Alexander, Samuel Hibbard, Bill
Published in
Journal of Artificial General Intelligence
In 2011, Hibbard suggested an intelligence measure for agents who compete in an adversarial sequence prediction game. We argue that Hibbard’s idea should actually be considered as two separate ideas: first, that the intelligence of such agents can be measured based on the growth rates of the runtimes of the competitors that they defeat; and second,...
Meyer, Kirstin Lammers, Nicholas Bugaj, Lukasz Garcia, Hernan Weiner, Orion
YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How cells ensure the selective activation of YAP effector genes is unknown. This knowledge is essential to rationally control cellular decision-making. Here we leverage optogenetics, live-imaging of transcription, and cell fate analysis to understand and co...
Rundberg Nilsson, Alexandra Shalapour, Shabnam Cammenga, Jörg Karin, Michael Xian, Hongxu
Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We...
Andrews, Madeline Siebert, Clara Wang, Li White, Matthew Ross, Jayden Morales, Raul Donnay, Megan Bamfonga, Gradi McKinney, Arpana Gemenes, Kaila
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Radial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia. However, the mechanisms regulating oRG differentiation are unclear. oRG cells express leukemia-inhibitory factor (LIF) receptors during neurogenesis, and consi...
Alimohammadi, Shahrzad Masuda-Kuroki, Kana Szöllősi, Attila Di Nardo, Anna
Mast cells (MCs) are tissue-resident immune cells of a hematopoietic origin that play vital roles in innate and adaptive immunity. Human MCs can be isolated and differentiated from various tissue sources, including cord blood, when supplemented with cytokines such as stem cell factor, interleukin 3, and interleukin 6. Our current research study has...
Reeves, Daniel Bacchus-Souffan, Charline Fitch, Mark Abdel-Mohsen, Mohamed Hoh, Rebecca Ahn, Haelee Stone, Mars Hellerstein, Marc McCune, Joseph Schiffer, Joshua
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Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional- (T...
Wang, Xinyi Nie, Qing Almet, Axel
Cell-cell interactions instruct cell fate and function. These interactions are hijacked to promote cancer development. Single-cell transcriptomics and spatial transcriptomics have become powerful new tools for researchers to profile the transcriptional landscape of cancer at unparalleled genetic depth. In this review, we discuss the rapidly growing...
Pham, Paula Lu, Hanbin Han, Han Zhou, Jeff Madan, Aarushi Murre, Cornelis Cho, Ken Wang, Wenqi
The mechanism by which transcription factor (TF) network instructs cell-type-specific transcriptional programs to drive primitive endoderm (PrE) progenitors to commit to parietal endoderm (PE) versus visceral endoderm (VE) cell fates remains poorly understood. To address the question, we analyzed the single-cell transcriptional signatures defining ...
Veniaminova, Natalia Jia, Yunlong Hartigan, Adrien Huyge, Thomas Tsai, Shih-Ying Grachtchouk, Marina Nakagawa, Seitaro Dlugosz, Andrzej Wong, Sunny Atwood, Scott
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Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs are largely self-renewed by dedicated stem cell pools during homeostasis. Using targeted single-cell RNA sequencing, we uncovered both direct and indirect paths by which resident SG progenitors...
Morey, Robert Bui, Tony Horii, Mariko Fisch, Kathleen
Our current knowledge of the cellular and molecular mechanisms of placental epithelial cells, trophoblast, primarily came from the use of mouse trophoblast stem cells and tumor-derived or immortalized human trophoblast cell lines. This was mainly due to the difficulties in maintaining primary trophoblast in culture and establishing human trophoblas...