Preston, Simon P Stutz, Michael D Allison, Cody C Nachbur, Ueli Gouil, Quentin Tran, Bang Manh Duvivier, Valerie Arandjelovic, Philip Cooney, James P Mackiewicz, Liana
...
Published in
Gastroenterology
Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/ nonalcoholic steatohepatitis (NASH); however, the evidence supporting these claims has been controversial. A comprehensive, fundamental understanding of cell death pathways involved in liver disease critically underp...
Mishchenko, Tatiana Balalaeva, Irina Gorokhova, Anastasia Vedunova, Maria Krysko, Dmitri V
Published in
Cell death & disease
Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of sev...
Watson, Christine J
The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of lactation. The milk-producing cells arise primarily during pregnancy and comprise the alveolar lineage that is specified by signal...
Gao, Zongyu Zhang, Dingliang Wang, Xiaoling Zhang, Xin Wen, Zhiyan Zhang, Qianshen Li, Dawei Dinesh-Kumar, Savithramma P Zhang, Yongliang
Mitogen-activated protein kinase (MAPK) cascades play an important role in innate immunity against various pathogens in plants and animals. However, we know very little about the importance of MAPK cascades in plant defense against viral pathogens. Here, we used a positive-strand RNA necrovirus, beet black scorch virus (BBSV), as a model to investi...
Kroken, Abby R Gajenthra Kumar, Naren Yahr, Timothy L Smith, Benjamin E Nieto, Vincent Horneman, Hart Evans, David J Fleiszig, Suzanne MJ
The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity. For epithelial cells, this involves inhibiting vacuole acidification, promoting vacuolar escape, countering autophagy, and niche construction in the cytoplasm and within plasma m...
Robarts, Dakota R McGreal, Steven R Umbaugh, David S Parkes, Wendena S Kotulkar, Manasi Abernathy, Sarah Lee, Norman Jaeschke, Hartmut Gunewardena, Sumedha Whelan, Stephen A
...
Published in
Cellular and molecular gastroenterology and hepatology
The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is a critical termination signal for liver regeneration following partial hepatecto...
Wang, Meiying Ishikawa, Tatsuya Lai, Yupeng Nallapothula, Dhiraj Singh, Ram Raj
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released. NETs normally contribute to host immune defense. Accumulating evidence implicates aberrant NET production ...
Liu, Ke Liu, Jiao Zou, Borong Li, Changfeng Zeh, Herbert J Kang, Rui Kroemer, Guido Huang, Jun Tang, Daolin
Published in
Cellular and molecular gastroenterology and hepatology
Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a serine protease secreted by pancreatic acinar cells, affects the contribution of ferroptosis to triggering pancreatitis. ...
Catanzaro, Elena Turrini, Eleonora Kerre, Tessa Sioen, Simon Baeyens, Ans Guerrini, Alessandra Bellau, Mohamed Lamin Abdi Sacchetti, Gianni Paganetto, Guglielmo Krysko, Dmitri
...
Ferroptosis induction is an emerging strategy to treat cancer and contrast the tricky issue of chemoresistance, which can arise towards apoptosis. This work elucidates the anticancer mechanisms evoked by perillaldehyde, a monoterpenoid isolated from Ammodaucus leucotrichus Coss. & Dur. We investigated and characterized its antileukemic potential in...
McCreedy, Dylan A Abram, Clare L Hu, Yongmei Min, Sun Won Platt, Madison E Kirchhoff, Megan A Reid, Shelby K Jalufka, Frank L Lowell, Clifford A
BackgroundSpinal cord injury elicits widespread inflammation that can exacerbate long-term neurologic deficits. Neutrophils are the most abundant immune cell type to invade the spinal cord in the early acute phase after injury, however, their role in secondary pathogenesis and functional recovery remains unclear. We have previously shown that neutr...
