Tu, Mei-Juan Duan, Zhijian Liu, Zhenzhen Zhang, Chao Bold, Richard J Gonzalez, Frank J Kim, Edward J Yu, Ai-Ming
Cancer cells are dysregulated and addicted to continuous supply and metabolism of nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of critical macromolecules for uncontrolled growth. Recent studies have revealed that genome-derived microRNA (miRNA or miR)-1291-5p (miR-1291-5p or miR-1291) may modulate the expression of ar...
S, Mohammadi E, Soratijahromi R, Dehdari Vais N, Sattarahmady
Published in
Journal of biomedical physics & engineering
As an alternative form of cancer therapy, photothermal therapy (PTT) and sonodynamic therapy (SDT) using nanomaterials are in development. Nanomaterials can act as energy absorber as well as anti-cancer agent. In this study, the effects of laser and ultrasound irradiation with Se-PEG-Cur nanoparticles were investigated on melanoma cancer. In this e...
Engels, Elette Bakr, Samer Bolst, David Sakata, Dousatsu Li, Nan Lazarakis, Peter Mcmahon, Stephen Ivanchenko, Vladimir Rosenfeld, Anatoly Incerti, Sébastien
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Gold nanoparticles have demonstrated significant radiosensitization of cancer treatment with X-ray radiotherapy. To understand the mechanisms at the basis of nanoparticle radiosensitization, Monte Carlo simulations are used to investigate the dose enhancement, given a certain nanoparticle concentration and distribution in the biological medium. Ear...
Hu, Ke Liu, Xianhao Li, Yi Li, Qinyang Xu, Yijun Zeng, Wei Zhong, Guocheng Yu, Changhua
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Circular RNA UBE2D2 (circ_UBE2D2) has been found to be involved in the progression of breast cancer. Exosomes are critical mediators of intercellular communication, however, the function of exosomal circ_UBE2D2 in breast cancer remains vague. Material/Methods Cell viability was measured by Cell Counting Kit-8 assay. Western blot was used...
Geng, Hanke Li, Kaixuan Pan, Qi Tao, Shaohui Li, Chunjuan Zhao, Haiwei Zhao, Xiaojun
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Gastric cancer (GC) remains one of the most fatal digestive cancers in the world; nevertheless, its etiology remains vague. With the development of bioinformatics analysis, numerous circular RNAs (circRNAs) have been found to be dysregulated in GC. However, the functions of a large portion of dysregulated circRNAs in GC need further vali...
Corominas-Murtra, Bernat Scheele, Colinda LGJ Kishi, Kasumi Ellenbroek, Saskia IJ Simons, Benjamin van Rheenen, Jacco Hannezo, Edouard
Understanding to what extent stem cell potential is a cell-intrinsic property, or an emergent behavior coming from global tissue dynamics and geometry, is a key outstanding question of systems and stem cell biology. Here, we propose a theory of stem cell dynamics as a stochastic competition for access to a spatially-localized niche, giving rise to ...
Oliveira, Nelson GJ Cardoso, Marlon H Velikova, Nadya Giesbers, Marcel Wells, Jeremy Rezende, Taia MB de Vries, Renko Franco, Octávio L
Dufey, Estefanie Bravo-San Pedro, José Manuel Eggers, Cristian González-Quiroz, Matías Urra, Hery Sagredo, Alfredo I Sepulveda, Denisse Pihán, Philippe Carreras-Sureda, Amado Hazari, Younis
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The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic stress to modulate repair programs and sustain cell survival. DNA damage engages IRE1α signaling in the absence ...
Houshdaran, Sahar Chen, Joseph C Vallvé-Juanico, Júlia Balayan, Shayna Vo, Kim Chi Smith-McCune, Karen Greenblatt, Ruth M Irwin, Juan C Giudice, Linda C
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of administration, little is known about their effects on the endometrial transcriptome in the presence ...
Shen, Yaoyao Sun, Fan Zhang, Liu Cheng, Yijia Zhu, Hongrui Wang, Shu-Ping Jiao, Wei-Hua Leadlay, Peter Zhou, Yongjun Lin, Hou-Wen
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