Lin, Ziguang Jin, Suoqin Chen, Jefferson Li, Zhuorui Lin, Zhongqi Tang, Li Nie, Qing Andersen, Bogi
The interfollicular epidermis (IFE) forms a water-tight barrier that is often disrupted in inflammatory skin diseases. During homeostasis, the IFE is replenished by stem cells in the basal layer that differentiate as they migrate toward the skin surface. Conventionally, IFE differentiation is thought to be stepwise as reflected in sharp boundaries ...
Watson, Christine Khaled, Walid
The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psych...
Yang, Bing Rifkin, Scott A
The speed at which a cell fate decision in nematode worms evolves is due to the number of genes that control the decision, rather than to a high mutation rate.
Aalders, Jeffrey Léger, Laurens Van der Meeren, Louis Van den Vreken, Natasja Skirtach, Andre G Sinha, Sanjay De Backer, Julie van Hengel, Jolanda
Krivanek, Jan Soldatov, Ruslan A Kastriti, Maria Eleni Chontorotzea, Tatiana Herdina, Anna Nele Petersen, Julian Szarowska, Bara Landova, Marie Matejova, Veronika Kovar Holla, Lydie Izakovicova
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Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of...
Sznurkowska, Magdalena K Hannezo, Edouard Azzarelli, Roberta Chatzeli, Lemonia Ikeda, Tatsuro Yoshida, Shosei Philpott, Anna Simons, Benjamin
Pancreatic islets play an essential role in regulating blood glucose level. Although the molecular pathways underlying islet cell differentiation are beginning to be resolved, the cellular basis of islet morphogenesis and fate allocation remain unclear. By combining unbiased and targeted lineage tracing, we address the events leading to islet forma...
Miesfeld, Joel B Ghiasvand, Noor M Marsh-Armstrong, Brennan Marsh-Armstrong, Nicholas Miller, Eric B Zhang, Pengfei Manna, Suman K Zawadzki, Robert J Brown, Nadean L Glaser, Tom
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The retinal ganglion cell (RGC) competence factor ATOH7 is dynamically expressed during retinal histogenesis. ATOH7 transcription is controlled by a promoter-adjacent primary enhancer and a remote shadow enhancer (SE). Deletion of the ATOH7 human SE causes nonsyndromic congenital retinal nonattachment (NCRNA) disease, characterized by optic nerve a...
Sha, Yutong Wang, Shuxiong Zhou, Peijie Nie, Qing
Rapid growth of single-cell transcriptomic data provides unprecedented opportunities for close scrutinizing of dynamical cellular processes. Through investigating epithelial-to-mesenchymal transition (EMT), we develop an integrative tool that combines unsupervised learning of single-cell transcriptomic data and multiscale mathematical modeling to a...
Hsu, Jingmei Huang, Hsuan-Ting Lee, Chung-Tsai Choudhuri, Avik Wilson, Nicola Abraham, Brian J Moignard, Victoria Kucinski, Iwo Yu, Shuqian Hyde, R Katherine
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Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish...
He, Peng Williams, Brian A Trout, Diane Marinov, Georgi K Amrhein, Henry Berghella, Libera Goh, Say-Tar Plajzer-Frick, Ingrid Afzal, Veena Pennacchio, Len A
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During mammalian embryogenesis, differential gene expression gradually builds the identity and complexity of each tissue and organ system1. Here we systematically quantified mouse polyA-RNA from day 10.5 of embryonic development to birth, sampling 17 tissues and organs. The resulting developmental transcriptome is globally structured by dynamic cyt...