Aminzadeh, Azadeh Tekiyeh Maroof, Neda Mehrabani, Mehrnaz Bahrampour Juybari, Kobra Sharifi, Ali Mohammad
Published in
Cell Journal (Yakhteh)
Objective This study aimed to investigate the reliability of diabetic adipose-derived stem cells (ADSCs) for autologous cell-based therapies by exploring the functionality of signalling pathways involved in regulating oxidative stress and apoptosis. Materials and Methods In this experimental study, ADSCs were isolated from streptozotocin (STZ)-indu...
Rodríguez Valiente, Mónica García Hernández, Ana María Almansa Saura, Sonia Bernabé García, Ángel Blanquer, Miguel LIARTE LASTRA, Sergio David Alcaraz Lorente, Patricio Castellanos Escrig, Gregorio Nicolás Villaescusa, Francisco José Moraleda Jiménez, José María
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Our objective was to determine the safety and efficacy of amniotic membrane (AM) treatment for epithelialization of complex diabetic foot ulcers, this tissue is obtained from healthy donors after scheduled caesarean section and negative serology for infectious diseases. Eighteen patients with diabetic macro and micro-angiopathy and foot deformation...
Venkat, Poornima Cui, Chengcheng Chopp, Michael Zacharek, Alex Wang, Fengjie Landschoot-Ward, Julie Shen, Yi Chen, Jieli
Published in
Stroke
Background and Purpose- Stroke patients with type 2 diabetes mellitus (T2DM) exhibit increased vascular and white matter damage and have worse prognosis compared with nondiabetic stroke patients. We investigated the neurorestorative effects of exosomes derived from mouse brain endothelial cells (EC-Exo) as treatment for stroke in T2DM mice and inve...
Bajouri, Amir Orouji, Zahra Taghiabadi, Ehsan Nazari, Abdoreza Shahbazi, Atefeh Fallah, Nasrin Mohammadi, Parvaneh Rezvani, Mohammad Jouyandeh, Zahra Vaezirad, Fatemeh
...
Published in
Cell Journal (Yakhteh)
Objective Recently, the promising potential of fibroblast transplantation has become a novel modality for skin rejuvenation. We investigated the long-term safety and efficacy of autologous fibroblast transplantation for participants with mild to severe facial contour deformities. Materials and Methods In this open-label, single-arm phase IIa clinic...
Williams, Ian M Wu, Joseph C
Published in
Arteriosclerosis, thrombosis, and vascular biology
Endothelial cells (ECs) are critical for several aspects of cardiovascular disease therapy, including vascular regeneration, personalized drug development, and tissue engineering. Human pluripotent stem cells (hPSCs) afford us with an unprecedented opportunity to produce virtually unlimited quantities of human ECs. In this review, we highlight key ...
Esmaeilzadeh, Abbas Ommati, Homeira Kooshyar, Mohammad Mahdi Jarahi, Lida Akhavan Rezayat, Kambiz Saberi, Samaneh Vosough, Massoud Ghassemi, Ali
Published in
Cell Journal (Yakhteh)
Objective Liver transplantation is the gold standard approach for decompensated liver cirrhosis. In recent years, stem cell therapy has raised hopes that adjusting some clinical and laboratory parameters could lead to successful treatments for this disease. Cirrhotic patients may have multiple systemic abnormalities in peripheral blood and irregula...
Sun, Yuan Chen, Song Zhang, Xicheng Pei, Ming
Published in
Arteriosclerosis, thrombosis, and vascular biology
Adult stem cell-based therapy has been regarded as a promising treatment for tissue ischemia because of its ability to promote new blood vessel formation. Bone marrow-derived mesenchymal stem cells are the most used angiogenic cells for therapeutic neovascularization, yet the side effects and low efficacy have limited their clinical application. Ad...
Goldberg, Rimma Scotta, Cristiano Cooper, Dianne Nissim-Eliraz, Einat Nir, Eilam Tasker, Scott Irving, Peter M Sanderson, Jeremy Lavender, Paul Ibrahim, Fowzia
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Published in
Gastroenterology
Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated whether proper function could be restored to Treg cells...
Hopewell, Emily L Cox, Cheryl Pilon-Thomas, Shari Kelley, Linda L
Published in
Cytotherapy
Adoptive cell therapy of tumor-infiltrating lymphocytes has shown promise for treatment of refractory melanoma and other solid malignancies; however, challenges to manufacturing have limited its widespread use. Traditional manufacturing efforts were lengthy, cumbersome and used open culture systems. We describe changes in testing and manufacturing ...
Trac, David Maxwell, Joshua T Brown, Milton E Xu, Chunhui Davis, Michael E
Published in
Circulation research
Congenital heart disease can lead to life-threatening right ventricular (RV) heart failure. Results from clinical trials support expanding cardiac progenitor cell (CPC) based therapies. However, our recent data show that CPCs lose function as they age, starting as early as 1 year. To determine whether the aggregation of child (1-5-year-old) CPCs in...
