Naked mole-rat cortical neurons are resistant to acid-induced cell death.
Stat3-mediated alterations in lysosomal membrane protein composition.
Lysosome function is essential in cellular homeostasis. In addition to its recycling role, the lysosome has recently been recognised as a cellular signalling hub. We have shown in mammary epithelial cells, both in vivo and in vitro, that signal transducer and activator of transcription 3 (Stat3) modulates lysosome biogenesis and can promote the rel...
HCV感染はJNKリン酸化を介して肝細胞のリポアポトーシスを増強させる
Citation: Medical Science Monitor, 23, pp.4526-4532; 2017
Live imaging of neurogenesis in the adult mouse hippocampus.
Neural stem/progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1)-promoter undergo limited ro...
Live imaging of neurogenesis in the adult mouse hippocampus.
Neural stem/progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1)-promoter undergo limited ro...
OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model
...
Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and cell survival. Hereditary optic neuropathies are com...
OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model
...
Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and cell survival. Hereditary optic neuropathies are com...
OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model
...
Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and cell survival. Hereditary optic neuropathies are com...
OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model
...
Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and cell survival. Hereditary optic neuropathies are com...
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...
...Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
