Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms in frontotemporal dementia. We identify two gene coexpression modules that are preserved in mice harboring mutations in MAPT, GRN and other ...
Saikosaponins (SSs) are a class of naturally occurring oleanane-type triterpenoid saponins found in Radix bupleuri that has been widely used in traditional Chinese medicine. As the main active principals of Radix bupleuri, SSs have been shown to suppress mouse motor activity, impair learning and memory, and decrease hippocampal neurogenesis. In the...
Work in the authors’ laboratories relevant to the topic has been supported by The Wellcome Trust, The Medical Research Council, Alzheimer’s Research UK, and the National Council for the Relacement, Refinement, and Reduction of Animals in Research (the NC3Rs).
Work in the authors’ laboratories relevant to the topic has been supported by The Wellcome Trust, The Medical Research Council, Alzheimer’s Research UK, and the National Council for the Relacement, Refinement, and Reduction of Animals in Research (the NC3Rs).
