Goldberg, Rimma Scotta, Cristiano Cooper, Dianne Nissim-Eliraz, Einat Nir, Eilam Tasker, Scott Irving, Peter M Sanderson, Jeremy Lavender, Paul Ibrahim, Fowzia
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Published in
Gastroenterology
Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated whether proper function could be restored to Treg cells...
Roth, Theodore Lee
The immune system is central to the development and resolution of complex diseases that still challenge modern therapeutic medicine such as autoimmunity and cancer. Recent blunt immune system manipulations, such as systemic monoclonal antibodies, have shown great promise in subsets of these conditions. But more controlled therapeutic manipulation o...
Di Rocco, Giuliana Baldari, Silvia Gentile, Antonietta Capogrossi, Maurizio Toietta, Gabriele
Published in
Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Naseri, Mohammad Hassan Madani, Hoda Ahmadi Tafti, Seyed Hossein Moshkani Farahani, Maryam Kazemi Saleh, Davood Hosseinnejad, Hossein Hosseini, Saeid Hekmat, Sepideh Hossein Ahmadi, Zargham Dehghani, Majid
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Published in
Cell journal
The regenerative potential of bone marrow-derived mononuclear cells (MNCs) and CD133+ stem cells in the heart varies in terms of their pro-angiogenic effects. This phase II/III, multicenter and double-blind trial is designed to compare the functional effects of intramyocardial autologous transplantation of both cell types and placebo in patients wi...
Shah, Rahman Latham, Samuel B Khan, Sajjad A Shahreyar, Muhammad Hwang, Inyong Jovin, Ion S
Published in
Clinical cardiology
A substantial proportion of patients with coronary artery disease do not achieve complete revascularization and continue to experience refractory angina despite optimal medical therapy. Recently, stem cell therapy has emerged as a potential therapeutic option for these patients. However, findings of individual trials have been scrutinized because o...
Journal «Medical perspectives» Timchenko A.S. Zalessky V.N.
Published in
Medicni perspektivi (Medical perspectives)
Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the mielofibrosi...
Bi, Hong-Sen Zhang, Chen Nie, Fang-Fei Pan, Bo-Lin Xiao, E
Published in
Chinese medical journal
自体纳米活性脂肪细胞制备及基础研究和临床观察摘要背景：目前，脂肪填充技术已经广泛应用于整形和美容医学。然而，直接吸脂获得的脂肪组织颗粒较大，无法直接进行皮内注射。Tonnard报道的纳米脂肪通过物理方法从而获得了小颗粒的乳化脂肪。但是，该方法在处理脂肪过程中，脂肪细胞的活性被严重的破坏。 方法：本研究中，我们报道了一种新的先通过I型胶原酶化学消化，再离心获得小颗粒脂肪的方法。获得的脂肪组织包括脂肪细胞、脂肪祖细胞及间充质干细胞。我们将之命名为“纳米活性脂肪”。我们通过细胞集落形成实验、流式细胞术、成脂和成骨诱导，确定了获得的纳米活性脂肪中含有脂肪间充质干细胞活性成分。我们通过在裸鼠背部皮下注射纳米活性脂肪和纳米脂肪进行对比，研究了纳米脂肪在体移植后的存活能力。 结果：我们的结果显示，和传统的...
Skuk, Daniel Tremblay, Jacques P.
BACKGROUND: Transplantation of myogenic cells has potential applications in the treatment of muscle pathologies. Excluding purely autologous cell transplantation, graft viability depends on an adequate control of acute rejection (AR). To contribute in understanding AR in this context, we analyzed whether de novo circulating antibodies against donor...
Silvia Baldari Giuliana Di Rocco Martina Piccoli Michela Pozzobon Maurizio Muraca Gabriele Toietta
Published in
International Journal of Molecular Sciences
Cell-based therapies have the potential to revolutionize current treatments for diseases with high prevalence and related economic and social burden. Unfortunately, clinical trials have made only modest improvements in restoring normal function to degenerating tissues. This limitation is due, at least in part, to the death of transplanted cells wit...
Dietz, Allan B Dozois, Eric J Fletcher, Joel G Butler, Greg W Radel, Darcie Lightner, Amy L Dave, Maneesh Friton, Jessica Nair, Asha Camilleri, Emily T
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Published in
Gastroenterology
In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchym...
