The immune system is central to the development and resolution of complex diseases that still challenge modern therapeutic medicine such as autoimmunity and cancer. Recent blunt immune system manipulations, such as systemic monoclonal antibodies, have shown great promise in subsets of these conditions. But more controlled therapeutic manipulation o...
Published in Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Published in Medicni perspektivi (Medical perspectives)
Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the mielofibrosi...
Published in International Journal of Molecular Sciences
Cell-based therapies have the potential to revolutionize current treatments for diseases with high prevalence and related economic and social burden. Unfortunately, clinical trials have made only modest improvements in restoring normal function to degenerating tissues. This limitation is due, at least in part, to the death of transplanted cells wit...
Published in CNS Drugs
Cell therapy is considered a promising potential treatment for multiple sclerosis, perhaps particularly for the progressive form of the disease for which there are currently no useful treatments. Over the past two decades or more, much progress has been made in understanding the biology of MS and in the experimental development of cell therapy for ...
Published in Stem Cells International
Extracellular vesicles (EVs), such as microvesicles and exosomes, are membranous structures containing bioactive material released by several cells types, including mesenchymal stem/stromal cells (MSCs). Increasing lines of evidences point to EVs as paracrine mediators of the beneficial effects on tissue remodeling associated with cell therapy. A...
Published in International Journal of Molecular Sciences
Short-term persistence of transplanted cells during early post-implant period limits clinical efficacy of cell therapy. Poor cell survival is mainly due to the harsh hypoxic microenvironment transplanted cells face at the site of implantation and to anoikis, driven by cell adhesion loss. We evaluated the hypothesis that viral-mediated expression of...
Cardiovascular diseases (CVD) are the leading cause of death in developed societies. Vascular stem cells (VSCs) have been proposed as a cell population with regenerative potential for CVD. However, the in vivo ontogeny of VSCs remains controversial. In current study, we have isolated VSCs from the human term placenta and characterized in vivo cell ...
Published in Journal for ImmunoTherapy of Cancer
Published in Journal for ImmunoTherapy of Cancer
