Ikonomov, Ognian C Sbrissa, Diego Shisheva, Assia
Published in
Toxicology and applied pharmacology
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in culture yet trigger non-apoptotic death through exces...
Wong, Jerry Zelic, Matija Bertin, John Kelliher, Michelle A. Guma, Monica
BACKGROUND AND AIMS: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. Here, we investigated how chronic nuclear factor (NF)- kappaB activation, which occurs i...
Chapman, Margaret P Risom, Tyler Aswani, Anil J Langer, Ellen M Sears, Rosalie C Tomlin, Claire J
Drug resistance in breast cancer cell populations has been shown to arise through phenotypic transition of cancer cells to a drug-tolerant state, for example through epithelial-to-mesenchymal transition or transition to a cancer stem cell state. However, many breast tumors are a heterogeneous mixture of cell types with numerous epigenetic states in...
Frenette, Catherine T Morelli, Giuseppe Shiffman, Mitchell L Frederick, R Todd Rubin, Raymond A Fallon, Michael B Cheng, Jason T Cave, Matt Khaderi, Saira A Massoud, Omar
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Published in
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Caspase-mediated apoptosis and inflammation contribute to progression of liver disease. Emricasan is a pan-caspase inhibitor that reduced serum markers of apoptosis and liver inflammation in patients with hepatitis C and non-alcoholic steatohepatitis (NASH). We performed a multicenter study of 86 patients with cirrhosis (Child-Pugh class A or B; me...
Swarup, Vivek Hinz, Flora I Rexach, Jessica E Noguchi, Ken-Ichi Toyoshiba, Hiroyoshi Oda, Akira Hirai, Keisuke Sarkar, Arjun Seyfried, Nicholas T Cheng, Chialin
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Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms in frontotemporal dementia. We identify two gene coexpression modules that are preserved in mice harboring mutations in MAPT, GRN and other ...
Farjadian, Fatemeh Rezaeifard, Somayeh Naeimi, Mahsa Ghasemi, Sahar Mohammadi-Samani, Soliman Welland, Mark Tayebi, Lobat
Zheng, Jing Chen, Juan Zou, Xiaohan Zhao, Fang Guo, Mengqi Wang, Hongbo Zhang, Tian Zhang, Chunlei Feng, Wei Pessah, Isaac N
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Saikosaponins (SSs) are a class of naturally occurring oleanane-type triterpenoid saponins found in Radix bupleuri that has been widely used in traditional Chinese medicine. As the main active principals of Radix bupleuri, SSs have been shown to suppress mouse motor activity, impair learning and memory, and decrease hippocampal neurogenesis. In the...
Abedpour, Neda Salehnia, Mojdeh Ghorbanmehr, Nassim
Published in
Cell journal
The aim of the present study was to examine whether lysophosphatidic acid (LPA) could decrease cell death and improve in vitro culture (IVC) conditions in cultured vitrified mouse ovarian tissue. In this experimental study, we collected and randomly divided 7-day-old mouse ovarian tissues into vitrified and non-vitrified groups. The ovaries were cu...
Faiz, A Heijink, IH Vermeulen, CJ Guryev, V van den Berge, M Nawijn, MC Pouwels, SD
© 2018, The Author(s). Cigarette smoking is a major risk factor for the inflammatory disease, chronic obstructive pulmonary disease (COPD). The mechanism by which cigarette smoke (CS) induces chronic lung inflammation is still largely unknown. We hypothesize that immunogenic airway epithelial cell death is involved in the initiation of the inflamma...
Husson, Zoé Smith, Ewan St John
