Wang, Hongzhou Zhang, Shunwen Zhao, Haijun Qin, Huiyuan Zhang, Jie Dong, Jiangtao Zhang, Hui Liu, Xiaoling Zhao, Zhengyong Zhao, Yanheng
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Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis. Pyroptosis, or cell death associated with sepsis, is mediated by caspase-1 activation. This study aimed to investigate the role of CO on the expression of proteins associated with intestinal mucosal pyroptosis in a rat model of sepsi...
lafont, elodie
Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from prolife...
Bolus, Stephen Akhunov, Eduard Coaker, Gitta Dubcovsky, Jorge
Nucleotide-binding leucine-rich repeat receptors (NLRs) are the most abundant type of immune receptors in plants and can trigger a rapid cell-death (hypersensitive) response upon sensing pathogens. We previously cloned the wheat NLR Sr35, which encodes a coiled-coil (CC) NLR that confers resistance to the virulent wheat stem rust race Ug99. Here, w...
Hwang, Shinae Kim, Jong-Keun
Published in
Chonnam Medical Journal
We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours induced neuronal death in a concentration-dependent manner. To delineate the mechanisms of fluoxetine-induced neuronal death, we investig...
Wong, Jerry Garcia-Carbonell, Ricard Zelic, Matija Ho, Samuel B Boland, Brigid S Yao, Shih-Jing Desai, Shalin A Das, Soumita Planell, Núria Harris, Philip A
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BACKGROUND AND AIMS:Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. Here, we investigated how chronic nuclear factor (NF)- κB activation, which occurs in hum...
Rogers, Corey Alnemri, Emad S.
Published in
The Yale Journal of Biology and Medicine
Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism. Although the molecular pathways leading to activation of the apoptotic program have been extensively studied and characterized starting ...
Ikonomov, Ognian C Sbrissa, Diego Shisheva, Assia
Published in
Toxicology and applied pharmacology
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in culture yet trigger non-apoptotic death through exces...
Puñal, Vanessa M Paisley, Caitlin E Brecha, Federica S Lee, Monica A Perelli, Robin M Wang, Jingjing O'Koren, Emily G Ackley, Caroline R Saban, Daniel R Reese, Benjamin E
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Naturally occurring cell death is a fundamental developmental mechanism for regulating cell numbers and sculpting developing organs. This is particularly true in the nervous system, where large numbers of neurons and oligodendrocytes are eliminated via apoptosis during normal development. Given the profound impact of death upon these two major cell...
Santra, Mantu Dill, Ken A de Graff, Adam MR
What molecular processes drive cell aging and death? Here, we model how proteostasis-i.e., the folding, chaperoning, and maintenance of protein function-collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distracting the chaperones from folding the healthy protei...
Horsefield, Shane Burdett, Hayden Zhang, Xiaoxiao Manik, Mohammad K Shi, Yun Chen, Jian Qi, Tiancong Gilley, Jonathan Lai, Jhih-Siang Rank, Maxwell X
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SARM1(sterile-α andTIR motif containing protein 1)is responsible forNAD+depletion duringWalleriandegenerationassociated with neuropathies. Plant NLR (nucleotide-binding leucine-rich repeat) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related ...
