Li, Xin-Yu Cui, Xuan Xie, Chang-Quan Wu, Yong Song, Tang He, Jin-Di Feng, Ji Cui, Qian-Ru Bin, Jin-Lian Li, Qiu-Yun
...
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Hepatocellular carcinoma (HCC) is a highly lethal cancer characterized by dominant driver mutations, including p53. Consequently, there is an urgent need to search for novel therapeutic agents to treat HCC. Andrographolide (Andro), a clinically available anti-inflammatory phytochemical agent, has shown inhibitory effects against various types of ca...
Polloni, Lorena Costa, Tássia Rafaella Morais, Lorena Pinheiro Borges, Bruna Cristina Teixeira, Samuel Cota de Melo Fernandes, Thales Alves Correia, Lucas Ian Veloso Bastos, Luciana Machado Gobbi Amorim, Fernanda Quinton, Loïc
...
peer reviewed / Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to promote their malignant phenotype. In this framework, we hypothesized that the change in ROS concentration above threshold could impair key events of prostate cancer cells (PC-3) progression. Our results demonstrated that Pollonein-LAAO, a new L...
Li, Xing Liu, Kaida Xing, Lidong Rubinsky, Boris
BACKGROUND: Tumor Treating Fields (TTFields) is a non-invasive modality for cancer treatment that utilizes a specific sinusoidal electric field ranging from 100 kHz to 300 kHz, with an intensity of 1 V/cm to 3 V/cm. Its purpose is to inhibit cancer cell proliferation and induce cell death. Despite promising outcomes from clinical trials, TTFields h...
Asaro, Robert J Profumo, Elisabetta Buttari, Brigitta Cabrales, Pedro
Their widespread presence throughout the vasculature, coupled with their reactivity, and thereby to their potential to release reactive oxidative species, or to utilize their anti-oxidative capacities, has promoted much discussion of the role(s) of red blood cells (RBCs) in the progression of health or, alternatively, a wide range of disease states...
Vitale, Ilio Pietrocola, Federico Guilbaud, Emma Aaronson, Stuart A Abrams, John M Adam, Dieter Agostini, Massimiliano Agostinis, Patrizia Alnemri, Emad S Altucci, Lucia
...
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiolo...
Vitale, Ilio Pietrocola, Federico Guilbaud, Emma Aaronson, Stuart A Abrams, John M Adam, Dieter Agostini, Massimiliano Agostinis, Patrizia Alnemri, Emad S Altucci, Lucia
...
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiolo...
Vitale, I Pietrocola, F Guilbaud, E Aaronson, SA Abrams, JM Adam, D Agostini, M Agostinis, P Alnemri, ES Altucci, L
...
10.1038/s41418-023-01153-w / Cell Death and Differentiation / 30 / 5 / 1097-1154
Jeon, Yusun Chow, Seong H Stuart, Isabella Weir, Ashley Yeung, Amy Ty Hale, Christine Sridhar, Sushmita Dougan, Gordon Vince, James E Naderer, Thomas
...
Staphylococcus aureus causes severe infections such as pneumonia and sepsis depending on the pore-forming toxin Panton-Valentine leukocidin (PVL). PVL kills and induces inflammation in macrophages and other myeloid cells by interacting with the human cell surface receptor, complement 5a receptor 1 (C5aR1). C5aR1 expression is tighly regulated and m...
Woodley, Keith Dillingh, Laura S Giotopoulos, George Madrigal, Pedro Rattigan, Kevin M Philippe, Céline Dembitz, Vilma Magee, Aoife MS Asby, Ryan van de Lagemaat, Louie N
...
Funder: American Society of Hematology / Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate isomerase (MPI), the first enzyme in the mannose metabolism pathw...
Hesse, Friederike Wright, Alan Bulat, Flaviu Kreis, Felix Brindle, Kevin M
Funder: Cambridge Trust; doi: http://dx.doi.org/10.13039/501100005370 / Imaging the metabolism of [2,3-2 H2 ]fumarate to produce malate can be used to detect tumor cell death post-treatment. Here, we assess the sensitivity of the technique for detecting cell death by lowering the concentration of injected [2,3-2 H2 ]fumarate and by varying the exte...
