Chen, Mingming Guo, Linlu Hao, Jie Ni, Jie Lv, Qunyu Xin, Xiaoyan Liao, Hong
Published in
Cellular and molecular neurobiology
Astrogliosis after brain trauma can have a significant impact on functional recovery. However, little is known about the mechanisms underlying astrocyte proliferation and subsequent astrogliosis. In this study, we established a cortical stab wound injury mouse model and observed dramatic astrocyte activation and nerve growth factor receptor (p75NTR...
Zhao, Na Gui, Xiao Fang, Qian Zhang, Rui Zhu, Weiye Zhang, Haorui Li, Qing Zhou, Yukun Zhao, Jiawei Cui, Xiao
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Published in
Journal of nanobiotechnology
Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and ocular vein occlusion, is one of the major reasons for vision loss, yet the therapeutic option is limited. Multiple nanoparticles have been reported to alleviate angiogenic retinopathy. However, the adverse ef...
Das, Arnika; Greco, Giulia; Kumar, Sujeet; Catanzaro, Elena; Morigi, Rita; Locatelli, Alessandra; Schols, Dominique; 9441; Alici, Hakan; Tahtaci, Hakan; Ravindran, Febina;
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In pursuit of an anticancer lead, a library of 1,2,3-triazole derivatives (7a-x) was prepared, characterized and screened for in vitro cytotoxicity in different cell lines. Most of the compounds proved to be cytotoxic with IC50 values in the low micromolar range. Further studies showed that the most active compound 7c induces caspase-dependent apop...
Ersöz, Nur Şebnem Adan, Aysun
Published in
Cytotechnology
Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its multi-targeted nature is a promising chemopreventive remaining limitedly studied in FLT3-ITD AML regarding to ceramide metabolism...
Fan, Jingyi Bellon, Marcia Ju, Mingyi Zhao, Lin Wei, Minjie Fu, Liwu Nicot, Christophe
Published in
Molecular cancer
FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in phosphorylation-dependent ubiquitination and proteasome degradation of oncoproteins that play critical role(s) in oncogenesi...
Fawzi, Mourad Oubella, Ali Bimoussa, Abdoullah Bamou, Fatima Zahra Khdar, Zein Alabdeen Auhmani, Aziz Riahi, Abdelkhalek Robert, Anthony Morjani, Hamid Itto, My Youssef Ait
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Published in
Computational biology and chemistry
3-Acetylisoxazolines were synthesized by the reaction of natural (R)-limonene and (R)-carvone with acetone in the presence of iron (III) nitrate. The reaction showed to be highly peri- and regioselective. Next, using a 1,3-dipolar cycloaddition reaction, the mono-3-acylisoxazolines derived from these monoterpenes were evaluated for their reactivity...
Duarte, Sâmia Sousa Silva, Daiana Karla Frade Lisboa, Thaís Mangeon Honorato Gouveia, Rawny Galdino de Andrade, Camyla Caroliny Neves de Sousa, Valgrícia Matias Ferreira, Rafael Carlos de Moura, Ricardo Olimpio Gomes, Joilly Nilce Santana da Silva, Patricia Mirella
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Published in
Pharmacological reports : PR
Acridine compounds have been described as promising anticancer agents. Previous studies showed that (E)-1'-((4-chlorobenzylidene)amino)-5'-oxo-1',5'-dihydro-10H-spiro[acridine-9,2'-pyrrole]-4'-carbonitrile (AMTAC-06), a spiro-acridine compound, has antitumor activity on Ehrlich tumor and low toxicity. Herein, we investigated its antitumor effect ag...
Guo, Yu-Qing Wang, Qiang Wang, Jun-Guo Gu, Ya-Jun Song, Pan-Pan Wang, Shou-Yu Qian, Xiao-Yun Gao, Xia
Published in
Experimental hematology & oncology
N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function. Here, we aimed to explore the biological function and clinical significance of m6A modification and METTL3 in head and neck squamous cell carcinoma (HNSCC). The prognostic...
Song, Soo Youn Lee, Si Yeo Ko, Young Bok Kim, Jinju Choi, Tae-Young Lee, Ki Hwan Yoo, Heon Jong Yuk, Jae Min
Published in
Gynecologic and Obstetric Investigation
Objective: In the present study, we attempted to identify the effects of fenofibrate on human cervical cancer cells. Methods: The cytotoxicity of fenofibrate in cervical cancer cells was determined by Cell Counting Kit-8. Immunoblotting assay was used to determine the protein expression of caspase-3, poly ADP-ribose polymerase cleavage, B-cell lymp...
Hassan Nazmy, Maiiada Ahmed Mekheimer, Ramadan Shoman, Mai E Abo-Elsebaa, Mohamed Abd-Elmonem, Mohamed Usef Sadek, Kamal
Published in
Bioorganic chemistry
Brain tumors are stubborn cancers with poor prognosis and disappointing survival rates. Targeted cancer therapeutics with higher efficacy and lower resistance are highly demanded. An efficient one-pot synthesis of polyfunctionalized phthalazines derivatives was developed by reacting ethyl 1-aryl-5-cyano-1,6-dihydro-4-methyl-6-oxo-3-pyridazine-carbo...