Pellegrini, Elisabeth Fernezelian, Danielle Malleret, Cassandra Gueguen, Marie-Madeleine Patche-Firmin, Jessica Rastegar, Sepand Meilhac, Olivier Diotel, Nicolas
Published in
The Journal of comparative neurology
The blood-brain barrier (BBB) is a physical interface between the blood and the brain parenchyma, playing key roles in brain homeostasis. In mammals, the BBB is established thanks to tight junctions between cerebral endothelial cells, involving claudin, occludin, and zonula occludens proteins. Estrogens have been documented to modulate BBB permeabi...
Kanaparthi, Dheeraj Lampe, Marko Krohn, Jan-Hagen Zhu, Baoli Klingl, Andreas Lueders, Tillmann
Published in
iScience
Bacterial protoplasts are known to reproduce independently of canonical molecular biological processes. Although their reproduction is thought to be influenced by environmental conditions, the growth of protoplasts in their natural habitat has never been empirically studied. Here, we studied the life cycle of protoplasts in their native environment...
Beauvais, Valentin Moreau, Kevin Žunar, Bojan Hervouet-Coste, Nadège Novačić, Ana Le Dantec, Aurélia Primig, Michael Mosrin-Huaman, Christine Stuparević, Igor Rahmouni, A.R.
...
The eukaryotic THO complex coordinates the assembly of so-called messenger RNA-ribonucleoprotein particles (mRNPs), a process that involves co-transcriptional coating nascent mRNAs with proteins. Once formed, mRNPs undergo quality control step marks them either for active transport to cytoplasm, or Rrp6/RNA exosome-mediated degradation in nucleus. ...
Yilmaz, Özlem Com, Emmanuelle Pineau, Charles Bobe, Julien
The specific functions and essentiality of type II vitellogenin (Vtg2) in early zebrafish development were investigated this study. A vtg2 -mutant line was produced effects genomic disturbance observed F2 females F3 offspring. No change transcript has been detected, however, Vtg2 abundance female liver 5×, 1 hpf embryos 3.8× less than Wt ( p andlt
Varland, Sylvia Silva, Rui Duarte Kjosås, Ine Faustino, Alexandra Bogaert, Annelies Billmann, Maximilian Boukhatmi, Hadi Kellen, Barbara Costanzo, Michael Drazic, Adrian
...
Published in
Nature communications
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin liga...
Boston, Ava M Dwead, Abdulrahman M Al-Mathkour, Marwah M Khazaw, Kezhan Zou, Jin Zhang, Qiang Wang, Guangdi Cinar, Bekir
Published in
iScience
The Polycomb group protein SCML2 and the transcriptional cofactor YAP1 regulate diverse cellular biology, including stem cell maintenance, developmental processes, and gene regulation in mammals and flies. However, their molecular and functional interactions are unknown. Here, we show that SCML2 interacts with YAP1, as revealed by immunological ass...
Xiang, Nan Xu, Hao Zhou, Zhou Wang, Junyu Cai, Pengfei Wang, Li Tan, Zhen Zhou, Yingbo Zhang, Tianping Zhou, Jiayuan
...
Published in
iScience
Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by lymphocytic infiltration and exocrine dysfunction, particularly affecting the salivary gland (SG). We employed single-cell RNA sequencing to investigate cellular heterogeneity in 11 patients with pSS and 5 non-SS controls. Notably, patients with pSS exhibited downregu...
Roberson, Elle C Tran, Ngan Kim Godambe, Anushka N Mark, Harrison Nguimtsop, Michelle Rust, Trinity Ung, Elizabeth Barker, LeCaine J Fitch, Rebecca D Wallingford, John B
...
Published in
iScience
Decades of work demonstrate that the mammalian estrous cycle is controlled by cycling steroid hormones. However, the signaling mechanisms that act downstream, linking hormonal action to the physical remodeling of the cycling uterus, remain unclear. To address this issue, we analyzed gene expression at all stages of the mouse estrous cycle. Striking...
Li, Zhuoyang Liu, Yaoxi Huang, Yiyong Tan, Qian Mei, Haibo Zhu, Guanghui Liu, Kun Yang, Ge
Published in
iScience
Congenital pseudarthrosis of the tibia (CPT) is a refractory condition characterized by the decreased osteogenic ability in tibial pseudarthrosis repair. Periosteal mesenchymal stem cells (PMSCs) are multipotent cells involved in bone formation regulation. However, the mechanisms underlying its role in CPT remain unclear. In this study, we observed...
Lavecchia, Angelo M Mantzouratou, Polyxeni Cerullo, Domenico Locatelli, Monica Conti, Sara Tironi, Matteo Sangalli, Fabio Corna, Daniela Zoja, Carlamaria Remuzzi, Giuseppe
...
Published in
iScience
Diabetes mellitus and alterations in thyroid hormone (TH) signaling are closely linked. Though the role of TH signaling in cell differentiation and growth is well known, it remains unclear whether its alterations contribute to the pathobiology of diabetic cells. Here, we aim to investigate whether the administration of exogenous T3 can counteract t...
