A549, AGS, and SK-MES-1. Among them, compound 13 displayed the best ...
Lebeau, Grégorie Hoareau, Mathilde Rivière, Sébastien El Safadi, Daed da Silva, Christine Robert Krejbich-Trotot, Pascale Viranaicken, Wildriss
Alterations in cell cycle regulation contribute to Zika virus (ZIKV)-associated pathogenesis and may have implications for the development of therapeutic avenues. As a matter of fact, ZIKV alters cell cycle progression at multiple stages, including G1, S, G2, and M phases. During a cell cycle, the progression of mitosis is particularly controlled t...
Lu, Ruihui Zhu, Jingwen Li, Xin Zeng, Cheng Huang, Yan Peng, Chao Zhou, Yingfang Xue, Qing
Published in
Journal of genetics and genomics = Yi chuan xue bao
Endometriosis refers to as an estrogen-dependent disease. Estrogen receptor β (ERβ), the main estrogen receptor subtype which is encoded by the estrogen receptor 2 (ESR2) gene, can mediate the action of estrogen in endometriosis. Although selective estrogen receptor modulators can target the ERβ, they are not specific due to the wide distribution o...
Pashapour, Neda Dehghan-Nayeri, Mohammad Javad Babaei, Esmaeil Khalaj-Kondori, Mohammad Mahdavi, Majid
Published in
Journal of fluorescence
The fluoroquinolone class of antibiotics includes derivatives of the drug ciprofloxacin. These substances have recently been advocated for the treatment of cancer. In the current study, we examined the cytotoxicity and apoptosis-inducing potential of a novel synthetic ciprofloxacin derivative in the human myeloid leukemia KG1-a cell line. With an I...
Liu, Yuan Zou, Shao-Hui Gao, Xin
Published in
Genes & genomics
Bladder cancer is a prevalent malignancy. CDC20, a pivotal cell cycle regulator gene, plays a significant role in tumour cell proliferation, but its role in bladder cancer remains unclear. This study aimed to analyse CDC20 expression in bladder cancer and explore its roles in tumour progression, treatment response, patient prognosis, and cellular p...
Kasamoto, Manabu
京都大学 / 新制・課程博士 / 博士(医学) / 甲第25174号 / 医博第5060号 / 京都大学大学院医学研究科医学専攻 / (主査)教授 江藤 浩之, 教授 湊谷 謙司, 教授 松田 道行 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
Abouleisa, Riham R E Tang, Xian-Liang Ou, Qinghui Salama, Abou-Bakr M Woolard, Amie Hammouri, Dana Abdelhafez, Hania Cayton, Sarah Abdulwali, Sameeha K Arai, Momo
...
Published in
Cardiovascular research
Gene therapies to induce cardiomyocyte (CM) cell cycle re-entry have shown a potential to treat subacute ischaemic heart failure (IHF) but have not been tested in the more relevant setting of chronic IHF. Our group recently showed that polycistronic non-integrating lentivirus encoding Cdk1/CyclinB1 and Cdk4/CyclinD1 (TNNT2-4Fpolycistronic-NIL) is e...
Sesink, Anouk Becerra, Margaux Ruan, Jia-Ling Leboucher, Sophie Dubail, Maxime Heinrich, Sophie Jdey, Wael Petersson, Kristoffer Fouillade, Charles Berthault, Nathalie
...
AsiDNA™, a cholesterol-coupled oligonucleotide mimicking double-stranded DNA breaks, was developed to sensitize tumour cells to radio- and chemotherapy. This drug acts as a decoy hijacking the DNA damage response. Previous studies have demonstrated that standalone AsiDNA™ administration is well tolerated with no additional adverse effects when comb...
