Farhat, Sarah Le, Phuong Kayal, Ehsan Noel, Benjamin Bigeard, Estelle Corre, Erwan Maumus, Florian Florent, Isabelle Alberti, Adriana Aury, Jean-Marc
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Published in
BMC Biology
BackgroundDinoflagellates are aquatic protists particularly widespread in the oceans worldwide. Some are responsible for toxic blooms while others live in symbiotic relationships, either as mutualistic symbionts in corals or as parasites infecting other protists and animals. Dinoflagellates harbor atypically large genomes (~ 3 to 250 Gb), with gene...
Kabelac, Zachary Tarolli, Christopher G. Snyder, Christopher Feldman, Blake Glidden, Alistair Hsu, Chen-Yu Hristov, Rumen Dorsey, E. Ray Katabi, Dina
Published in
Digital Biomarkers
We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the abi...
Shimomura, Iwao Watanabe, Naoaki Yamamoto, Tomofumi Kumazaki, Minami Tada, Yuji Tatsumi, Koichiro Ochiya, Takahiro Yamamoto, Yusuke
Published in
JCI insight
Lung cancer with oncogenic KRAS makes up a significant proportion of lung cancers and is accompanied by a poor prognosis. Recent advances in understanding the molecular pathogenesis of lung cancer with oncogenic KRAS have enabled the development of drugs, yet mutated KRAS remains undruggable. We performed small-molecule library screening and identi...
Panzarino, Nicholas J.
Cancers that are deficient in BRCA1 or BRCA2 are thought to be hypersensitive to genotoxic agents because they cannot prevent or repair DNA double strand breaks, but observations in patients suggest this dogma may no longer agree with experiment. Here, we propose that single stranded DNA underlies the hypersensitivity of BRCA deficient cancers, and...
De Smet, Maarten Aj; Lissoni, Alessio; Nezlobinsky, Timur; Wang, Nan; Dries, Eef; 72461; Pérez-Hernández, Marta; Lin, Xianming; Amoni, Matthew; Vervliet, Tim; 73904; Witschas, Katja;
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Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting Cx43 hemichannel opening with Gap19 has antiarrhyt...
Tsumagari, Kazuya Chang, Chih-Hsiang Ishihama, Yasushi
膜タンパク質が「はさみ分子」によって切断される部位を大規模に解明 --細胞間コミュニケーションの制御機構解明に向けて--. 京都大学プレスリリース. 2021-03-30. / Ectodomain shedding is a proteolytic process that regulates the levels and functions of membrane proteins. Dysregulated shedding is linked to severe diseases, including cancer and Alzheimer's disease. However, the exact cleavage sites of shedding substrates rem...
Lee, Kyounghwan Craig, Roger W. Sadayappan, Sakthivel
Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N')-region (C0-C2 domains, 358 amino acids). On the other hand, dephosphorylation of cMyBP-C during myocardial injury results in cleavage of the 271 amino acid C0-C1f reg...
Mougkogianni, Maria Kalogeropoulou, Argyro Giakoumakis, Nickolaos Nikiforos Lygerou, Zoi Taraviras, Stavros
Published in
STAR protocols
The recruitment of the minichromosome maintenance complex (MCM) on DNA replication origins is a critical process for faithful genome duplication termed licensing. Aberrant licensing has been associated with cancer and, recently, with neurodevelopmental diseases. Investigating MCM loading in complicated tissues, such as brain, remains challenging. H...
Van Houcke, Jolien; 104544; Marien, Valerie; Zandecki, Caroline; 134811; Seuntjens, Eve; 10929; Ayana, Rajagopal; 129074; Arckens, Lutgarde; 3832;
Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fully restore brain function, which would imply neur...
Preman, Pranav; 119652; Alfonso-Triguero, Maria; Alberdi, Elena; Verkhratsky, Alexei; Arranz, Amaia M;
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer's among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. T...
