Journal «Medical perspectives» Timchenko A.S. Zalessky V.N.
Published in
Medicni perspektivi (Medical perspectives)
Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the mielofibrosi...
Silvia Baldari Giuliana Di Rocco Martina Piccoli Michela Pozzobon Maurizio Muraca Gabriele Toietta
Published in
International Journal of Molecular Sciences
Cell-based therapies have the potential to revolutionize current treatments for diseases with high prevalence and related economic and social burden. Unfortunately, clinical trials have made only modest improvements in restoring normal function to degenerating tissues. This limitation is due, at least in part, to the death of transplanted cells wit...
Published in
Stem Cells International
Extracellular vesicles (EVs), such as microvesicles and exosomes, are membranous structures containing bioactive material released
by several cells types, including mesenchymal stem/stromal cells (MSCs). Increasing lines of evidences point to EVs as paracrine
mediators of the beneficial effects on tissue remodeling associated with cell therapy. A...
Lagarrigue, Mélanie Guével, Blandine Ledevin, Mireille Larcher, Thibaut Dubreil, Laurence Charles Pineau Rouger, Karl Guével, Laétitia Lardenois, Aurélie Jagot, Sabrina
...
Proteomic profiling plays a decisive role in the elucidation of molecular signatures representative of a specific clinical context. MuStem cell-based therapy represents a promising approach for clinical applications to cure Duchenne Muscular Dystrophy (DMD). To expand our previous studies collected in the clinically relevant DMD animal model, we de...
Silvia Baldari Giuliana Di Rocco Angelo Trivisonno Daniela Samengo Giovambattista Pani Gabriele Toietta
Published in
International Journal of Molecular Sciences
Short-term persistence of transplanted cells during early post-implant period limits clinical efficacy of cell therapy. Poor cell survival is mainly due to the harsh hypoxic microenvironment transplanted cells face at the site of implantation and to anoikis, driven by cell adhesion loss. We evaluated the hypothesis that viral-mediated expression of...
Shafiee, Abbas
Cardiovascular diseases (CVD) are the leading cause of death in developed societies. Vascular stem cells (VSCs) have been proposed as a cell population with regenerative potential for CVD. However, the in vivo ontogeny of VSCs remains controversial. In current study, we have isolated VSCs from the human term placenta and characterized in vivo cell ...
Mitutsova, Violeta
L'utilisation des cellules souches est une approche prometteuse pour le traitement des maladies dégénératives neuromusculaires. De nombreuses études portent actuellement sur les cellules souches embryonnaires (ES) et les cellules pluripotentes induites par reprogrammation (IPs) dont l'utilisation en médecine régénérative reste sujette à caution à c...
Mitutsova, Violeta
L'utilisation des cellules souches est une approche prometteuse pour le traitement des maladies dégénératives neuromusculaires. De nombreuses études portent actuellement sur les cellules souches embryonnaires (ES) et les cellules pluripotentes induites par reprogrammation (IPs) dont l'utilisation en médecine régénérative reste sujette à caution à c...
Mitutsova, Violeta
L'utilisation des cellules souches est une approche prometteuse pour le traitement des maladies dégénératives neuromusculaires. De nombreuses études portent actuellement sur les cellules souches embryonnaires (ES) et les cellules pluripotentes induites par reprogrammation (IPs) dont l'utilisation en médecine régénérative reste sujette à caution à c...
Sharma, Alok Sane, Hemangi Kulkarni, Pooja D'sa, Myola Gokulchandran, Nandini Badhe, Prerna
Published in
Cell journal
Cerebral palsy (CP) is a non progressive, demyelinating disorder that affects a child's development and posture and may be associated with sensation, cognition, communication and perception abnormalities. In CP, cerebral white matter is injured resulting in the loss of oligodendrocytes. This causes damage to the myelin and disruption of nerve condu...
