Zi, Yang Ma, Chi He, Shan Yang, Huan Zhang, Min Gao, Feng Liu, Yingchun
Published in
Animal bioscience
This study investigated the effects of intrauterine growth restriction (IUGR) during late pregnancy on the cell growth, proliferation, and differentiation in ovine fetal thymuses. Eighteen time-mated Mongolian ewes with singleton fetuses were allocated to three groups at d 90 of pregnancy: restricted group 1 (RG1, 0.18 MJ ME/body weight [BW]0.75/d,...
Huang, Yuqing Chen, Shouguo Lei, Yuhe Chung, Chiwing Chan, Meiching Chen, Lei Zhong, Yinqin Zhang, Enxin Chen, Jiaxu Deng, Lijuan
...
Published in
Recent patents on anti-cancer drug discovery
Cervical cancer is the fourth most prevalent gynecological cancer worldwide, which threatens women's health and causes cancer-related mortality. In the search for effective anticervical cancer drugs, we discovered that β-estradiol (E2), a potent drug for estrogen deficiency syndrome treatment, displays the most potent cytotoxicity against HeLa cell...
Mun, Jeong-Geon Han, Yo-Han Jeon, Hee-Dong Yoon, Dae Hwan Lee, Yeong Gyeong Hong, Seung-Heon Kee, Ji-Ye
Published in
The American journal of Chinese medicine
Colorectal cancer (CRC) is the second most common cause of cancer death in the world, and metastatic CRC is a major cause of cancer death. Gallotannin (GT), a polyphenolic compound, has shown various biological effects such as anti-oxidant, anti-inflammatory, antimicrobial, and antitumor effects. However, the effects of GT on metastatic CRC cells a...
Chen, Yun-Fang Lee, An-Sheng Chen, Wei-Yu Lin, Chia-Hsin Kuo, Chao-Lin Chung, Jing-Gung
Published in
The American journal of Chinese medicine
Bauhinia championii (Benth.) is one of the commonly used herbs in Taiwan. The stem of this plant has been used to treat epigastria pain and rheumatoid arthritis. However, the antitumor activities of this herb have never been reported. This study aims to investigate the mechanism of anticancer activity of the extracts from B. championii (BC). BC was...
Jang, Soojin Ryu, Se Min Lee, Jooyeon Lee, Hanbyeol Hong, Seok-Ho Ha, Kwon-Soo Park, Won Sun Han, Eun-Taek Yang, Se-Ran
Published in
Tuberculosis and Respiratory Diseases
Background Idiopathic pulmonary fibrosis involves irreversible alveolar destruction. Although alveolar epithelial type II cells are key functional participants within the lung parenchyma, how epithelial cells are affected upon bleomycin (BLM) exposure remains unknown. In this study, we determined whether BLM could induce cell cycle arrest via regul...
Ito, Takao Igaki, Tatsushi
Published in
Inflammation and Regeneration
Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against carcinogenesis in mammals. In response to various stresses including oxidative stress, DNA damage, and oncogenic stress, suffered cells undergo ...
Zimmermann, Maike Arachchige-Don, Aruni P S Donaldson, Michaela S Patriarchi, Tommaso Horne, Mary C
Published in
Cell cycle (Georgetown, Tex.)
Definition of cell cycle control proteins that modify tumor cell resistance to estrogen (E2) signaling antagonists could inform clinical choice for estrogen receptor positive (ER+) breast cancer (BC) therapy. Cyclin G2 (CycG2) is upregulated during cell cycle arrest responses to cellular stresses and growth inhibitory signals and its gene, CCNG2, i...
Zhao, Shouye Liu, Peng Wen, Xinyuan Jin, Song
Published in
Molecular Biology Reports
Lee, Pearl Cheung, Eric C Vousden, Karen H
Published in
Cancer & Metabolism
Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc
Published in
Cancer letters
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by modifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-cancer therapies. In this study, we identif...
