Nasrolahi, Ava Hosseini, Leila Farokhi-Sisakht, Fatemeh Mahmoudi, Javad Karimi, Pouran Badalzadeh, Reza Erfani, Marjan
Published in
Journal of Cardiovascular and Thoracic Research
Introduction: Overexposure to heat conditions can affect the functioning of the cardiovascular system and may promote cardiovascular disorders. Heat shock induced myocardial injury via increasing endoplasmic reticulum response-mediated apoptosis. This study investigated the impact of pretreatment with Rosa canina (RC), a natural antioxidant, on myo...
McQuade, Amanda Kang, You Jung Hasselmann, Jonathan Jairaman, Amit Sotelo, Alexandra Coburn, Morgan Shabestari, Sepideh Kiani Chadarevian, Jean Paul Fote, Gianna Tu, Christina H
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The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine this question, we profile microglia differentiated from...
Liu, Yan Xu, Zhennan Jin, Tao Xu, Ke Liu, Mingfa Xu, Haixiong
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The extent of glioma resection influences the overall survival (OS) and progression-free survival (PFS). Ferroptosis is a newly recognized type of cell death, which may be associated with low-grade glioma border detection and OS. This study is assessed an optimized ferroptosis gene panel for glioma treatment. Material/Methods We obtained...
Rolfes, Verena Ribeiro, Lucas Secchim Hawwari, Ibrahim Böttcher, Lisa Rosero, Nathalia Maasewerd, Salie Santos, Marina Lima Silva Próchnicki, Tomasz Silva, Camila Meirelles de Souza Wanderley, Carlos Wagner de Souza
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Published in
Cell Reports
Rolfes et al. show that platelets license NLRP3 expression in immune cells, boost inflammasome responses in vitro , and are critical for full IL-1 responses in vivo . A platelet-gene signature is present in NLRP3-related autoinflammatory diseases. Soluble platelet factors enhance NLRP3 transcription and boost IL-1 in macrophages.
Wu, Pui-Kei Hong, Seung-Keun Starenki, Dmytro Oshima, Kiyoko Shao, Hao Gestwicki, Jason E Tsai, Susan Park, Jong-In
The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can selectively induce death of immortalized normal fibroblasts IMR90E1A when combined with K-RasG12V expression, but not with wild-type K-Ras expression, and that K-RasG12V-driven MEK/E...
Wang, Hongzhou Zhang, Shunwen Zhao, Haijun Qin, Huiyuan Zhang, Jie Dong, Jiangtao Zhang, Hui Liu, Xiaoling Zhao, Zhengyong Zhao, Yanheng
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Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis. Pyroptosis, or cell death associated with sepsis, is mediated by caspase-1 activation. This study aimed to investigate the role of CO on the expression of proteins associated with intestinal mucosal pyroptosis in a rat model of sepsi...
Lafont, Elodie
Published in
Cancers
Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from prolife...
Mayr, Lisa Grabherr, Felix Schwärzler, Julian Reitmeier, Isabelle Sommer, Felix Gehmacher, Thomas Niederreiter, Lukas He, Gui-Wei Ruder, Barbara Kunz, Kai TR
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The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA), which entails risk for developing IBD. Glutathione peroxida...
Jardine, Sasha Anderson, Sierra Babcock, Stephen Leung, Gabriella Pan, Jie Dhingani, Neel Warner, Neil Guo, Conghui Siddiqui, Iram Kotlarz, Daniel
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Published in
Gastroenterology
Mutations in the tetratricopeptide repeat domain 7A gene (TTC7A) cause intestinal epithelial and immune defects. Patients can become immune deficient and develop apoptotic enterocolitis, multiple intestinal atresia, and recurrent intestinal stenosis. The intestinal disease in patients with TTC7A deficiency is severe and untreatable, and it recurs d...
Bolus, Stephen Akhunov, Eduard Coaker, Gitta Dubcovsky, Jorge
Nucleotide-binding leucine-rich repeat receptors (NLRs) are the most abundant type of immune receptors in plants and can trigger a rapid cell-death (hypersensitive) response upon sensing pathogens. We previously cloned the wheat NLR Sr35, which encodes a coiled-coil (CC) NLR that confers resistance to the virulent wheat stem rust race Ug99. Here, w...
